Results 41 to 50 of about 41,566 (244)
RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation [PDF]
European Journal of Immunology, 2002 Thymocyte maturation is controlled by successive developmental checkpoints connected to the acquisition of a functional T cell receptor (TCR). During thymocyte selection, engagement of the TCR regulates the fine balance between death and survival signals.
Sandrine, Guerin +5 more
openaire +2 more sources
IgM binds strongly to permeabilised non-apoptotic and apoptotic thymocytes. [PDF]
, 2015 Non-apoptotic and apoptotic mouse thymocytes, induced by overnight culture, were permeabilised with saponin prior to incubation with Balb/c plasma. Permeability was confirmed by PI staining and IgM binding was assessed by flow cytometry.
Jeremy Hughes (478330) +3 more
core +1 more source
HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression
Retrovirology, 2011 Background Thymic function is altered in HIV infection and characterized by dysregulation of the thymic epithelial network, reduced thymic output and ultimately an impaired naïve T-cell pool.
Young Charlene D, Angel Jonathan B
doaj +1 more source
Neurotransmitters Modulate Intrathymic T-cell Development
Frontiers in Cell and Developmental Biology, 2021 The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues.
Carolina Francelin +14 more
doaj +1 more source
How many thymocytes audition for selection? [PDF]
, 1997 T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting with major histocompatibility complex (MHC) ligands to initiate positive and negative selection.
Bommhardt, U +11 more
core +1 more source
Aldehydes participation in oxidative stress in rat thymocytes in vitro [PDF]
The Ukrainian Biochemical Journal, 2014 A variety of lipid radicals are formed under oxidative stress development. The further oxidation of these radicals leads to formation of numerous aldehydes.
K. О. Tokarchuk, О. V. Zaitseva
doaj +1 more source
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
eLife, 2021 Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu +13 more
doaj +1 more source
Casp9DN reduces ROS levels in primary thymocytes. [PDF]
, 2013 A) Representative histogram overlays of DHE stained viable thymocytes is shown. All cells were treated with or without Dex as indicated. Caspase activity was inhibited by either Casp9DN expression (red line, Casp9DN) or Q-VD-OPh treatment (blue line, WT ...
Sih-han Wang (351494) +3 more
core +1 more source
Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells
Cells, 2022 The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the
Xie Xu +11 more
doaj +1 more source
Transgene is not expressed in thymocytes. [PDF]
, 2017 (A) eGFP mRNA levels in thymocytes and thymic stroma of uninduced-K18 mice by RT-PCR. Thymocytes was released by gently applying pressure on thymus between two frosted glass slides, and then FACS-sorted for CD45+ cells.
Sophie Wang (1415950) +9 more
core +1 more source