Results 101 to 110 of about 41,566 (244)
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu +10 more
wiley +1 more source
IgM bound mouse apoptotic thymocytes appear disrupted. [PDF]
, 2015 Mouse thymocytes were stained with a membrane cell tracker and then rendered apoptotic by overnight culture. Thymocytes were then exposed to Balb/c plasma prior to incubation with anti-IgM, Annexin-V (AnnV) and DAPI.
Jeremy Hughes (478330) +3 more
core +1 more source
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2019 This study was done to clarify the effects of PGF2a on thymocytes in rat thymus gland, and the possibility of minimizing its effects by using fenugreek extract.
K. S. N. Al-Kaisy
doaj
Cancer Science, EarlyView.Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal +16 more
wiley +1 more source
Fas Modulation of Apoptosis during Negative Selection of Thymocytes [PDF]
, 1996 A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell ...
Jacobson, Bruce A. +7 more
core +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, EarlyView.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
Frontiers in Immunology, 2019 The thymus plays a fundamental role in establishing and maintaining central and peripheral tolerance and defects in thymic architecture or AIRE expression result in the development of autoreactive lymphocytes.
Genni Enza Marcovecchio +29 more
doaj +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The FEBS Journal, EarlyView.The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Transgenic Expression of v-Bcl-2 in Thymocytes [PDF]
, 2013 (A) Schematic illustration of the γHV68 genome, v-Bcl-2 genomic region, and transgene construct.(B) Real-time RT-PCR quantitation of v-Bcl-2 expression in transgenic thymocytes (left) and splenocytes (right).(C) Total number of thymocytes in v-Bcl-2 ...
Qiulong Huang (274980) +9 more
core +1 more source
Immunology, EarlyView.The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai +4 more
wiley +1 more source