Results 61 to 70 of about 45,812 (254)
Vav regulates peptide-specific apoptosis in thymocytes. [PDF]
, 1998 The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells.
Mariathasan, S +19 more
core +1 more source
Mitochondrial uncoupling protein 1 expression in thymocytes [PDF]
, 2008 Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice.
Fallon, Padraic G. +3 more
core +2 more sources
Frontiers in Endocrinology, 2018 T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez +8 more
doaj +1 more source
Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation
Membranes, 2021 This work demonstrates the effects of a newly synthesized conjugate of the plant triterpenoid betulin and the penetrating cation F16 used for mitochondrial targeting. The resulting F16-betulin conjugate revealed a mitochondria-targeted effect, decreasing
Mikhail V. Dubinin +5 more
doaj +1 more source
American Journal of Hematology, EarlyView.ABSTRACT Posttransplant cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD) improves outcomes in recipients of HLA mismatched unrelated donor (MMUD) allogeneic hematopoietic cell transplantation (allo HCT). Outcomes of MMUD HCT using PTCy in patients requiring reduced intensity or non‐myeloablative conditioning (RIC/NMA) are not well ...
Brian C. Shaffer +38 more
wiley +1 more source
CD4 SP thymocytes, but not CD8 SP or DP thymocytes, store and mobilize pCD40L.
, 2012 A, Gating strategy for identifying CD8 SP, DP, and immature and mature CD4 SP thymocytes. B–E, Mobilization of pCD40L for immature (B) and mature (C) CD4 SP thymocytes, CD8 SP (D), and DP (E) thymocytes. Cd40lg−/− : CD40L-deficient mouse.
David B. Jacoby (182049) +7 more
core +1 more source
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
eLife, 2014 The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein ...
Brenda Y Han +8 more
doaj +1 more source
In Vivo and Ex Vivo Gene Transfer in Thymocytes and Thymocyte Precursors [PDF]
, 2009 The thymus provides a specialized environment allowing the differentiation of T lymphocytes from bone marrow-derived progenitor cells. We and others have demonstrated that gene transfer into distinct thymocyte populations can be obtained, both in vivo and ex vivo, using lentiviral vectors.
Oumeya, Adjali +8 more
openaire +2 more sources
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Flow cytometry analysis of thymocytes.
, 2013 Thymocytes were characterized by their forward (FSC) and side scattering (SSC) properties(A). Thymocytes were gated by their CD3+ expression and SSC characteristics (B) in CD3 High(gate F), CD3 low (gate G), CD3 neg (gate H). Dot plots CD3 High DP and SP
Francesca Sabbatini (359364) +12 more
core +1 more source