Results 1 to 10 of about 45,812 (254)
Interleukin-21 accelerates thymic recovery from glucocorticoïd-induced atrophy. [PDF]
PLoS ONE, 2013 Both physiological and psychological stress cause thymic atrophy via glucocorticoïd (GC)-dependent apoptosis of double-positive (DP) thymocytes. Given the pervasiveness of stress, GC-induced thymic atrophy is arguably the most common type of acquired ...
Moutih Rafei +3 more
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A quantitative study of the mechanisms behind thymic atrophy in Gαi2-deficient mice during colitis development. [PDF]
PLoS ONE, 2012 Mice deficient for the G protein subunit Gαi2 spontaneously develop colitis, a chronic inflammatory disease associated with dysregulated T cell responses.
Kristina Elgbratt +2 more
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Scientific Reports, 2023 Phenotypic markers that denote different developmental stages of thymocytes are important for understanding T cell development in the thymus. Here, we show that CD1b is a critical discriminator of thymocyte maturation stage in cynomolgus monkeys.
Sung Min Choi +4 more
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Critical role of WNK1 in MYC-dependent early mouse thymocyte development
eLife, 2020 WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse ...
Robert Köchl +9 more
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Frontiers in Immunology, 2020 Thymocyte differentiation is dependent on the availability and transport of metabolites in the thymus niche. As expression of metabolite transporters is a rate-limiting step in nutrient utilization, cell surface transporter levels generally reflect the ...
Alice Machado +15 more
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Selective reduction of post-selection CD8 thymocyte proliferation in IL-15Rα deficient mice. [PDF]
PLoS ONE, 2012 Peripheral CD8(+) T cells are defective in both IL-15 and IL-15Rα knock-out (KO) mice; however, whether IL-15/IL-15Rα deficiency has a similar effect on CD8 single-positive (SP) thymocytes remains unclear.
Kai-Ping N Chow +7 more
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Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages
eLife, 2022 Interactions of developing T cells with Aire+ medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEChi) are critical for the induction of central tolerance in the thymus.
Noella Lopes +7 more
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Development of double-positive thymocytes at single-cell resolution
Genome Medicine, 2021 Background T cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our understanding of the development of thymocytes at the genetic and epigenetic levels.
Young Li +9 more
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Effect of extracts from microalgae on cytokine levels in female C57Bl6 mice
Медицинская иммунология, 2023 Microalgae from the freshwater basins and seas are a valuable source of broad-spectrum biologically active substances that can affect the cells of immune system and their functional state.
A. P. Lykov +3 more
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Cells, 2022 The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4+CD25+Foxp3 ...
Carlotta Barahona de Brito +1 more
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