Results 51 to 60 of about 58,824 (241)

Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells

BMC Medicine, 2011
Pluripotent stem cells have the capacity to generate all cell lineages, and substantial progress has been made in realizing this potential. One fascinating but as yet unrealized possibility is the differentiation of pluripotent stem cells into thymic ...
Snoeck Hans-Willem, Green Michael D
doaj   +1 more source

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) is pivotal to the pathophysiology of widespread allergic diseases mediated by type 2 helper T cell (Th2) responses, including asthma and atopic dermatitis. The emergence of human TSLP as a
Beyaert, Rudi, Braun, Harald, Dansercoer, Ann, De Winter, Hans, Hammad, Hamida, Lambrecht, Bart, Lippens, Guy, Lopez, Juan, Pauwels, Kris, Peelman, Frank, Savvides, Savvas, Tavernier, Jan, Van Rompaey, Dries, Vandenberghe, Isabel, Verstraete, Kenneth   +14 more
core   +3 more sources

Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b) [PDF]

, 2009
Cyclin D1b is an alternative transcript of the cyclin D1 gene (CCND1) expressed in human tumors. Its abundance is regulated by a single base pair polymorphism at the exon 4/intron 4 boundary (nucleotide 870).
Benavides, Fernando, Blando, Jorge, Cardenas, Kim, Conti, Claudio, Johnson, David G., Knudsen, Erik S., Pérez, Carlos, Richie, Ellen, Rodriguez Puebla, Marcelo L., Rojas, Paola Andrea, Senderowicz, Adrian M.   +10 more
core   +1 more source

Probing gene function in thymic epithelial cells

European Journal of Cell Biology, 2012
Thymic epithelial cells (TECs) provide a highly specialized microenvironment for the generation of a functional and self-tolerant T cell repertoire. Much of our current view of TEC biology is derived from gain- or loss-of-function approaches, which have significantly contributed to our understanding of gene function in TEC development and T cell ...
Martin, Aichinger, Maria, Hinterberger, Ludger, Klein   +2 more
openaire   +2 more sources

Effects of exosomes of paratumoral thymus epithelial cells on Treg cell function in patients with thymoma-associated myasthenia gravis

Guangxi Yike Daxue xuebao
Objective To investigate the effects of exosomes derived from paratumoral thymic epithelial cells on the expression of forkhead box protein P3 (FOXP3) and the secretion of transforming growth factor-beta1 (TGF-β1) and interleukin (IL)-10 by regulatory T ...
CHEN Liuling, TAN Shuting, BAO Xiaoran, LIU Jingli, LI Jinpin   +4 more
doaj   +1 more source

Activation of the mTOR/ Akt pathway in thymic epithelial cells derived from thymomas.

PLoS ONE, 2019
The pathogenesis of thymic epithelial tumors remains poorly elucidated. The PIK3/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II studies have reported a positive effect of mTOR inhibitors in disease control in ...
Jean-Michel Maury, Claire Merveilleux du Vignaux, Gabrielle Drevet, Virginie Zarza, Lara Chalabreysse, Carine Maisse, Barbara Gineys, Christine Dolmazon, François Tronc, Nicolas Girard, Caroline Leroux   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Thymus transplantation for complete DiGeorge syndrome: European experience [PDF]

, 2017
Background: Thymus transplantation is a promising strategy for the treatment of athymic complete DiGeorge syndrome (cDGS). Methods: Twelve patients with cDGS were transplanted with allogeneic cultured thymus.
Adrian J. Thrasher, Alina Papadopol, Amrolia, Anderson, Anna Furmanski, Austen Worth, Blythe Devlin, David M. Sansom, Davies, Despina Moshous, E. Graham Davies, Elizabeth McCarthy, Furmanski, H. Bobby Gaspar, Hans Christian Erichsen, Hassan, Hassan, Heino, Ida Ricciardelli, Janda, Jesmeen Maimaris, Joe Curry, Jolanta Bernatoniene, Kathryn L. Parsley, Kim Neuling, Kimberly Gilmour, King, Konstantinos Mengrelis, Lizzie Hutchison, Luigi Poliani, M. Louise Markert, Malgorzata Pac, Marianne Ifversen, Markert, Markert, Markert, Markert, Markert, Markert, Markert, McGhee, Melissa Cheung, Michael Browning, Morbach, Morbach, Neil Halliday, Neil Sebire, Poliani, Ronald Bremner, Rucci, Ryan, Schubert, Shearer, Shearer, Stuart Adams, T. Ronan Leahy, Tessa Crompton, Tiia Voor, Winnie Ip, Yang   +59 more
core   +3 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]

, 2013
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A, Lund, Sean, Walford, Hannah H   +2 more
core   +2 more sources