Results 31 to 40 of about 58,824 (241)
First description of cervical intradural thymoma metastasis [PDF]
, 2015 Thymoma and thymic carcinoma are rare epithelial tumors, which originate from the thymus gland. According to the World Health Organization there are "organotypic" (types A, AB, B1, B2, and B3) and "non-organotypic" (thymic carcinomas) thymomas.
Colistra, Davide +5 more
core +1 more source
Immuno, 2022 The normal human thymus originates from the third branchial cleft as two paired anlages that descend into the thorax and fuse on the midline of the anterior–superior mediastinum.
Enzo Gallo +2 more
doaj +1 more source
Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration [PDF]
Frontiers in Immunology, 2020 During gestation, sex hormones cause a significant thymic involution which enhances fertility. This thymic involution is rapidly corrected following parturition. As thymic epithelial cells (TECs) are responsible for the regulation of thymopoiesis, we analyzed the sequential phenotypic and transcriptomic changes in TECs during the postpartum period in ...
Maude Dumont-Lagacé +9 more
openaire +3 more sources
T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica) [PDF]
, 2014 A 10-year-old captive male Siberian tiger (Panthera tigris altaica) presented with acute onset collapse, vomiting and dyspnoea, preceded by a 6-month period of progressive muscle wasting.
A. Routh +31 more
core +1 more source
Key Factors for Thymic Function and Development
Frontiers in Immunology, 2022 The thymus is the organ responsible for T cell development and the formation of the adaptive immunity function. Its multicellular environment consists mainly of the different stromal cells and maturing T lymphocytes.
Valentin P. Shichkin +1 more
doaj +1 more source
Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
PLoS ONE, 2010 Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to weakened immune responses.
Krisztian Kvell +7 more
doaj +1 more source
Frontiers in Immunology, 2020 Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants (RTEs), i.
Anna S. Wilhelmson +14 more
doaj +1 more source
Communications Biology, 2022 Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. Single-cell ATAC-seq of medullary TECs suggests that Sirt6-mediated epigenetic regulation may regulate the development of thymic tuft cells from these TECs.
Qian Zhang +6 more
doaj +1 more source
OVOL2 sustains postnatal thymic epithelial cell identity
Nature Communications, 2023 AbstractDistinct pathways and molecules may support embryonic versus postnatal thymic epithelial cell (TEC) development and maintenance. Here, we identify a mechanism by which TEC numbers and function are maintained postnatally. A viable missense allele (C120Y) of Ovol2, expressed ubiquitously or specifically in TECs, results in lymphopenia, in which T
Xue Zhong +11 more
openaire +3 more sources
PLoS ONE, 2014 Recently, a role of the receptor for advanced glycation endproducts (RAGE) in myasthenia gravis was described. RAGE and its ligand high mobility group box 1 (HMGB1) play key roles in autoimmunity and cancer.
Bernhard Moser +9 more
doaj +1 more source