Results 231 to 240 of about 102,224 (277)

Synthesis, in vitro thymidine phosphorylase activity and molecular docking study of thiadiazole bearing isatin analogs

Chemické zvesti, 2021
H. Ullah, Anjum Liaqat, Q. Khan, M. Taha, Fahad Khan, F. Rahim, I. Uddin, Zia Ur Rehman   +7 more
semanticscholar   +1 more source

Localization of thymidine phosphorylase in breast cancer tissue

Medical Molecular Morphology, 2005
Thymidine phosphorylase levels are higher in some human cancer tissues than in adjacent normal tissue. However, the ultrastructural localization of thymidine phosphorylase in cancer tissue has been demonstrated only in advanced gastric and colorectal cancer.
Michiya, Kobayashi, Takeki, Sugimoto, Takehiro, Okabayashi, Ken, Okamoto, Tsutomu, Namikawa, Naoshige, Tochika, Toshiaki, Moriki, Keijiro, Araki   +7 more
openaire   +2 more sources

Design, synthesis, modelling studies and biological evaluation of 1,3,4-oxadiazole derivatives as potent anticancer agents targeting thymidine phosphorylase enzyme.

Bioorganic chemistry (Print), 2021
S. Bajaj, Maushmi S. Kumar, Hussain Tinwala, Mayur Yc   +3 more
semanticscholar   +1 more source

Thymidine phosphorylase mutations cause instability of mitochondrial DNA

Gene, 2005
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder characterized by ptosis and progressive external ophthalmoplegia, peripheral neuropathy, severe gastrointestinal dysmotility, cachexia and leukoencephalopathy. Muscle biopsies of MNGIE patients have revealed morphologically abnormal mitochondria and defects
Hirano, M., Lagier Tourenne, C., VALENTINO, MARIA LUCIA, Martí, R., Nishigaki, Y.   +4 more
openaire   +2 more sources

Thymidine phosphorylase in human esophageal squamous cell carcinoma

Cancer, 1999
Experimental evidence has shown that thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and has angiogenic activity. The enzymatic activity of dThdPase was needed for the angiogenesis by the enzyme.
Y, Takebayashi, S, Natsugoe, M, Baba, S, Akiba, T, Fukumoto, K, Miyadera, Y, Yamada, S, Takao, S, Akiyama, T, Aikou   +9 more
openaire   +2 more sources

Thymidine phosphorylase and breast carcinoma.

Anticancer research, 2002
Thymidine phosphorylase (TP), also known as platelet-derived endothelial-cell growth factor (PD-ECGF), is an enzyme that catalyzes the reversible dephosphorylation of thymidine, deoxyguridine and their analogs. TP also has angiogenic properties, although the precise mechanism by which it promotes angiogenesis is not known.
Qifeng, Yang, Goro, Yoshimura, Ichiro, Mori, Takeo, Sakurai, Kennichi, Kakudo   +4 more
openaire   +1 more source

[Thymidine phosphorylase and angiogenesis].

Gan to kagaku ryoho. Cancer & chemotherapy, 2000
Thymidine phosphorylase (TP) is identical to platelet-derived endothelial cell growth factor (PD-ECGF). TP has an angiogenic activity and confers resistance to hypoxia-induced apoptosis on cells. TP expression is correlated with microvessel count, invasion and poor prognosis in many solid tumors.
openaire   +1 more source

[Expression of thymidine phosphorylase in cancer].

Zhonghua zhong liu za zhi [Chinese journal of oncology], 2005
To study the thymidine phosphorylase (TP) expression in different types of cancer and its correlation with tumor microvessel density (MVD).The expression of TP and MVD was detected by immunohistochemistry method. In a series of 251 cancer patients there were 48 patients with gastric cancer, 53 with colorectal cancer, 47 with breast cancer, 56 with ...
Li-na, Jiang, Shi-ying, Yu, Hui-hua, Xiong, Meng-xian, Zhang   +3 more
openaire   +1 more source

Phosphorylase-catalyzed bottom-up synthesis of short-chain soluble cello-oligosaccharides and property-tunable cellulosic materials

Biotechnology Advances, 2021
Bernd Nidetzky, Chao Zhong
exaly  

Facile 3-chloro-1H-indazole based 1,3,4-thiadiazole derivatives as novel thymidine phosphorylase and anti-diabetic inhibitors: Experimental, in-vitro and molecular modelling approaches.

Naunyn-Schmiedeberg's Archives of Pharmacology
Yousaf Khan, Aneela Maalik, W. Rehman, Hina Sarfraz, Rafaqat Hussain, Shoaib Khan, Marouan Kouki, Aisha Usman, Rubina Adnan   +8 more
semanticscholar   +1 more source