Results 21 to 30 of about 5,098,470 (266)

Checkpoints in the Development of Thymic Cortical Epithelial Cells [PDF]

The Journal of Immunology, 2009
Abstract In the thymus, interactions between immature thymocytes and thymic epithelial cells (TECs) regulate the development and selection of self-tolerant MHC-restricted T cells. Despite the importance of cortical (cTEC) and medullary (mTEC) thymic epithelial cells in fostering T cell production, events in TEC development are still ...
Saba, Shakib, Guillaume E, Desanti, William E, Jenkinson, Sonia M, Parnell, Eric J, Jenkinson, Graham, Anderson   +5 more
openaire   +3 more sources

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

Characterization of the spatio-temporal dynamics in thymic epithelial development [PDF]

, 2015
The work presented in this thesis is centered on the development and maturation of the epithelial compartment in the murine thymus and consequently its functional capacity to promote normal thymopoiesis. Two main aspects have been investigated in depth:
Mayer, Carlos E.
core   +1 more source

DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration. [PDF]

PLoS ONE, 2010
Thymic epithelial cell (TEC) microenvironments are essential for the recruitment of T cell precursors from the bone marrow, as well as the subsequent expansion and selection of thymocytes resulting in a mature self-tolerant T cell repertoire.
Masako Osada, Logan Jardine, Ruth Misir, Thomas Andl, Sarah E Millar, Mark Pezzano   +5 more
doaj   +1 more source

Key Factors for Thymic Function and Development

Frontiers in Immunology, 2022
The thymus is the organ responsible for T cell development and the formation of the adaptive immunity function. Its multicellular environment consists mainly of the different stromal cells and maturing T lymphocytes.
Valentin P. Shichkin, Mariastefania Antica   +1 more
doaj   +1 more source

Function of Gata-2 in thymic epithelial cells : a transcription factor identified from gene expression analysis of endodermal cells committed to thymic epithelial cell fate [PDF]

, 2010
The thymus structure composes of clear morphological regions. The T-cell precursors enter the thymus in the cortico-medullary junction and migrate through the cortex towards the sub capsular region and back through to the cortex into the medulla.
Na, Kyung-Jae
core   +1 more source

CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo

Frontiers in Immunology, 2022
Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymus, large numbers of hematopoietic cells shape the thymic epithelium into a scaffold-like structure which bears little ...
Shicheng Sun, Shicheng Sun, Shicheng Sun, Jacky Y. Li, Jacky Y. Li, Jacky Y. Li, Hieu T. Nim, Hieu T. Nim, Hieu T. Nim, Hieu T. Nim, Adam Piers, Adam Piers, Mirana Ramialison, Mirana Ramialison, Mirana Ramialison, Mirana Ramialison, Enzo R. Porrello, Enzo R. Porrello, Enzo R. Porrello, Enzo R. Porrello, Igor E. Konstantinov, Igor E. Konstantinov, Igor E. Konstantinov, Igor E. Konstantinov, Andrew G. Elefanty, Andrew G. Elefanty, Andrew G. Elefanty, Andrew G. Elefanty, Edouard G. Stanley, Edouard G. Stanley, Edouard G. Stanley, Edouard G. Stanley   +31 more
doaj   +1 more source

Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution [PDF]

, 2010
The thymus constitutes the primary lymphoid organ responsible for the generation of naïve T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for ...
Hauri-Hohl, Mathias Martin
core   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Jeker, LT, Lei, Y., Jeker, L. T., Lei, Y, Georg A. Holländer, Ishimaru, N, Holländer, GA, Bösl, MR, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Malefyt, RW, Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Takahama, Y, Nagasawa, T., Nitta, T, Nagasawa, T, Izumi Ohigashi, Ripen, A. M., Hayashi, Y, Ohigashi, I., Malefyt, R. D., Takashi Nagasawa, Malefyt Rde, W., Ohigashi, I, Ripen, AM, Adiratna Mat Ripen   +36 more
core   +1 more source

Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]

, 2014
Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core   +1 more source