High efficiency transfection of thymic epithelial cell lines and primary thymic epithelial cells by Nucleofection [PDF]
Nature Precedings, 2011 AbstractThymic epithelial cells (TECs) are required for the development and differentiation of T cells and are sufficient for the positive and negative selection of developing T cells. Although TECs play a critical role in T cell biology, simple, efficient and readily scalable methods for the transfection of TEC lines and primary TECs have not been ...
ONeil, Richard T +2 more
core +4 more sources
Generation of diversity in thymic epithelial cells [PDF]
Nature Reviews Immunology, 2017 In the thymus, diverse populations of thymic epithelial cells (TECs), including cortical and medullary TECs and their subpopulations, have distinct roles in coordinating the development and repertoire selection of functionally competent and self-tolerant T cells.
Yousuke, Takahama +3 more
openaire +4 more sources
Identification and Characterization of Thymic Epithelial Progenitor Cells [PDF]
Immunity, 2002 T cell differentiation and repertoire selection depend critically on several distinct thymic epithelial cell types, whose lineage relationships are unclear. We have investigated these relationships via functional analysis of the epithelial populations within the thymic primordium.
Bennett, Andrea R. +5 more
openaire +4 more sources
Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells. [PDF]
Cell, 2022 Michelson DA +4 more
europepmc +2 more sources
Experimental model of micronodular thymic neoplasm with lymphoid stroma
Thoracic Cancer, 2023 Background Micronodular thymic neoplasm with lymphoid stroma (MNT), a subtype of thymic tumor, is histopathologically characterized by micronodular thymic epithelial cell nests with lymphoid stroma.
Riko Niwa +4 more
doaj +1 more source
Immunodeficiency in DiGeorge Syndrome and Options for Treating Cases with Complete Athymia. [PDF]
, 2013 The commonest association of thymic stromal deficiency resulting in T-cell immunodeficiency is the DiGeorge syndrome (DGS). This results from abnormal development of the third and fourth pharyngeal arches and is most commonly associated with a ...
Davies, EG
core +10 more sources
Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. [PDF]
PLoS ONE, 2012 The thymic epithelium plays critical roles in the positive and negative selection of T cells. Recently, it was proposed that autophagy in thymic epithelial cells is essential for the induction of T cell tolerance to self antigens and thus for the ...
Supawadee Sukseree +7 more
doaj +1 more source
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +1 more source
Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs
Journal of Immunology Research, 2022 In paradox to critical functions for T-cell selection and self-tolerance, the thymus undergoes profound age-associated atrophy and loss of T-cell function, further enhanced by cancer therapies. Identifying thymic epithelial progenitor populations capable
Shami Chakrabarti +6 more
doaj +1 more source
BMC Cancer, 2023 Background The classification of thymomas is based on the morphology of epithelial tumor cells and the proportion of lymphocytes. Type A thymomas are composed of the spindle or oval tumor epithelial cells. Tumor cells of B thymomas are epithelioid-shaped
Huiyang Li +4 more
doaj +1 more source