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The role of the transcription factor Foxn1 in Thymus organogenesis and maintenance [PDF]
, 2014 The thymus is the primary lymphoid organ responsible for T-cell development and selection, which requires a specialised stromal microenvironment. The thymic stroma consists mainly of thymic epithelial cells (TEC), which can be divided into cortical (c ...
Bosch, Angela Jeanne Tamara
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Frontiers in Immunology, 2020 Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants (RTEs), i.
Anna S. Wilhelmson +14 more
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p73 Is Expressed in Human Thymic Epithelial Cells [PDF]
Journal of Histochemistry & Cytochemistry, 2002 The thymus is a heterogeneous immune organ in which immature T-cells develop and eventually specialize to make certain immune responses of their own. Among various types of stromal cells in the thymus, thymic epithelial cells (TECs) have a crucially important function for presenting self-antigens and secreting cytokines to thymocytes for their ...
Shingo, Ichimiya +8 more
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Scientific Reports, 2017 Activated T cells have been shown to be able to recirculate into the thymus from the periphery. The present study was aimed to elucidate the functional consequences of thymic homing of activated T cells upon developing thymocytes and thymic epithelial ...
Chen Yin +7 more
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PLoS ONE, 2014 Recently, a role of the receptor for advanced glycation endproducts (RAGE) in myasthenia gravis was described. RAGE and its ligand high mobility group box 1 (HMGB1) play key roles in autoimmunity and cancer.
Bernhard Moser +9 more
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Transcriptome sequencing of neonatal thymic epithelial cells [PDF]
Scientific Reports, 2013 In order to gain novel insights into thymus biology, we analysed the whole transcriptome of cortical and medullary thymic epithelial cells (cTECs and mTECs) and of skin epithelial cells (ECs). Consistent with their ability to express ectopic genes, mTECs expressed more genes than other cell populations. Out of a total of 15,069 genes expressed in TECs,
Charles St-Pierre +5 more
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Characterization of the function of thymic stromal lymphopoietin in lymphopoiesis and lymph node organogenesis [PDF]
, 2010 Interleukin (IL)-7 is a cytokine, which is crucial for the development of the murine immune system. It is required for lymphopoiesis and for the development of peripheral lymph nodes (LN). IL-7-/-mice have impaired B and T cell lymphopoiesis, decreased
Chappaz, Stéphane
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Key Factors for Thymic Function and Development
Frontiers in Immunology, 2022 The thymus is the organ responsible for T cell development and the formation of the adaptive immunity function. Its multicellular environment consists mainly of the different stromal cells and maturing T lymphocytes.
Valentin P. Shichkin +1 more
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Communications Biology, 2022 Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. Single-cell ATAC-seq of medullary TECs suggests that Sirt6-mediated epigenetic regulation may regulate the development of thymic tuft cells from these TECs.
Qian Zhang +6 more
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Heterogeneity in thymic emigrants: implications for thymectomy and immunosenescence. [PDF]
, 2013 The development of mature, antigen-inexperienced (naive) T cells begins in the thymus and continues after export into the periphery. Post-thymic maturation of naive T cells, in humans, coincides with the progressive loss of markers such as protein ...
Iren Bains (382649) +11 more
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