Results 31 to 40 of about 5,098,470 (266)
Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
PLoS ONE, 2010 Age-associated thymic involution has considerable physiological impact by inhibiting de novo T-cell selection. This impaired T-cell production leads to weakened immune responses.
Krisztian Kvell +7 more
doaj +1 more source
The role of the transcription factor Sox9 for thymic epithelial cell differentation and function [PDF]
, 2011 The thymus provides throughout life the specialized stromal microenvironment required for the lifelong generation of naïve T cells. This vital function is dependent on the regular composition and organization of its microenvironment, where specialized ...
Žalac, Tatjana
core +1 more source
Cellularity of Thymic Epithelial Cells in the Postnatal Mouse [PDF]
The Journal of Immunology, 2018 Abstract The molecular and cellular biology of thymic epithelial cells (TECs) often relies on the analysis of TECs isolated in enzymatically digested single-cell suspensions derived from mouse thymus. Many independent studies have reported that the estimated cellularity of total TECs isolated from one adult mouse is on the order of up to
Mie, Sakata +2 more
openaire +2 more sources
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. [PDF]
, 2014 Promiscuous gene expression (PGE) by thymic epithelial cells (TEC) is essential for generating a diverse T cell antigen receptor repertoire tolerant to self-antigens, and thus for avoiding autoimmunity. Nevertheless, the extent and nature of this unusual
Nusspaumer, G +18 more
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Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]
, 1999 Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Downing, James E. G. +4 more
core +1 more source
On the role of "aire" and "smad4" in thymic development [PDF]
, 2006 The thymus is critical for the evolutionary fitness of mammals. It allows the efficient development of T cells, a highly potent defense system, while restraining the developing T cells to prevent self-destruction. In contrast to the extensively studied
Jeker, Lukas Thabo
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Coordinating Development of Medullary Thymic Epithelial Cells [PDF]
Immunity, 2008 Three papers in this issue of Immunity (Akiyama et al., 2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells.
Zhu, Mingzhao, Fu, Yang-Xin
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The role of the transcription factor Foxn1 in Thymus organogenesis and maintenance [PDF]
, 2014 The thymus is the primary lymphoid organ responsible for T-cell development and selection, which requires a specialised stromal microenvironment. The thymic stroma consists mainly of thymic epithelial cells (TEC), which can be divided into cortical (c ...
Bosch, Angela Jeanne Tamara
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p73 Is Expressed in Human Thymic Epithelial Cells [PDF]
Journal of Histochemistry & Cytochemistry, 2002 The thymus is a heterogeneous immune organ in which immature T-cells develop and eventually specialize to make certain immune responses of their own. Among various types of stromal cells in the thymus, thymic epithelial cells (TECs) have a crucially important function for presenting self-antigens and secreting cytokines to thymocytes for their ...
Shingo, Ichimiya +8 more
openaire +2 more sources
Transcriptome sequencing of neonatal thymic epithelial cells [PDF]
Scientific Reports, 2013 In order to gain novel insights into thymus biology, we analysed the whole transcriptome of cortical and medullary thymic epithelial cells (cTECs and mTECs) and of skin epithelial cells (ECs). Consistent with their ability to express ectopic genes, mTECs expressed more genes than other cell populations. Out of a total of 15,069 genes expressed in TECs,
Charles St-Pierre +5 more
openaire +2 more sources