Results 41 to 50 of about 45,812 (254)

RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation [PDF]

European Journal of Immunology, 2002
Thymocyte maturation is controlled by successive developmental checkpoints connected to the acquisition of a functional T cell receptor (TCR). During thymocyte selection, engagement of the TCR regulates the fine balance between death and survival signals.
Sandrine, Guerin, Marie-Laurence, Baron, René, Valero, Magali, Herrant, Patrick, Auberger, Philippe, Naquet   +5 more
openaire   +2 more sources

Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells

Cells, 2022
The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the
Xie Xu, Kai He, Robert D. Hoffman, Yuyuan Ying, Nana Tao, Wenqin Guo, Jiaman Shen, Xi Liu, Meiya Li, Meiqiu Yan, Guiyuan Lv, Jianli Gao   +11 more
doaj   +1 more source

The effects of intracerebroventricularly applied ghrelin on thymocytes and thymic architecture in rats of different ages [PDF]

Archives of Biological Sciences, 2020
Ghrelin positively influences the total number of thymocytes and size of the thymus in 14-, 20- and 24-month-old rats. We examined the effect of centrally-applied ghrelin on thymus weight and structure in Wistar rats of different ages. The study included
Todorović Jovana S., Terzić-Šupić Zorica J., Mazić Sanja D., Suzić-Lazić Jelena M., Žikić Dejan D., Nešić Dejan M.   +5 more
doaj   +1 more source

The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire. [PDF]

Aging Cell
Ageing profoundly alters the thymic microenvironment, but its impact on T‐cell receptor (TCR) repertoire selection remains unclear. By sequencing TCRαβ repertoires from young and aged thymus, hydrocortisone‐depleted thymus and RAG1‐deficient thymus transplantation models, we show that the aged thymic microenvironment drives qualitative changes in TCR ...
Rowell J, Yanez DC, Ross S, Lau CI, Zhang E, Monfared A, Peña OA, Chain B, Crompton T.   +8 more
europepmc   +2 more sources

How many thymocytes audition for selection? [PDF]

, 1997
T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting with major histocompatibility complex (MHC) ligands to initiate positive and negative selection.
Bommhardt, U, Zamoyska, R, Fisher, AG, Ursula Bommhardt, Matthias Merkenschlager, Rose Zamoyska, Graf, D, Lovatt, M, Amanda G. Fisher, Merkenschlager, M, Daniel Graf, Matthew Lovatt   +11 more
core   +1 more source

Defects in Thymocyte Differentiation and Thymocyte‐ Stromal Interactions in the Trisomy 16 Mouse [PDF]

Journal of Immunology Research, 1992
We have examined fetal thymic development in the trisomy 16 (Ts16) mouse, which is considered to be a model for human trisomy 21, or Down Syndrome. The Ts16 thymus contains 10 to 20% of the number of lymphocytes found in a normal thymus at a comparable stage.
Ewart, Janet L., Auerbach, Robert
openaire   +2 more sources

The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled

Frontiers in Immunology, 2023
Marine fish larvae often experience high mortality unrelated to predation during early life stages, and farmed ballan wrasse (Labrus bergylta) is no exception.
Angela Etayo, Angela Etayo, Kai K. Lie, Reidun M. Bjelland, Ivar Hordvik, Aina-Cathrine Øvergård, Øystein Sæle   +6 more
doaj   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Impact of in vitro HIV infection on human thymic regulatory T cell differentiation

Frontiers in Microbiology, 2023
BackgroundThe differentiation and function of immunosuppressive regulatory T cells (Tregs) is dictated by the master transcription factor FoxP3. During HIV infection, there is an increase in Treg frequencies in the peripheral blood and lymphoid tissues ...
Sharada Swaminathan, Tatiana Scorza, Alexis Yero, Omar Farnos, Stephanie C. Burke Schinkel, Jonathan B. Angel, Jonathan B. Angel, Mohammad-Ali Jenabian   +7 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source