Results 31 to 40 of about 4,567,849 (254)
Cellularity of Thymic Epithelial Cells in the Postnatal Mouse [PDF]
The Journal of Immunology, 2018 Abstract The molecular and cellular biology of thymic epithelial cells (TECs) often relies on the analysis of TECs isolated in enzymatically digested single-cell suspensions derived from mouse thymus. Many independent studies have reported that the estimated cellularity of total TECs isolated from one adult mouse is on the order of up to
Mie, Sakata +2 more
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Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]
, 1999 Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Downing, James E. G. +4 more
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The role of the transcription factor Sox9 for thymic epithelial cell differentation and function [PDF]
, 2011 The thymus provides throughout life the specialized stromal microenvironment required for the lifelong generation of naïve T cells. This vital function is dependent on the regular composition and organization of its microenvironment, where specialized ...
Žalac, Tatjana
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PLoS ONE, 2013 Common thymic epithelial progenitor/stem cells (TEPCs) differentiate into cortical and medullary thymic epithelial cells (TECs), which are required for the development and selection of thymocytes. Mature TEC lines have been widely established.
Pengfei Chen +8 more
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On the role of "aire" and "smad4" in thymic development [PDF]
, 2006 The thymus is critical for the evolutionary fitness of mammals. It allows the efficient development of T cells, a highly potent defense system, while restraining the developing T cells to prevent self-destruction. In contrast to the extensively studied
Jeker, Lukas Thabo
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Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
PLoS ONE, 2010 Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to weakened immune responses.
Krisztian Kvell +7 more
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Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells. [PDF]
PLoS ONE, 2015 Thymic epithelial cells (TECs) support T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection of developing thymocytes whereas medullary thymic epithelial cells (mTECs) facilitate the deletion of self ...
Imran S Khan +9 more
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Coordinating Development of Medullary Thymic Epithelial Cells [PDF]
Immunity, 2008 Three papers in this issue of Immunity (Akiyama et al., 2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells.
Zhu, Mingzhao, Fu, Yang-Xin
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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. [PDF]
, 2014 Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual
Nusspaumer, G +18 more
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Immuno, 2022 The normal human thymus originates from the third branchial cleft as two paired anlages that descend into the thorax and fuse on the midline of the anterior–superior mediastinum.
Enzo Gallo +2 more
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