Results 41 to 50 of about 5,098,470 (266)

Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]

, 2010
Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
core   +1 more source

Long-term persistence of functional thymic epithelial progenitor cells in vivo under conditions of low FOXN1 expression.

PLoS ONE, 2014
Normal thymus function reflects interactions between developing T-cells and several thymic stroma cell types. Within the stroma, key functions reside in the distinct cortical and medullary thymic epithelial cell (TEC) types. It has been demonstrated that,
Xin Jin, Craig S Nowell, Svetlana Ulyanchenko, Frances H Stenhouse, C Clare Blackburn   +4 more
doaj   +1 more source

The Murine Epithelial Thymic Microenvironment Is Governed by Eph/Ephrin Signalling

Cells
Although the relevance of thymic epithelial cell–thymocyte interactions for thymus function has long been emphasised, the mechanisms that govern the biology of thymic epithelial cells (TECs) are not fully understood.
Sara Montero-Herradón, David Alfaro, Agustín G. Zapata, Javier García-Ceca   +3 more
doaj   +1 more source

Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas.

PLoS ONE, 2019
The pathogenesis of thymic epithelial tumors remains poorly elucidated. The PIK3/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II studies have reported a positive effect of mTOR inhibitors in disease control in ...
Jean-Michel Maury, Claire Merveilleux du Vignaux, Gabrielle Drevet, Virginie Zarza, Lara Chalabreysse, Carine Maisse, Barbara Gineys, Christine Dolmazon, François Tronc, Nicolas Girard, Caroline Leroux   +10 more
doaj   +1 more source

Meis1 is required for the maintenance of postnatal thymic epithelial cells.

PLoS ONE, 2014
Most epithelial tissues retain stem/progenitor cells to maintain homeostasis of the adult tissues; however, the existence of a thymic epithelial cell (TEC) progenitor capable of maintaining homeostasis of the postnatal thymus remains unclear.
Takehiro Hirayama, Yusuke Asano, Hajime Iida, Takeshi Watanabe, Takuro Nakamura, Ryo Goitsuka   +5 more
doaj   +1 more source

Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]

, 2008
The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg, Habu, S., Holländer, G. A., Hozumi, K., Hirano, K, Mailhos, C, Ken-ichi Hirano, Negishi, N, Saulius Zuklys, Habu, S, Zuklys, S, Yahata, T., Sonoko Habu, Mailhos, C., Georg A. Holländer, Naoko Negishi, Ando, K., Ando, K, Kiyoshi Ando, Holländer, GA, Shima, D. T., Negishi, N., Carolina Mailhos, Hozumi, K, Yahata, T, Shima, DT, Hirano, K., Katsuto Hozumi, Takashi Yahata, David T. Shima, Zuklys, S.   +30 more
core   +1 more source

Clinical and Immunologic Features of Primary Enteric-Type Thymic Adenocarcinomas: A Rare Variant of a Rare Cancer

JTO Clinical and Research Reports
Introduction: Primary thymic adenocarcinomas are a rare subtype of thymic carcinoma, which share morphologic and immunohistochemical features with gastrointestinal cancers.
Alisa K. Sivapiromrat, BS, Meredith J. McAdams, MD, Renee N. Donahue, PhD, Carolina Celades, MD, Wiem Lassoued, PhD, Hana Bagheri, MS, Elsa Bahiru, MPH, MSN, AGCNP, Shannon Swift, RN, BSN, Christine Feierabend, RN, Susan Sansone, BA, Laercio DaSilva, MD, Eva Szabo, MD, Chen Zhao, MD, Jeffrey Schlom, PhD, James L. Gulley, MD, PhD, Arun Rajan, MD   +15 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Heterogeneity in thymic emigrants: implications for thymectomy and immunosenescence. [PDF]

, 2013
The development of mature, antigen-inexperienced (naive) T cells begins in the thymus and continues after export into the periphery. Post-thymic maturation of naive T cells, in humans, coincides with the progressive loss of markers such as protein ...
Iren Bains (382649), Bains, Iren, Callard, Robin E., Andrew J Yates, Yates, AJ, Iren Bains, Yates, Andrew J., Robin E Callard, Callard, RE, Andrew J. Yates (195608), Robin E. Callard (382650), Bains, I   +11 more
core   +2 more sources