Results 61 to 70 of about 48,213 (250)
Advanced Science, EarlyView.HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu +12 more
wiley +1 more source
Frontiers in Endocrinology, 2018 T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez +8 more
doaj +1 more source
In Vivo and Ex Vivo Gene Transfer in Thymocytes and Thymocyte Precursors [PDF]
, 2009 The thymus provides a specialized environment allowing the differentiation of T lymphocytes from bone marrow-derived progenitor cells. We and others have demonstrated that gene transfer into distinct thymocyte populations can be obtained, both in vivo and ex vivo, using lentiviral vectors.
Adjali, Oumeya +8 more
openaire +3 more sources
Arthritis &Rheumatology, EarlyView.Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson +4 more
wiley +1 more source
T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]
PLoS ONE, 2014 Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma +2 more
doaj +1 more source
ADAM8−/− thymi have increased numbers of thymocytes.
, 2013 Numbers of (A) early thymic progenitors (ETP: DN1 ckit+), (B) DN thymocytes, (C) DP thymocytes, (D) CD4 and CD8 thymocytes, (E) semi and late mature CD4 thymocytes and (F) semi and late mature CD8 thymocytes in wt and ADAM8−/− thymi.
Klaus Gossens (376981) +3 more
core +1 more source
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
eLife, 2014 The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein ...
Brenda Y Han +8 more
doaj +1 more source
Increased leptin response and inhibition of apoptosis in thymocytes of young rats offspring from protein deprived dams during lactation. [PDF]
PLoS ONE, 2013 We investigated the consequences of mild maternal malnutrition in rat dams, in terms of thymocyte responses and the putative role of leptin. The young progeny of dams submitted to protein deprivation (PD) during lactation showed at 30 days of age lower ...
Simone Vargas da Silva +6 more
doaj +1 more source
Vav regulates peptide-specific apoptosis in thymocytes. [PDF]
, 1998 The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells.
Ivona Kozieradzki +9 more
core +1 more source
iMetaMed, EarlyView.Shared genetics pathways connect oral diseases and gut disorders. ABSTRACT Oral diseases are highly prevalent and increasingly recognized as contributors to gastrointestinal disorders. Despite clinical observations of oral–gut comorbidity, the underlying genetic architecture and causal mechanisms remain poorly understood.
Rui Zhang +6 more
wiley +1 more source