Results 11 to 20 of about 48,213 (250)
Cell Reports, 2018 Summary: T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly distinct
Anne Gegonne +8 more
doaj +2 more sources
Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion. [PDF]
Adv Sci (Weinh)Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Ping J, Wang W, Xu J, Yang M, Wu N.
europepmc +2 more sources
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development [PDF]
, 2010 PhDThe pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes through the “β-selection ...
Mahtani-Patching, Juliet L
core +3 more sources
Development of double-positive thymocytes at single-cell resolution
Genome Medicine, 2021 Background T cells generated from thymopoiesis are essential for the immune system, and recent single-cell studies have contributed to our understanding of the development of thymocytes at the genetic and epigenetic levels.
Young Li +9 more
doaj +1 more source
Effect of extracts from microalgae on cytokine levels in female C57Bl6 mice
Медицинская иммунология, 2023 Microalgae from the freshwater basins and seas are a valuable source of broad-spectrum biologically active substances that can affect the cells of immune system and their functional state.
A. P. Lykov +3 more
doaj +1 more source
The radiosensitivity of rat thymocytes [PDF]
Biochemical Journal, 1986 gamma-Irradiation in vitro apparently blocked a plasma-membrane associated, superoxide-producing, NADPH oxidase in rat thymocytes. Differential centrifugation of the mixed thymocytes indicated the smaller lymphocytes (approx. 6 microns diameter) to be the radiosensitive population.
M G, Ord, L A, Stocken
openaire +2 more sources
Natriuretic peptide receptors on rat thymocytes: Inhibition of proliferation by atrial natriuretic peptide. [PDF]
, 1996 Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested.
Schmidt, Karin-Nicole +3 more
core +2 more sources
Cells, 2022 The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4+CD25+Foxp3 ...
Carlotta Barahona de Brito +1 more
doaj +1 more source
Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. [PDF]
, 2007 Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage.
Outram, Susan V +9 more
core +1 more source