Results 121 to 130 of about 41,566 (244)

Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains

Frontiers in Immunology
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) emerged about 30 years ago and continues to cause major economic losses in the pork industry.
Katerina Stepanova, Miroslav Toman, Jana Sinkorova, Simon Sinkora, Sarka Pfeiferova, Helena Kupcova Skalnikova, Helena Kupcova Skalnikova, Salim Abuhajiar, Salim Abuhajiar, Romana Moutelikova, Jiri Salat, Hana Stepanova, Katerina Nechvatalova, Lenka Leva, Petra Hermanova, Mirka Kratochvilova, Blanka Dusankova, Marek Sinkora, Vratislav Horak, Tomas Hudcovic, John E. Butler, Marek Sinkora   +21 more
doaj   +1 more source

The effect of multiprobiotic “Apibact®” on interferon production and 2',5'-oligoadenylate synthetase activity in rat thymus lymphocytes under hypoacidity evoked by omeprazole injection

Біологічні студії, 2013
The interferon (IFN) production by rat thymus lymphocytes and the activity of IFN-induced 2′,5′-oligoadenylate synthetase (2′,5′-OA-synthetase) in these cells were stu­died at hypoacidity of gastric juice evoked by omeprazole injection and also at ...
I. V. Kompanets, S. V. Pilipenko, A. G. Korotkiy, T. P. Karpovets, V. V. Nikolska, L. I. Ostapchenko, T. V. Beregova, D. S. Yankovskiy   +7 more
doaj   +1 more source

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Overexpression of LYPW inhibits TCR signaling in DP thymocytes. [PDF]

, 2014
A–B, Overexpression of LYPW causes reduced activation of Erk in thymocytes. Total thymocytes from TgLYPW or TgLYPWC227S (striped bars) or their respective non-Tg littermates (white bars) were stimulated with 20 µg/ml anti-CD3 and 10 µg/ml anti-Armenian ...
Sarah Enouz (518790), Novella Rapini (518794), Kristy Sawatzke (518795), Isaac Engel (518796), Wenbo Zhou (102293), Edoardo Fiorillo (518797), Dietmar Zehn (196610), Valeria Orrú (518791), Mitch Kronenberg (71338), Nunzio Bottini (518800), Linda A. Sherman (518798), Erik Peterson (518799), Stephanie M. Stanford (518792), Dennis J. Wu (518789), Christian J. Maine (518793)   +14 more
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The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Targeting CD162 for Life‐Threatening Cutaneous Chronic Graft‐Versus‐Host Disease: A Case Report

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Steroid‐refractory chronic cutaneous graft‐versus‐host disease (GVHD) causes substantial morbidity, prolonged hospitalization, and non‐relapse mortality after allogeneic hematopoietic cell transplantation. We report a young adult with multisystem chronic GVHD and recurrent life‐threatening inflammatory skin flares refractory to multiple ...
Alicia Lieberman, Ross McCauley, Maureen Ross, Philip McCarthy, Iming Cho, Simona Reed, Shih‐Yao Lin, Judy Chou, Shernan G. Holtan   +8 more
wiley   +1 more source

Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]

, 2006
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Freeman, Tom, Herbert, Mark, Hasegawa, Hitoshi, Willinger, Tim, Callan, Margaret F C, McMichael, Andrew J   +5 more
core  

Physical and functional association of CD45 and CD3-TCR complex on CD1 + human thymocytes. Evidence that the engagement of CD45 molecules can prevent CD1 + thymocytes from apoptosis [PDF]

, 2020
In this study the effects of CD45 engagement on CD3-TCR-driven stimulation of CD1 + human immature thymocytes have been analyzed. Simultaneous cross-linking of CD45 and CD3 antigens on highly purified CD1 + thymocytes reduced the number of cells ...

core  

ORIGINAL PAPER
The effect of monosodium glutamate on the apoptosis of rat thymocytes and Bcl-2 protein expression

Archives of Medical Science, 2006
Introduction: Monosodium glutamate (MSG) is the sodium salt of glutamic acid widely spread in modern nutrition. Numerous recent studies have shown the existance of glutamic receptors on different non-neuronal cells, which among others also include ...
Voja Pavlović, Snežana Cekić
doaj  

Understanding the Thymic Microenvironment: the Cellular and Molecular Basis of T Cell Development

Central Asian Journal of Medical Sciences, 2016
Objectives: The thymus is a primary lymphoid organ that provides specialized microenvironment for T cell development. A variety of thymic stromal cells form the thymic tissue architecture and critically regulate the development and repertoire selection ...
Takeshi Nitta
doaj   +1 more source