Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) alpha chains and promotes positive selection of class II-restricted TCR-transgenic thymocytes. [PDF]
, 1998 CD4 contributes to antigen recognition of T cells by binding to class II MHC molecules. There is heterogeneity in expression of CD4 coreceptor among CD4+CD8+ thymocytes.
Mueller, Christoph +4 more
core +1 more source
Mitochondrial uncoupling protein 1 expression in thymocytes [PDF]
, 2008 Using an antibody specific and selective to mitochondrial uncoupling protein 1 (UCP1) peptide, this study confirms the observation that UCP 1 is present in thymocytes isolated from UCP 1 wild-type, but not UCP 1 knock-out mice.
Fallon, Padraic G. +3 more
core +3 more sources
Frontiers in Endocrinology, 2018 T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease.
Ana Rosa Pérez +8 more
doaj +1 more source
In Vivo and Ex Vivo Gene Transfer in Thymocytes and Thymocyte Precursors [PDF]
, 2009 The thymus provides a specialized environment allowing the differentiation of T lymphocytes from bone marrow-derived progenitor cells. We and others have demonstrated that gene transfer into distinct thymocyte populations can be obtained, both in vivo and ex vivo, using lentiviral vectors.
Oumeya, Adjali +8 more
openaire +2 more sources
MiR-181d over-expression reduces the number of DP thymocytes. [PDF]
, 2014 (A) Total thymus cellularity in the control and miR-181d Tg mice. (B) Representative plots show CD4 by CD8 profiles of thymocytes in the control and miR-181d Tg mice, analyzed by FACS. (C) Average percentages of thymocyte subsets (DN, DP, CD4 SP, and CD8
Nicolai S. C. van Oers (196487) +1 more
core +1 more source
T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]
PLoS ONE, 2014 Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma +2 more
doaj +1 more source
Effect of F16-Betulin Conjugate on Mitochondrial Membranes and Its Role in Cell Death Initiation
Membranes, 2021 This work demonstrates the effects of a newly synthesized conjugate of the plant triterpenoid betulin and the penetrating cation F16 used for mitochondrial targeting. The resulting F16-betulin conjugate revealed a mitochondria-targeted effect, decreasing
Mikhail V. Dubinin +5 more
doaj +1 more source
Organ Medicine, EarlyView.Intestinal obstruction (IO) is an important but underexplored complication following simultaneous pancreas‐kidney transplantation (SPKT) and is associated with considerable morbidity and both clinical and economic burdens. In this single‐center cohort study, perioperative parameters, including demographic characteristics, surgical variables, and ...
Rongxin Chen +7 more
wiley +1 more source
Influence of human thymocytes on B-lymphocyte differentiation in man [PDF]
, 1979 Human thymocytes from children less than 6 years of age were tested for their influence on differentiation of normal B cells. The addition of either thymocytes or a culture supernatant from thymocytes to normal peripheral blood lymphocytes (PBL) enhanced
Smithwick, Elizabeth +9 more
core +1 more source
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment
eLife, 2014 The generation of naïve T lymphocytes is critical for immune function yet the mechanisms governing their maturation remain incompletely understood. We have identified a mouse mutant, bloto, that harbors a hypomorphic mutation in the zinc finger protein ...
Brenda Y Han +8 more
doaj +1 more source