Results 41 to 50 of about 67,295 (252)

Metabolic regulation of T cell development

Frontiers in Immunology, 2022
T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and posttranslational control of the intrathymic journey of T-cell precursors ...
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao   +7 more
doaj   +1 more source

Neurotransmitters Modulate Intrathymic T-cell Development

Frontiers in Cell and Developmental Biology, 2021
The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues.
Carolina Francelin, Carolina Francelin, Carolina Francelin, Luciana Peixoto Veneziani, Luciana Peixoto Veneziani, Luciana Peixoto Veneziani, Alessandro dos Santos Farias, Alessandro dos Santos Farias, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Wilson Savino, Wilson Savino, Wilson Savino   +14 more
doaj   +1 more source

Aldehydes participation in oxidative stress in rat thymocytes in vitro [PDF]

The Ukrainian Biochemical Journal, 2014
A variety of lipid radicals are formed under oxidative stress development. The further oxidation of these radicals leads to formation of numerous aldehydes.
K. О. Tokarchuk, О. V. Zaitseva
doaj   +1 more source

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

eLife, 2021
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen   +13 more
doaj   +1 more source

Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells

Cells, 2022
The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the
Xie Xu, Kai He, Robert D. Hoffman, Yuyuan Ying, Nana Tao, Wenqin Guo, Jiaman Shen, Xi Liu, Meiya Li, Meiqiu Yan, Guiyuan Lv, Jianli Gao   +11 more
doaj   +1 more source

Perp Deficiency Induces Defective Negative Selection and Autoimmune Arthritis in Aged Mice [PDF]

Aging Cell
Perp deficiency promotes age‐related autoimmunity. ABSTRACT Thymic negative selection is characterized by the apoptosis of autoreactive thymocytes and plays a critical role in maintaining self‐tolerance. Numerous apoptosis‐related genes influence cell fate during T‐cell development.
Zhou Y, Li J, Leng X, Shi J, Zhang G, Chen S, Liu D, Deng Q, He Y, Shi G, Xu Y, Liu Y, Wang Y.   +12 more
europepmc   +2 more sources

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [PDF]

, 2018
Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear.
A Hutloff, AK Stanic, B San Luis, BB Au-Yeung, BB Au-Yeung, CQ Chu, D Davidson, DG Pellicci, DG Pellicci, DG Wei, DI Godfrey, EJ Wherry, F Scheuplein, F Scheuplein, FW McNab, G Anderson, G Fu, G Kollias, G Seumois, H Georgiev, H Watarai, HS Azzam, I Engel, I Engel, J Henao-Mejia, J Novak, J Zikherman, JL Matsuda, JL Matsuda, JM Mason, K Benlagha, K Hirota, K Oleinika, K Yamamoto, L Brossay, L Linsen, LH Mason, LM D'Cruz, M Cruz Tleugabulova, M Gaya, M Guma, M Hashimoto, M Kronenberg, M Zhu, MA Weinreich, MB Drennan, MC Leite-De-Moraes, MC Leite-De-Moraes, MI Zimmer, MP Seiler, N Bottini, N Sakaguchi, NA Nagarajan, R Genolet, RJ Martinez, S Akbulut, S Jung, S Picelli, S Sidobre, SE Levin, TN Newman, V Cerundolo, V Sivakumar, WY Lee, X Li, YJ Lee, YL Chiu   +66 more
core   +4 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled

Frontiers in Immunology, 2023
Marine fish larvae often experience high mortality unrelated to predation during early life stages, and farmed ballan wrasse (Labrus bergylta) is no exception.
Angela Etayo, Angela Etayo, Kai K. Lie, Reidun M. Bjelland, Ivar Hordvik, Aina-Cathrine Øvergård, Øystein Sæle   +6 more
doaj   +1 more source

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source