Mature T‐cell leukemia/lymphoma with an NK‐like immunophenotype: A report of 7 cases
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Distinguishing T‐cell from NK‐cell neoplasms can occasionally be challenging, as neoplastic T cells can lose T‐cell markers such as surface CD3 (sCD3) and CD5 while acquiring NK‐cell markers such as CD16, CD56, and CD94. In this study, we present a series of 7 mature T‐cell lymphoma/leukemia cases with NK‐like immunophenotypes to clarify ...
Wei J. Wang +8 more
wiley +1 more source
Frontiers in Endocrinology, 2018 T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez +8 more
doaj +1 more source
VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model [PDF]
, 2016 Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one. VIP (vasoactive intestinal peptide) has embryotrofic, anti-inflammatory and tolerogenic effects.
Calo, Guillermina +7 more
core +1 more source
Organ Medicine, EarlyView.We developed and validated a preoperative nomogram incorporating NT‐proBNP to predict major adverse cardiovascular events in renal transplant recipients. Using a LASSO‐Cox model based on 582 training and 181 validation cases, we identified NT‐proBNP, age, body mass index, diabetes, and retransplantation as key predictors.
Guobin Wu +9 more
wiley +1 more source
Increased leptin response and inhibition of apoptosis in thymocytes of young rats offspring from protein deprived dams during lactation. [PDF]
PLoS ONE, 2013 We investigated the consequences of mild maternal malnutrition in rat dams, in terms of thymocyte responses and the putative role of leptin. The young progeny of dams submitted to protein deprivation (PD) during lactation showed at 30 days of age lower ...
Simone Vargas da Silva +6 more
doaj +1 more source
Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]
, 1987 Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
Denis, KA, Dorshkind, K, Witte, ON
core +2 more sources
Current Status of Kidney Xenotransplantation in Basic Research
Organ Medicine, EarlyView.Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
eLife, 2014 The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein ...
Brenda Y Han +8 more
doaj +1 more source
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. [PDF]
, 1996 Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells.
Corbella, P +5 more
core
A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter [PDF]
, 2017 Introduction: While most transcripts arising from the human T Cell Receptor locus reflect fully rearranged genes, several germline transcripts have been identified. We describe a new germline transcript arising from the human TCRB locus.
Abarrategui +33 more
core +2 more sources