Results 141 to 150 of about 45,812 (254)
Frontiers in ImmunologyIntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have made it difficult to establish a causal relationship between acute infection and subsequent ...
Andrei Belean +10 more
doaj +1 more source
EFFECT OF IONIZING RADIATION ON THE PYRIDINE NUCLEOTIDES OF THYMOCYTES
, 1963 The pyridine nucleotides of thymocytes have been examined following irradiation of the cells in vivo or in vitro. NAD was found to constitute about 95% of the total oxidized pyridine nucleotides in thymocytes while the level of NADH2was found to be very ...
J. F. Scaife
core +1 more source
British Journal of Haematology, Volume 209, Issue 3, Page 1198-1207, September 2026.Early letermovir initiation (day 0) after allogeneic haematopoietic stem cell transplantation (allo‐HSCT) reduced early cytomegalovirus (CMV) infection and delayed first CMV DNAemia compared with later starts. Extending prophylaxis to 200 days virtually eliminated late CMV reactivation and improved 1‐year overall survival, with no grade ≥3 drug‐related
Shiyu Chen +4 more
wiley +1 more source
British Journal of Haematology, Volume 209, Issue 3, Page 1208-1219, September 2026.Summary Gastrointestinal acute graft‐versus‐host disease (GI aGVHD) remains a major complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), and early risk identification and intervention are essential for improving outcomes.
Gao Mengge +8 more
wiley +1 more source
Overexpression of LYPW inhibits TCR signaling in DP thymocytes.
, 2014 A–B, Overexpression of LYPW causes reduced activation of Erk in thymocytes. Total thymocytes from TgLYPW or TgLYPWC227S (striped bars) or their respective non-Tg littermates (white bars) were stimulated with 20 µg/ml anti-CD3 and 10 µg/ml anti-Armenian ...
Sarah Enouz (518790) +14 more
core +1 more source
Clinical Transplantation, Volume 40, Issue 9, September 2026.ABSTRACT Background Donor/recipient HLA molecular mismatches are predictive of kidney transplant outcomes. Their role in pancreas transplantation has not been well studied. Methods We conducted a retrospective cohort study in 281 pancreas (± kidney) transplant recipients during 2000–2018, followed for average 53.8 months.
Zakieh Zare +8 more
wiley +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, Volume 293, Issue 17, Page 5149-5169, September 2026.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
Protective and Pathogenic Antibodies to Citrullinated Antigens
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila +5 more
wiley +1 more source
Mapping the Altered Landscape of TCR Repertoire in Autoimmune Diseases
Immunological Reviews, Volume 342, Issue 1, September 2026.ABSTRACT Autoimmune diseases arise from the breakdown of immune tolerance through complex interactions between genetic predisposition, environmental exposures, and adaptive immune responses. High‐throughput T‐cell receptor (TCR) repertoire sequencing has transformed our ability to characterize these responses, providing unprecedented insights into ...
Celine Albalaa +3 more
wiley +1 more source