Results 121 to 130 of about 67,295 (252)

Indirect induction of radiation lymphomas in mice. Evidence for a novel, transmissible leukemogen. [PDF]

, 1987
The transmission of a lymphomagenic agent(s) from the bone marrow of irradiated mice to thymic target cells has been demonstrated by: (a) the induction of T cell lymphomas in nonirradiated thymic grafts implanted in irradiated, Thy-l-congenic mice, (b ...
Hansteen, GA, Lieberman, M, McCune, JM, Scott, ML, Weissman, IL, White, JH   +5 more
core  

Don't Cut the Cord: Why Umbilical Cord Blood Still Deserves a Place in Transplantation

International Journal of Immunogenetics, Volume 53, Issue 3, Page 229-239, June 2026.
ABSTRACT The use of umbilical cord blood (UCB) as a stem cell source in haematopoietic stem cell transplant (HSCT) has greatly declined in recent years. It has largely been replaced by mismatched unrelated and family donors, facilitated by advances in transplant technologies, including post‐transplant cyclophosphamide to prevent graft‐versus‐host ...
Jenna Nunn, Kay Poulton, Robert Wynn
wiley   +1 more source

Suppression of ILC2 differentiation from committed T cell precursors by E protein transcription factors [PDF]

, 2019
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. Here, we demonstrate that subsets of these cells can differentiate from multipotent progenitors and committed T cell precursors in the thymus, both in ...
Adrianto, Indra, Alberola-Ila, Jose, Bajana, Sandra, Colonna, Marco, Georgescu, Constantin, Peng, Vincent, Qian, Liangyue, Sun, Xiao-Hong, Wang, Hong-Cheng, Wren, Jonathan D   +9 more
core   +1 more source

Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT The goal of achieving clinical operational tolerance in liver transplantation has sparked significant interest, driven by the desire to mitigate the long‐term adverse effects of immunosuppression. Advances in understanding the immunological mechanisms underpinning operational tolerance in liver transplantation have highlighted the central role
Emilia Knioła, Bartosz Foroncewicz, Jan Lerut, Leszek Pączek, Krzysztof Mucha   +4 more
wiley   +1 more source

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes. [PDF]

, 1988
Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here
Bluestone, JA, Cotterman, M, Cron, RQ, Houlden, BA, Matis, LA   +4 more
core  

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, Volume 61, Issue 3, Page 347-361, May 2026.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Identification of a Candidate CD5 Homologue in the Amphibian Xenopus laevis [PDF]

, 1995
We identified a novel T cell Ag in the South African clawed toad (Xenopus laevis) by a mAb designated 2B1. This Ag is present in relatively high levels on most thymocytes, approximately 65% of splenocytes, 55% of PBL, and 65% of intestinal lymphocytes ...
Cooper, Max D., Gartland, Lanier A., Göbel, Thomas W. F., Horton, John D., Jürgens, Jutta B., Pasquier, Louis D.   +5 more
core  

Thymocyte migration and emigration

Immunology Letters
Hematopoietic precursors (HPCs) entering into the thymus undergo a sequential process leading to the generation of a variety of T cell subsets. This developmental odyssey unfolds in distinct stages within the thymic cortex and medulla, shaping the landscape of T cell receptor (TCR) expression and guiding thymocytes through positive and negative ...
Qingyue Tong, Liyu Yao, Mengting Su, Yong-Guang Yang, Liguang Sun   +4 more
openaire   +2 more sources

Evaluation of Current and Novel Dosing Strategies for Anti‐Thymocyte Globulin in Adult Allogeneic Hematopoietic Stem Cell Transplantation

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Anti‐thymocyte globulin (ATG) is a polyclonal antibody used to prevent graft‐versus‐host disease in allogeneic hematopoietic stem cell transplantation. While recent studies have worked towards understanding the pharmacokinetic–pharmacodynamic relationship via population pharmacokinetic modeling, dosing remains weight‐based and largely ...
Elias Biris, Phillip R. Selby, Tahlia R. Meola, Stephanie E. Reuter   +3 more
wiley   +1 more source