Results 1 to 10 of about 58,824 (241)

Generation and Regeneration of Thymic Epithelial Cells [PDF]

Frontiers in Immunology, 2020
The thymus is unique in its ability to support the maturation of phenotypically and functionally distinct T cell sub-lineages. Through its combined production of MHC-restricted conventional CD4+ and CD8+, and Foxp3+ regulatory T cells, as well as non ...
Abdullah S. Alawam, Graham Anderson, Beth Lucas   +2 more
doaj   +5 more sources

Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality [PDF]

Frontiers in Immunology, 2018
Thymic epithelial cells are one of the main components of the thymic microenvironment required for T-cell development. In this work, we describe an efficient method free of enzymatic and Facs-sorted methods to culture human medullary thymic epithelial ...
José A. Villegas, Angeline Gradolatto, Frédérique Truffault, Régine Roussin, Sonia Berrih-Aknin, Rozen Le Panse, Nadine Dragin, Nadine Dragin   +7 more
doaj   +3 more sources

Large-Scale Isolation of Mouse Thymic Epithelial Cells. [PDF]

Methods Mol Biol, 2023
The thymus is compartmentalized into the cortex and the medulla. Cortical and medullary thymic epithelial cells (TECs) characterize T cell-producing and T cell-selecting functions of cortical and medullary microenvironments in the thymus. Enzymatic digestion of the thymus and flow cytometric isolation of TECs and their subpopulations are useful for ...
Ohigashi I, Matsuda-Lennikov M, Takahama Y.   +2 more
europepmc   +3 more sources

Generation and repair of thymic epithelial cells. [PDF]

J Exp Med
In the vertebrate immune system, thymus stromal microenvironments support the generation of αβT cells from immature thymocytes. Thymic epithelial cells are of particular importance, and the generation of cortical and medullary epithelial lineages from progenitor stages controls the initiation and maintenance of thymus function.
Anderson G, Cosway EJ, James KD, Ohigashi I, Takahama Y.   +4 more
europepmc   +3 more sources

Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells [PDF]

Frontiers in Immunology, 2022
Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization.
Alessia Iaiza, Claudia Tito, Federica Ganci, Andrea Sacconi, Enzo Gallo, Silvia Masciarelli, Silvia Masciarelli, Giulia Fontemaggi, Alessandro Fatica, Enrico Melis, Vincenzo Petrozza, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi   +14 more
doaj   +2 more sources

CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo [PDF]

Frontiers in Immunology, 2022
Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymus, large numbers of hematopoietic cells shape the thymic epithelium into a scaffold-like structure which bears little ...
Shicheng Sun, Shicheng Sun, Shicheng Sun, Jacky Y. Li, Jacky Y. Li, Jacky Y. Li, Hieu T. Nim, Hieu T. Nim, Hieu T. Nim, Hieu T. Nim, Adam Piers, Adam Piers, Mirana Ramialison, Mirana Ramialison, Mirana Ramialison, Mirana Ramialison, Enzo R. Porrello, Enzo R. Porrello, Enzo R. Porrello, Enzo R. Porrello, Igor E. Konstantinov, Igor E. Konstantinov, Igor E. Konstantinov, Igor E. Konstantinov, Andrew G. Elefanty, Andrew G. Elefanty, Andrew G. Elefanty, Andrew G. Elefanty, Edouard G. Stanley, Edouard G. Stanley, Edouard G. Stanley, Edouard G. Stanley   +31 more
doaj   +2 more sources

Established thymic epithelial progenitor/stem cell-like cell lines differentiate into mature thymic epithelial cells and support T cell development.

PLoS ONE, 2013
Common thymic epithelial progenitor/stem cells (TEPCs) differentiate into cortical and medullary thymic epithelial cells (TECs), which are required for the development and selection of thymocytes. Mature TEC lines have been widely established.
Pengfei Chen, Jun Zhang, Yu Zhan, Juanjuan Su, Yarui Du, Guoliang Xu, Yufang Shi, Ulrich Siebenlist, Xiaoren Zhang   +8 more
doaj   +3 more sources

The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis [PDF]

Frontiers in Immunology, 2022
Although much progress has been made recently in revealing the heterogeneity of the thymic stromal components, the molecular programs of cell lineage divergency and temporal dynamics of thymic epithelial cell (TEC) development are largely elusive.
Hanchao Gao, Mengtao Cao, Kai Deng, Yang Yang, Jinqi Song, Ming Ni, Chuntao Xie, Wenna Fan, Chunpei Ou, Dinggen Huang, Lizhong Lin, Lixia Liu, Yangyang Li, Huimin Sun, Xinyu Cheng, Jinmei Wu, Cuilan Xia, Xuefeng Deng, Lisha Mou, Pengfei Chen, Pengfei Chen   +20 more
doaj   +2 more sources

The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse. [PDF]

PLoS ONE, 2016
To assess the prerequisites for negative selection of peptidylcitrulline-specific T cells in the thymus. In detail, we here analyzed murine medullary thymic epithelial cells for the expression of peptidylarginine deiminases (PAD) and subsequent ...
Robby Engelmann, Andra Biemelt, Antje Cordshagen, Anja Johl, Daniela Kuthning, Brigitte Müller-Hilke   +5 more
doaj   +1 more source

Metabolic Regulation of Thymic Epithelial Cell Function [PDF]

Frontiers in Immunology, 2021
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stromal cells, including thymic epithelial cells (TECs) are critical for the development of T cell-mediated ...
Manpreet K. Semwal, Nicholas E. Jones, Ann V. Griffith   +2 more
openaire   +3 more sources