Results 71 to 80 of about 45,812 (254)
Pharmaceutics, 2023 The research presents data from a preclinical study on the anti-inflammatory effects of a sodium dichloroacetate and sodium valproate combination (DCA–VPA).
Donatas Stakišaitis +7 more
doaj +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija +6 more
wiley +1 more source
Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel
European Pharmaceutical Journal, 2019 The volume-sensitive outwardly rectifying anion channel (VSOR) is a key component of volume regulation system critical for cell survival in non-isosmotic conditions.
Tsiferova N.A. +8 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2013 Developing thymocytes interact with thymic epithelial cells (TECs) through cell-cell interactions, TEC-derived secretory moieties and extracellular matrix (ECM)-mediated interactions.
Desio Aurelio Farias-de-Oliveira +5 more
doaj +1 more source
Inreased signaling intensity in CD81−/− thymocytes.
, 2012 (a) Deficiency of CD81 or CD9 does not affect T lymphocyte development and thymic cellularity. Thymocytes from B10, CD81−/− and CD9−/− mice were analyzed by multicolor flow cytometry. CD4 vs CD8 contour plots of thymocytes (top row) and lymph node cells (
Emre Deniz (115294) +6 more
core +1 more source
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells [PDF]
, 2010 The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the onset of proliferation and ...
Finlay, David +12 more
core +1 more source
Role of miRNAs in Normal and Myasthenia Gravis Thymus
Frontiers in Immunology, 2020 The thymus, a primary lymphoid organ, provides a complex environment essential for the generation of the T-cell repertoire. Thymic alterations occur during life either in the context of thymic involution upon aging or the pathophysiological context of ...
Mélanie A. Cron +3 more
doaj +1 more source
British Journal of Haematology, EarlyView.After adjusting for confounders, the ibrutinib cohort had significantly better overall survival (adjusted hazard ratio, 0.39; 95% confidence interval, 0.23–0.68; p = 0.0008) than the allogeneic haematopoietic stem cell transplantation (alloHSCT) cohort.
Farrukh T. Awan +8 more
wiley +1 more source
IgM binds strongly to permeabilised non-apoptotic and apoptotic thymocytes.
, 2015 Non-apoptotic and apoptotic mouse thymocytes, induced by overnight culture, were permeabilised with saponin prior to incubation with Balb/c plasma. Permeability was confirmed by PI staining and IgM binding was assessed by flow cytometry.
Jeremy Hughes (478330) +3 more
core +1 more source
Frontiers in Endocrinology, 2018 Maintenance of thymus homeostasis is a delicate interplay involving hormones, neurotransmitters and local microenvironmental proteins, as well as saccharides, acting on both thymocytes and stromal cells.
Ednéa Oliveira-de-Abreu +14 more
doaj +1 more source