Results 1 to 10 of about 35,882 (116)

Medullary Thymic Epithelial Cell Antigen-presentation Assays [PDF]

Bio-Protocol, 2023
Medullary thymic epithelial cells (mTEC) are bona fide antigen-presenting cells that play a crucial role in the induction of T-cell tolerance. By their unique ability to express a broad range of tissue-restricted self-antigens, mTEC control the clonal ...
Alexia Borelli, Cloé Zamit, Magali Irla   +2 more
doaj   +2 more sources

Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality [PDF]

Frontiers in Immunology, 2018
Thymic epithelial cells are one of the main components of the thymic microenvironment required for T-cell development. In this work, we describe an efficient method free of enzymatic and Facs-sorted methods to culture human medullary thymic epithelial ...
José A. Villegas, Angeline Gradolatto, Frédérique Truffault, Régine Roussin, Sonia Berrih-Aknin, Rozen Le Panse, Nadine Dragin, Nadine Dragin   +7 more
doaj   +2 more sources

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Cell Reports, 2019
Summary: A key feature of immune functional impairment with age is the progressive involution of thymic tissue responsible for naive T cell production. In this study, we identify two major phases of thymic epithelial cell (TEC) loss during aging: a block
Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey   +7 more
doaj   +3 more sources

Intrathymic Selection and Defects in the Thymic Epithelial Cell Development. [PDF]

Cells, 2020
García-Ceca J, Montero-Herradón S, Zapata AG.   +2 more
europepmc   +2 more sources

Experimental model of micronodular thymic neoplasm with lymphoid stroma

Thoracic Cancer, 2023
Background Micronodular thymic neoplasm with lymphoid stroma (MNT), a subtype of thymic tumor, is histopathologically characterized by micronodular thymic epithelial cell nests with lymphoid stroma.
Riko Niwa, Yuki Hanamatsu, Yusuke Kito, Chiemi Saigo, Tamotsu Takeuchi   +4 more
doaj   +1 more source

The Lineage Differentiation and Dynamic Heterogeneity of Thymic Epithelial Cells During Thymus Organogenesis

Frontiers in Immunology, 2022
Although much progress has been made recently in revealing the heterogeneity of the thymic stromal components, the molecular programs of cell lineage divergency and temporal dynamics of thymic epithelial cell (TEC) development are largely elusive.
Hanchao Gao, Mengtao Cao, Kai Deng, Yang Yang, Jinqi Song, Ming Ni, Chuntao Xie, Wenna Fan, Chunpei Ou, Dinggen Huang, Lizhong Lin, Lixia Liu, Yangyang Li, Huimin Sun, Xinyu Cheng, Jinmei Wu, Cuilan Xia, Xuefeng Deng, Lisha Mou, Pengfei Chen, Pengfei Chen   +20 more
doaj   +1 more source

Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice

Frontiers in Immunology, 2020
Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants (RTEs), i.
Anna S. Wilhelmson, Marta Lantero Rodriguez, Inger Johansson, Elin Svedlund Eriksson, Alexandra Stubelius, Alexandra Stubelius, Susanne Lindgren, Susanne Lindgren, Johan Bourghardt Fagman, Pamela J. Fink, Hans Carlsten, Hans Carlsten, Olov Ekwall, Olov Ekwall, Åsa Tivesten   +14 more
doaj   +1 more source

Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs

Journal of Immunology Research, 2022
In paradox to critical functions for T-cell selection and self-tolerance, the thymus undergoes profound age-associated atrophy and loss of T-cell function, further enhanced by cancer therapies. Identifying thymic epithelial progenitor populations capable
Shami Chakrabarti, Mohammed Hoque, Nawshin Zara Jamil, Varan J. Singh, Daniel Pollacksmith, Neelab Meer, Mark T. Pezzano   +6 more
doaj   +1 more source

Rac1 deletion causes thymic atrophy.

PLoS ONE, 2011
The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood.
Lukas Hunziker, Salvador Aznar Benitah, Kristin M Braun, Kim Jensen, Katrina McNulty, Colin Butler, Elspeth Potton, Emma Nye, Richard Boyd, Geoff Laurent, Michael Glogauer, Nick A Wright, Fiona M Watt, Sam M Janes   +13 more
doaj   +1 more source

Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution

Cell Reports, 2014
Summary: Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown.
Sanghee Ki, Daechan Park, Hilary J. Selden, Jun Seita, Haewon Chung, Jonghwan Kim, Vishwanath R. Iyer, Lauren I.R. Ehrlich   +7 more
doaj   +1 more source