Flow cytometry analysis of thymocytes.
, 2013 Thymocytes were characterized by their forward (FSC) and side scattering (SSC) properties(A). Thymocytes were gated by their CD3+ expression and SSC characteristics (B) in CD3 High(gate F), CD3 low (gate G), CD3 neg (gate H). Dot plots CD3 High DP and SP
Francesca Sabbatini (359364) +12 more
core +1 more source
Aldehydes participation in oxidative stress in rat thymocytes in vitro [PDF]
The Ukrainian Biochemical Journal, 2014 A variety of lipid radicals are formed under oxidative stress development. The further oxidation of these radicals leads to formation of numerous aldehydes.
K. О. Tokarchuk, О. V. Zaitseva
doaj +1 more source
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
eLife, 2021 Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu +13 more
doaj +1 more source
CD4 SP thymocytes, but not CD8 SP or DP thymocytes, store and mobilize pCD40L.
, 2012 A, Gating strategy for identifying CD8 SP, DP, and immature and mature CD4 SP thymocytes. B–E, Mobilization of pCD40L for immature (B) and mature (C) CD4 SP thymocytes, CD8 SP (D), and DP (E) thymocytes. Cd40lg−/− : CD40L-deficient mouse.
David B. Jacoby (182049) +7 more
core +1 more source
Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) alpha chains and promotes positive selection of class II-restricted TCR-transgenic thymocytes. [PDF]
, 1998 CD4 contributes to antigen recognition of T cells by binding to class II MHC molecules. There is heterogeneity in expression of CD4 coreceptor among CD4+CD8+ thymocytes.
Mueller, Christoph +4 more
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Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells
Cells, 2022 The thymus is the most sensitive organ under various pathophysiological conditions, such as aging, starvation, and infection. As a key stromal cell for T cell development, it is well-known that thymic epithelial cells (TECs) play an important role in the
Xie Xu +11 more
doaj +1 more source
Defects in Thymocyte Differentiation and Thymocyte‐ Stromal Interactions in the Trisomy 16 Mouse [PDF]
Journal of Immunology Research, 1992 We have examined fetal thymic development in the trisomy 16 (Ts16) mouse, which is considered to be a model for human trisomy 21, or Down Syndrome. The Ts16 thymus contains 10 to 20% of the number of lymphocytes found in a normal thymus at a comparable stage.
Ewart, Janet L., Auerbach, Robert
openaire +2 more sources
Increased CV of inducible CD69 expression in Dicer-deficient thymocytes.
, 2015 A) Activation of CD4+ CD8+ DP thymocytes (oval, top) results in CD69 expression (horizontal line defines CD69+ cells, middle) and definition of CD69hi cells (oval, bottom).
Amanda G. Fisher (78180) +11 more
core +1 more source
Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes
, 1998 The induction of apoptosis in thymocytes by the glucocorticoid dexamethasone was used as a model system to investigate whether there are changes in 20 S and 26 S proteasome activities during apoptosis.
Murray, Rachael +9 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga +3 more
wiley +1 more source