Results 21 to 30 of about 58,824 (241)

Use of the complex of models of regression for analysis of the factors that determine the severity of bronchial asthma [PDF]

, 2020
Background: According to an International Study of Asthma and Allergies in Childhood (ISAAC), the prevalence of asthma in children of 6-7 years old has increased by 10%, and at the age of 13-14 years by 16% over the last decade.
Kozhyna, Olga S., Pihnastyi, O. M.
core   +2 more sources

Transcriptome sequencing of neonatal thymic epithelial cells [PDF]

Scientific Reports, 2013
In order to gain novel insights into thymus biology, we analysed the whole transcriptome of cortical and medullary thymic epithelial cells (cTECs and mTECs) and of skin epithelial cells (ECs). Consistent with their ability to express ectopic genes, mTECs expressed more genes than other cell populations. Out of a total of 15,069 genes expressed in TECs,
Charles St-Pierre, Sylvie Brochu, Juan Ruiz Vanegas, Maude Dumont-Lagacé, Sébastien Lemieux, Claude Perreault   +5 more
openaire   +2 more sources

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Brucker, Cosima, Downing, James E. G., Head, Gail M., Kendall, Marion D., Mentlein, Rolf   +4 more
core   +1 more source

Rac1 deletion causes thymic atrophy.

PLoS ONE, 2011
The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood.
Lukas Hunziker, Salvador Aznar Benitah, Kristin M Braun, Kim Jensen, Katrina McNulty, Colin Butler, Elspeth Potton, Emma Nye, Richard Boyd, Geoff Laurent, Michael Glogauer, Nick A Wright, Fiona M Watt, Sam M Janes   +13 more
doaj   +1 more source

Medullary Thymic Epithelial Cell Antigen-presentation Assays

BIO-PROTOCOL, 2023
Medullary thymic epithelial cells (mTEC) are bona fide antigen-presenting cells that play a crucial role in the induction of T-cell tolerance. By their unique ability to express a broad range of tissue-restricted self-antigens, mTEC control the clonal deletion (also known as negative selection) of potentially hazardous autoreactive T cells and the ...
Borelli, Alexia, Zamit, Cloé, Irla, Magali   +2 more
openaire   +3 more sources

Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments [PDF]

, 1997
In the murine thymus, the stroma forms microenvironments that control different steps in T cell development. To study the architecture of such microenvironments and more particularly the nature of communicative signals in lympho–stromal interaction ...
Berendes, P.B. (Paul), Ewijk, W. (Willem) van, Germeraad, W.T.V. (Wilfred), Kruif, J. (John) de, Logtenberg, T. (Ton), Platenburg, P.P. (Peter Paul), Röpke, C. (Carsten)   +6 more
core   +3 more sources

Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution

Cell Reports, 2014
Summary: Age-associated thymic involution results in diminished T cell output and function in aged individuals. However, molecular mediators contributing to the decline in thymic function during early thymic involution remain largely unknown.
Sanghee Ki, Daechan Park, Hilary J. Selden, Jun Seita, Haewon Chung, Jonghwan Kim, Vishwanath R. Iyer, Lauren I.R. Ehrlich   +7 more
doaj   +1 more source

Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection [PDF]

, 2013
Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen ...
Bains, Iren, Seddon, Benedict, van Santen, Hisse M., Yates, Andrew J.   +3 more
core   +1 more source

Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells. [PDF]

PLoS ONE, 2015
Thymic epithelial cells (TECs) support T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection of developing thymocytes whereas medullary thymic epithelial cells (mTECs) facilitate the deletion of self ...
Imran S Khan, Chong Y Park, Anastasia Mavropoulos, Nikki Shariat, Joshua L Pollack, Andrea J Barczak, David J Erle, Michael T McManus, Mark S Anderson, Lukas T Jeker   +9 more
doaj   +1 more source

Coordinating Development of Medullary Thymic Epithelial Cells [PDF]

Immunity, 2008
Three papers in this issue of Immunity (Akiyama et al., 2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells.
Zhu, Mingzhao, Fu, Yang-Xin
openaire   +2 more sources