Results 1 to 10 of about 35,953 (113)

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Cell Reports, 2019
Summary: The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs).
Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama   +17 more
doaj   +3 more sources

Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells [PDF]

Frontiers in Immunology, 2022
Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization.
Alessia Iaiza, Claudia Tito, Federica Ganci, Andrea Sacconi, Enzo Gallo, Silvia Masciarelli, Silvia Masciarelli, Giulia Fontemaggi, Alessandro Fatica, Enrico Melis, Vincenzo Petrozza, Federico Venuta, Mirella Marino, Giovanni Blandino, Francesco Fazi   +14 more
doaj   +2 more sources

CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo [PDF]

Frontiers in Immunology, 2022
Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymus, large numbers of hematopoietic cells shape the thymic epithelium into a scaffold-like structure which bears little ...
Shicheng Sun, Shicheng Sun, Shicheng Sun, Jacky Y. Li, Jacky Y. Li, Jacky Y. Li, Hieu T. Nim, Hieu T. Nim, Hieu T. Nim, Hieu T. Nim, Adam Piers, Adam Piers, Mirana Ramialison, Mirana Ramialison, Mirana Ramialison, Mirana Ramialison, Enzo R. Porrello, Enzo R. Porrello, Enzo R. Porrello, Enzo R. Porrello, Igor E. Konstantinov, Igor E. Konstantinov, Igor E. Konstantinov, Igor E. Konstantinov, Andrew G. Elefanty, Andrew G. Elefanty, Andrew G. Elefanty, Andrew G. Elefanty, Edouard G. Stanley, Edouard G. Stanley, Edouard G. Stanley, Edouard G. Stanley   +31 more
doaj   +2 more sources

Generation and Regeneration of Thymic Epithelial Cells [PDF]

Frontiers in Immunology, 2020
The thymus is unique in its ability to support the maturation of phenotypically and functionally distinct T cell sub-lineages. Through its combined production of MHC-restricted conventional CD4+ and CD8+, and Foxp3+ regulatory T cells, as well as non ...
Abdullah S. Alawam, Graham Anderson, Beth Lucas   +2 more
doaj   +2 more sources

Transcriptional and epigenetic regulation in thymic epithelial cells. [PDF]

Immunol Rev, 2022
Martinez-Ruíz GU, Morales-Sánchez A, Bhandoola A.   +2 more
europepmc   +2 more sources

Thymosin Beta 15 Alters the Spatial Development of Thymic Epithelial Cells. [PDF]

Cells, 2022
Xu X, He K, Hoffman RD, Ying Y, Tao N, Guo W, Shen J, Liu X, Li M, Yan M, Lv G, Gao J.   +11 more
europepmc   +2 more sources

Generation and repair of thymic epithelial cells. [PDF]

J Exp Med
Anderson G, Cosway EJ, James KD, Ohigashi I, Takahama Y.   +4 more
europepmc   +2 more sources

Experimental model of micronodular thymic neoplasm with lymphoid stroma

Thoracic Cancer, 2023
Background Micronodular thymic neoplasm with lymphoid stroma (MNT), a subtype of thymic tumor, is histopathologically characterized by micronodular thymic epithelial cell nests with lymphoid stroma.
Riko Niwa, Yuki Hanamatsu, Yusuke Kito, Chiemi Saigo, Tamotsu Takeuchi   +4 more
doaj   +1 more source

The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse. [PDF]

PLoS ONE, 2016
To assess the prerequisites for negative selection of peptidylcitrulline-specific T cells in the thymus. In detail, we here analyzed murine medullary thymic epithelial cells for the expression of peptidylarginine deiminases (PAD) and subsequent ...
Robby Engelmann, Andra Biemelt, Antje Cordshagen, Anja Johl, Daniela Kuthning, Brigitte Müller-Hilke   +5 more
doaj   +1 more source

Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. [PDF]

PLoS ONE, 2012
The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recently, it was proposed that autophagy in thymic epithelial cells is essential for the induction of T cell tolerance to self antigens and thus for the ...
Supawadee Sukseree, Michael Mildner, Heidemarie Rossiter, Johannes Pammer, Cheng-Feng Zhang, Ramida Watanapokasin, Erwin Tschachler, Leopold Eckhart   +7 more
doaj   +1 more source