Results 81 to 90 of about 41,566 (244)
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development
Environmental Toxicology, EarlyView.ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo +10 more
wiley +1 more source
human thymocytes with high CXCR4-induced chemotaxis [PDF]
, 2005 GLUT1, the major glucose transporter in peripheral T lymphocytes, is induced upon T cell receptor activation. However, the role of GLUT1 during human thymocyte differentiation remains to be evaluated.
Sitbon, M. +13 more
core +1 more source
Tannins, novel inhibitors of the volume regulation and the volume-sensitive anion channel
European Pharmaceutical Journal, 2019 The volume-sensitive outwardly rectifying anion channel (VSOR) is a key component of volume regulation system critical for cell survival in non-isosmotic conditions.
Tsiferova N.A. +8 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2013 Developing thymocytes interact with thymic epithelial cells (TECs) through cell-cell interactions, TEC-derived secretory moieties and extracellular matrix (ECM)-mediated interactions.
Desio Aurelio Farias-de-Oliveira +5 more
doaj +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija +6 more
wiley +1 more source
Thymocytes in γδ T cell-deficient mice. [PDF]
, 2019 A) No lymphopenia in the thymus of in γδ T cell-deficient mice. Total thymocytes and thymic lymphocytes (identified by their scatter profile) were counted in the mouse strains of this study (same strains as in Fig 1).
Andrew Getahun (314428) +7 more
core +1 more source
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report
Allergy, EarlyView.ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter +19 more
wiley +1 more source
MeV infection of thymocytes in TOC. [PDF]
, 2013 TOCs from a 1 year-old child were inoculated with Chi-1 or control media at 2×10−4 pfu/cell and the MeV N protein expression in thymocytes was monitored for 6 days.
Luca A. Vricella (306425) +3 more
core +1 more source
The association of thrombocytopenia with haematological malignancy
British Journal of Haematology, EarlyView.This review article discusses the interplay of immune dysregulation, clonality, and immunosuppressive therapies in immune thrombocytopenia and how this links to the risk of misattribution versus the development of haematological malignancy. Unresolved questions and directions for future research are also discussed. Isolated thrombocytopenia is commonly
Abi Vijenthira +2 more
wiley +1 more source