Results 221 to 230 of about 102,224 (277)

Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma

Science Translational Medicine, 2016
Huan Liu, Zhiqiang Liu, Pei Lin
exaly   +2 more sources

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Thymidine phosphorylase expression in endometrial carcinomas

Clinical & Experimental Metastasis, 1999
Thymidine phosphorylase (TP) is a potent angiogenic molecule shown to induce endothelial cell migration and proliferation. We investigated the expression of TP in a series of 156 endometrial carcinomas, using immunohistochemical methods. Histopathological parameters of known prognostic significance and the molecular factors of p53, bcl-2 and ...
E, Sivridis, A, Giatromanolaki, M I, Koukourakis, R, Bicknell, A L, Harris, K C, Gatter   +5 more
openaire   +2 more sources

Thymidine Phosphorylase Expression in Gallbladder Adenocarcinomas

International Journal of Surgical Pathology, 2002
The expression of thymidine phosphorylase (TP), a potent chemotactic factor for enothelial cells, was studied in 60 adenocarcinomas of the gallbladder, by use of imunohistochemical techniques. Results on patterns of TP expression were correlated with angiogenesis (anti-CD31), histopathological variables, and patient survival.
Alexandra, Giatromanolaki, Efthimios, Sivridis, Constantinos, Simopoulos, Alexandros, Polychronidis, Kevin C, Gatter, Adrian L, Harris, Michael I, Koukourakis   +6 more
openaire   +2 more sources

Radiosensitization by Thymidine Phosphorylase Inhibitor in Thymidine Phosphorylase Negative and Overexpressing Bladder Cancer Cell Lines

Nucleosides, Nucleotides and Nucleic Acids, 2014
TAS-102 (trifluorothymidine [TFT] and thymidine phosphorylase inhibitor [TPI] in a molar ratio of 1:0.5) has activity in 5-fluorouracil resistant colon cancer. TPI is added to increase TFT's bioavailability. TFT has a dual mechanism of action by inhibiting thymidylate synthase and by its incorporation into DNA.
El-Naggar, M., Ebbing, E., Bijnsdorp, I.V., van den Berg, J., Peters, G.J.   +4 more
openaire   +4 more sources

Thymidine phosphorylase inhibits apoptosis induced by cisplatin

Biochemical and Biophysical Research Communications, 2003
An angiogenic factor, platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP), stimulates the chemotaxis of endothelial cells and confers resistance to apoptosis induced by hypoxia. 2-Deoxy-D-ribose, a degradation product of thymidine generated by TP, partially prevents hypoxia-induced apoptosis.
Ryuji, Ikeda, Tatsuhiko, Furukawa, Ryoichi, Mitsuo, Tomohiro, Noguchi, Masaki, Kitazono, Hiroshi, Okumura, Tomoyuki, Sumizawa, Misako, Haraguchi, Xiao-Fang, Che, Hiroshi, Uchimiya, Yuich, Nakajima, Xiao Qin, Ren, Shigeru, Oiso, Ituro, Inoue, Katsushi, Yamada, Shin-ichi, Akiyama   +15 more
openaire   +2 more sources

Purification of thymidine phosphorylase from human amniochorion

Biochimica et Biophysica Acta (BBA) - Enzymology, 1978
Thymidine phosphorylase (thymidine : orthophosphate deoxyribosyltransferase, EC 2.4.2.4) has been purified 1500-fold from extracts of human amniochorion. The purified enzyme catalyzes the phosphorolysis of deoxythymidine and to a lesser extent deoxyuridine but not deoxycytidine nor uridine.
J, Kubilus, L D, Lee, H P, Baden
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Substrate specificity of Escherichia coli thymidine phosphorylase

Biochemistry (Moscow), 2007
Substrate specificity of Escherichia coli thymidine phosphorylase to thymidine derivatives modified at 5' -, 3' -, and 2' ,3' - positions of the sugar moiety was studied. Equilibrium and kinetic constants (K(m), K(I), k(cat)) of the phosphorolysis reaction have been determined for 20 thymidine analogs.
N G, Panova, C S, Alexeev, A S, Kuzmichov, E V, Shcheveleva, S A, Gavryushov, K M, Polyakov, A M, Kritzyn, S N, Mikhailov, R S, Esipov, A I, Miroshnikov   +9 more
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Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo

International Journal of Oncology, 2003
Metastasis or progression of ovarian cancer cells is known to be due to the action of various angiogenic factors. We determined the expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) and vascular endothelial growth factor (VEGF) in cell lines established from 3 serous adenocarcinomas, 3 clear cell ...
Shizuka, Tsukagoshi, Yasushi, Saga, Norihiko, Suzuki, Akio, Fujioka, Fumio, Nakagawa, Masakazu, Fukushima, Mitsuaki, Suzuki   +6 more
openaire   +2 more sources

Benzothiazole-based 1,3,4-thiadiazole hybrids derivatives as effective inhibitors of urease and thymidine phosphorylase: Synthesis, in vitro and in silico approaches

Journal of Molecular Structure, 2023
Yousaf Khan, W. Rehman, R. Hussain, Shoaib Khan, Aneela Maalik   +4 more
semanticscholar   +1 more source

New Thiazole-Bearing Oxadiazole Derivatives: Synthesis, Thymidine Phosphorylase Inhibitory Potential, and Molecular Docking Study

Russian journal of organic chemistry, 2021
H. Ullah, F. Khan, M. Taha, F. Rahim, M. Sarfraz, A. Aziz, S. Ullah, M. U. Khan, M. Ullah   +8 more
semanticscholar   +1 more source