Results 11 to 20 of about 4,567,849 (254)
The Antigenic Determinant That Defines Thymic Nurse Cells Is Expressed by Thymic Epithelial Progenitor Cells [PDF]
Frontiers in Cell and Developmental Biology, 2014 Stromal thymic epithelial cells with the multicellular structure unique to thymic nurse cells (TNCs) express the pH91 antigen on their cell surfaces.
Rajendra V.E Chilukuri +4 more
doaj +7 more sources
Rac1 deletion causes thymic atrophy. [PDF]
PLoS ONE, 2011 The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood.
Lukas Hunziker +13 more
doaj +2 more sources
High efficiency transfection of thymic epithelial cell lines and primary thymic epithelial cells by Nucleofection [PDF]
Nature Precedings, 2011 Abstract Thymic epithelial cells (TECs) are required for the development and differentiation of T cells and are sufficient for the positive and negative selection of developing T cells. Although TECs play a critical role in T cell biology, simple, efficient and readily scalable methods for the transfection of TEC ...
ONeil, Richard T +2 more
core +4 more sources
Cultured Human Thymic-Derived Cells Display Medullary Thymic Epithelial Cell Phenotype and Functionality [PDF]
Frontiers in Immunology, 2018 Thymic epithelial cells are one of the main components of the thymic microenvironment required for T-cell development. In this work, we describe an efficient method free of enzymatic and Facs-sorted methods to culture human medullary thymic epithelial ...
José A. Villegas +7 more
doaj +2 more sources
The development and function of thymic microenvironments [PDF]
, 2009 The thymus is organised into distinct microenvironments, and trafficking through these regions enables thymocytes to receive essential signals for the generation of a diverse and self-tolerant T-cell repertoire.
Shakib, Saba
core +7 more sources
AIRE illuminates the feature of medullary thymic epithelial cells in thymic carcinoma. [PDF]
Cancer Med, 2023 AbstractDespite the clear distinction between cortical (cTECs) and medullary thymic epithelial cells (mTECs) in physiology, the cell of origin of thymic carcinomas (TCs) and other thymic epithelial tumors remained enigmatic. We addressed this issue by focusing on AIRE, an mTEC‐specific transcriptional regulator that is required for immunological self ...
Matsumoto M +10 more
europepmc +4 more sources
Generation of diversity in thymic epithelial cells [PDF]
Nature Reviews Immunology, 2017 In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells.
Yousuke, Takahama +3 more
openaire +2 more sources
In Pursuit of Adult Progenitors of Thymic Epithelial Cells. [PDF]
Front Immunol, 2021 Peripheral T cells capable of discriminating between self and non-self antigens are major components of a robust adaptive immune system. The development of self-tolerant T cells is orchestrated by thymic epithelial cells (TECs), which are localized in the thymic cortex (cortical TECs, cTECs) and medulla (medullary TECs, mTECs).
Ishikawa T, Akiyama N, Akiyama T.
europepmc +5 more sources
A roadmap for thymic epithelial cell development [PDF]
European Journal of Immunology, 2009 AbstractThymic epithelial cells (TEC) are essential components of the thymus that guide and control the development and TCR repertoire selection of T cells. Previously, TEC have been considered as postmitotic cells that, once generated during ontogeny, were maintained in their mature state.
Graham, Anderson +2 more
openaire +2 more sources
Checkpoints in the Development of Thymic Cortical Epithelial Cells [PDF]
The Journal of Immunology, 2009 Abstract In the thymus, interactions between immature thymocytes and thymic epithelial cells (TECs) regulate the development and selection of self-tolerant MHC-restricted T cells. Despite the importance of cortical (cTEC) and medullary (mTEC) thymic epithelial cells in fostering T cell production, events in TEC development are still ...
Saba, Shakib +5 more
openaire +3 more sources