Results 151 to 160 of about 208,657 (313)

Precise delineation of radiation targets for thoracic tumors in the immunotherapy era: from immune mechanisms to clinical practice

Precision Radiation Oncology, EarlyView.
RT‐immunotherapy synergy for thoracic tumors relies on precise target delineation to protect immune components. IFI, reduced volumes, and optimized positioning minimize damage, while multimodal imaging, DL, PBT, and FLASH‐RT enhance control. These innovations shift RT to an immune‐centric model, improving lung and esophageal cancer outcomes.
Xiaoying Chen, Minxiao Yi, Yu Deng, Qian Shen   +3 more
wiley   +1 more source

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

Phytotherapy Research, EarlyView.
GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao, Da Ke, Jian Ni, Yuan Yuan, Zhang Nan, Xiujun Dai, Heng Zhou   +6 more
wiley   +1 more source

The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire. [PDF]

Aging Cell
Rowell J, Yanez DC, Ross S, Lau CI, Zhang E, Monfared A, Peña OA, Chain B, Crompton T.   +8 more
europepmc   +1 more source

Assessing the Health Impacts of Contaminants on Green Turtles (Chelonia mydas) Along the Southern Coast of Brazil

Environmental Toxicology, EarlyView.
ABSTRACT Chemical pollutants pose a significant threat to marine ecosystems. Among these contaminants are trace elements and polycyclic aromatic hydrocarbons (PAH). Green turtles can be employed to evaluate the oceans' health due to their coastal habitats and exposure to multiple threats.
Camila Roberta da Silva Ribeiro, Andressa Maria Rorato Nascimento de Matos, Eloiza Teles Caldart, Liana Rosa, Camila Domit, Guilherme dos Santos Lima, Ana Paula Frederico Rodrigues Loureiro Bracarense   +6 more
wiley   +1 more source

Comparative Phytochemical and Biological Evaluation of Four Thymus Species From Türkiye for Dermocosmetic Applications. [PDF]

Chem Biodivers
Özdemir Nath E, Campos PE, Le Cabec A, Gündoğan Gİ, Ergin D, Çetin A, Sönmez S, Destandau E.   +7 more
europepmc   +1 more source

Fetal aortic morphometry by echocardiography: reproducibility study using stringent criteria and standardized nomenclature

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To establish and assess the reproducibility of standardized echocardiographic nomenclature and the protocol for comprehensive evaluation of fetal aortic morphology. Methods This was a prospective cohort study of fetuses with a normal three‐vessel branching pattern of the aortic arch, evaluated from 18–40 weeks' gestation at a single ...
P. Vazirani, L. Nogué, A. Fernández, M. Pérez, M. Guilleumes, E. Cabello, A. Sepúlveda‐Martínez, M. C. Escobar‐Díaz, G. Bernardino, B. Bijnens, F. Crispi, O. Gómez   +11 more
wiley   +1 more source

Guidelines To Predict Binding Poses of Antibody–Integrin Complexes

ACS Omega, 2020
Beatriz Chaves, Geraldo R. Sartori, Disraeli C. A. Vasconcelos, Wilson Savino, Ernesto R. Caffarena, Vinícius Cotta-de-Almeida, João H. M. da Silva   +6 more
doaj   +1 more source

Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric heart recipients were associated with impairment of the immune system - a multicenter study from Sweden. [PDF]

JHLT Open
Ekman-Joelsson BM, Odermarsky M, Tran-Lundmark K, Sjöborg-Alpman M, Lannering K, Andersson B, Malmeström C, Wåhlander H, Mellgren K, Ekwall O.   +9 more
europepmc   +1 more source

Safety of and serological response to a new canine distemper‐parvovirus combination vaccine in domestic ferrets

Veterinary Record, EarlyView.
Abstract Background Pet ferrets are typically vaccinated against distemper using a canine multivalent vaccine despite the lack of relevant safety or efficacy data. Here, we investigate the safety of a novel live canine parvovirus type 2c (CPV‐2c) vaccine strain and the efficacy of the live Onderstepoort canine distemper virus (CDV) vaccine strain used ...
Jacqueline Pearce, Léon Peeters, Ellen Versmissen, David Sutton, Ian Tarpey   +4 more
wiley   +1 more source

The thymus gland is a target and maintainer of amyotrophic lateral sclerosis pathophysiology. [PDF]

Brain Behav Immun Health
Lemos JP, Stockholm D, Dinatale B, Chaves AS, Pezet S, Frias Carvalho V, Pérez AR, Mendes-da-Cruz DA, Savino W, Smeriglio P.   +9 more
europepmc   +1 more source