Results 11 to 20 of about 45,812 (254)

Thymocytes can tolerize thymocytes by clonal deletion in vitro [PDF]

International Immunology, 1992
Clonal deletion of thymocytes bearing TCR for self antigens is one major mechanism of T cell tolerance induction. Peptide antigen-induced deletion of thymocytes from αβ TCR transgenic mice has been studied using single cell suspension cultures. The results show that antigen-presenting immature CD4+CD8+ thymocytes can tolerize antigen-reactive immature ...
Pircher, Hanspeter, Müller, Klaus-Peter, Kyewski, Bruno A., Hengartner, Hans   +3 more
openaire   +7 more sources

Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development [PDF]

, 2010
PhDThe pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes through the “β-selection ...
Mahtani-Patching, Juliet L
core   +4 more sources

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression. [PDF]

Cancer Sci
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Tibarewal P, Spinelli L, Kriplani N, Wise H, Poncet N, Marzano G, Anderson KE, Grzes KM, Varyova Z, Adil M, Downes CP, Hawkins PT, Stephens LR, Storey KG, Cantrell DA, Vanhaesebroeck B, Leslie NR.   +16 more
europepmc   +2 more sources

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Immature thymocyte antigen-1: a novel thymocyte marker discriminating pre- and post-selected thymocytes [PDF]

International Immunology, 1998
Previously, we described a mAb (1-23) reacting with a novel cell surface antigen expressed on thymocytes at late CD4-CD8- [(double negative (DN)] to early CD4+CD8+ [(double positive (DP)] differentiation stage. Since the expression of this molecule was restricted to immature thymocytes, we designated it as immature thymocyte antigen-1 (IMT-1).
H, Kishi, J J, Tong, T, Nagata, A, Muraguchi   +3 more
openaire   +2 more sources

Natriuretic peptide receptors on rat thymocytes: Inhibition of proliferation by atrial natriuretic peptide. [PDF]

, 1996
Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested.
Schmidt, Karin-Nicole, Vollmar, Angelika M., Schulz, Rüdiger, A. M. Vollmar   +3 more
core   +2 more sources

Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. [PDF]

, 2007
Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage.
Outram, Susan V, Dessens, Johannes T, Nicola J. Rowbotham, Rowbotham, Nicola J, Tessa Crompton, Hager-Theodorides, Ariadne L, Ariadne L. Hager‐Theodorides, Susan V. Outram, Crompton, Tessa, Johannes T. Dessens   +9 more
core   +1 more source

A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway. [PDF]

PLoS ONE, 2010
A complete understanding of negative selection has been elusive due to the rapid apoptosis and clearance of thymocytes in vivo. We report a TCR transgenic model in which expression of the TCR during differentiation occurs only after V(D)J-like ...
Damian Kovalovsky, Mark Pezzano, Benjamin D Ortiz, Derek B Sant'Angelo   +3 more
doaj   +1 more source

The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation

Frontiers in Immunology, 2021
Invariant NKT (iNKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular mechanism that drives the lineage trifurcation of immature iNKT cells into the NKT1, NKT2, and NKT17
Hee Yeun Won, Hye Kyung Kim, Assiatu Crossman, Parirokh Awasthi, Ronald E. Gress, Jung-Hyun Park   +5 more
doaj   +1 more source

Analysis of thymocyte MHC specificity with thymocyte hybridomas. [PDF]

The Journal of experimental medicine, 1984
Medullary, peanut agglutinin-negative (PNA-), thymocytes were activated in vitro with either exogenous interleukin 1 (IL-1) or accessory cells. T cell blasts from these cultures were subsequently fused to BW5147 to generate thymocyte hybridomas. Fusion frequencies similar to those obtained with peripheral T lymphocytes were observed.
E T, Yeh, B, Benacerraf, K L, Rock
openaire   +2 more sources