Results 11 to 20 of about 5,098,470 (266)
Generation and Regeneration of Thymic Epithelial Cells [PDF]
Frontiers in Immunology, 2020 The thymus is unique in its ability to support the maturation of phenotypically and functionally distinct T cell sub-lineages. Through its combined production of MHC-restricted conventional CD4+ and CD8+, and Foxp3+ regulatory T cells, as well as non ...
Abdullah S. Alawam +2 more
doaj +3 more sources
Identification and Characterization of Thymic Epithelial Progenitor Cells [PDF]
Immunity, 2002 T cell differentiation and repertoire selection depend critically on several distinct thymic epithelial cell types, whose lineage relationships are unclear.
Blair, Natalie F. +5 more
core +4 more sources
The Antigenic Determinant That Defines Thymic Nurse Cells Is Expressed by Thymic Epithelial Progenitor Cells [PDF]
Frontiers in Cell and Developmental Biology, 2014 Stromal thymic epithelial cells with the multicellular structure unique to thymic nurse cells (TNCs) express the pH91 antigen on their cell surfaces.
Rajendra V.E Chilukuri +4 more
doaj +3 more sources
PLoS ONE, 2013 Common thymic epithelial progenitor/stem cells (TEPCs) differentiate into cortical and medullary thymic epithelial cells (TECs), which are required for the development and selection of thymocytes. Mature TEC lines have been widely established.
Pengfei Chen +8 more
doaj +2 more sources
The development and function of thymic microenvironments [PDF]
, 2009 The thymus is organised into distinct microenvironments, and trafficking through these regions enables thymocytes to receive essential signals for the generation of a diverse and self-tolerant T-cell repertoire.
Shakib, Saba
core +7 more sources
Metabolic Regulation of Thymic Epithelial Cell Function. [PDF]
Front Immunol, 2021 The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stromal cells, including thymic epithelial cells (TECs) are critical for the development of T cell-mediated ...
Semwal MK, Jones NE, Griffith AV.
europepmc +5 more sources
Generation of diversity in thymic epithelial cells [PDF]
Nature Reviews Immunology, 2017 In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells.
Yousuke, Takahama +3 more
openaire +2 more sources
A roadmap for thymic epithelial cell development [PDF]
European Journal of Immunology, 2009 AbstractThymic epithelial cells (TEC) are essential components of the thymus that guide and control the development and TCR repertoire selection of T cells. Previously, TEC have been considered as postmitotic cells that, once generated during ontogeny, were maintained in their mature state.
Graham, Anderson +2 more
openaire +2 more sources
Multi-Omics Integration Identifies a CDH3-Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors. [PDF]
Adv Sci (Weinh)Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Feng Y +13 more
europepmc +2 more sources
In Pursuit of Adult Progenitors of Thymic Epithelial Cells [PDF]
Frontiers in Immunology, 2021 Peripheral T cells capable of discriminating between self and non-self antigens are major components of a robust adaptive immune system. The development of self-tolerant T cells is orchestrated by thymic epithelial cells (TECs), which are localized in the thymic cortex (cortical TECs, cTECs) and medulla (medullary TECs, mTECs).
Tatsuya Ishikawa +4 more
openaire +3 more sources