Results 41 to 50 of about 58,824 (241)
Human thymic epithelial cells produce interleukin-3 [PDF]
Blood, 1991 Abstract Interleukin-3 (IL-3) is a hematopoietic growth factor suggested to be produced by activated T lymphocytes. Meanwhile, supernatants from human thymic stroma could promote the proliferation of myeloid stem cells. Thus, we investigated whether IL-3 accounts for this activity.
A H, Dalloul +6 more
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Bioengineering thymus organoids to restore thymic function and induce donor-specific immune tolerance to allografts [PDF]
, 2015 One of the major obstacles in organ transplantation is to establish immune tolerance of allografts. Although immunosuppressive drugs can prevent graft rejection to a certain degree, their efficacies are limited, transient, and associated with severe side
Alpdogan +82 more
core +1 more source
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
Cell Reports, 2019 Summary: The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs).
Izumi Ohigashi +17 more
doaj +1 more source
Oestrogen, an evolutionary conserved regulator of T cell differentiation and immune tolerance in jawed vertebrates? [PDF]
, 2018 In teleosts, as in mammals, the immune system is tightly regulated by sexual steroid hormones, such as oestrogens. We investigated the effects of 17β-oestradiol on the expression of several genes related to T cell development and resulting T cell ...
Duflot, Aurélie +5 more
core +3 more sources
Scientific Reports, 2017 Activated T cells have been shown to be able to recirculate into the thymus from the periphery. The present study was aimed to elucidate the functional consequences of thymic homing of activated T cells upon developing thymocytes and thymic epithelial ...
Chen Yin +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2014 Stromal thymic epithelial cells with the multicellular structure unique to thymic nurse cells (TNCs) express the pH91 antigen on their cell surfaces.
Rajendra V.E Chilukuri +4 more
doaj +1 more source
A roadmap for thymic epithelial cell development [PDF]
European Journal of Immunology, 2009 AbstractThymic epithelial cells (TEC) are essential components of the thymus that guide and control the development and TCR repertoire selection of T cells. Previously, TEC have been considered as postmitotic cells that, once generated during ontogeny, were maintained in their mature state.
Graham, Anderson +2 more
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Thymoma metastatic to liver and pancreas: case report and review of the literature [PDF]
, 2017 A 71-year-old man presented with a thymic mass involving the superior vena cava. A mediastinoscopical biopsy initially suggested a diagnosis of type A thymoma.
Blandamura, Stella +4 more
core +1 more source
GPR109A expressed on medullary thymic epithelial cells affects thymic Treg development
European Journal of Immunology, 2023 AbstractRegulatory T cells (Treg) maintain immune homeostasis due to their anti‐inflammatory functions. They can be generated either centrally in the thymus or in peripheral organs. Metabolites such as short‐chain fatty acids produced by intestinal microbiota can induce peripheral Treg differentiation, by activating G‐protein‐coupled‐receptors like ...
Duan Ni +12 more
openaire +2 more sources
Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans
Topics in Cognitive Science, EarlyView., 2023 Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica +3 more
wiley +1 more source