Results 131 to 140 of about 45,812 (254)
Advanced Science, Volume 13, Issue 49, 3 September 2026.Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao +21 more
wiley +1 more source
Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]
, 2006 The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Freeman, Tom +5 more
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Myelodysplastic Syndromes: 2026 Update on Diagnosis, Risk‐Stratification and Management
American Journal of Hematology, Volume 101, Issue 9, Page 2393-2411, September 2026.ABSTRACT Disease Overview The myelodysplastic syndromes (MDS) are a heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic therapy.
Guillermo Garcia‐Manero
wiley +1 more source
Analysis of the Role of N‐Linked Glycans on Human CD1d Molecules
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Syamdas Bandyopadhyay, Sayantan Pradhan
wiley +1 more source
Transgenic Expression of v-Bcl-2 in Thymocytes
, 2013 (A) Schematic illustration of the γHV68 genome, v-Bcl-2 genomic region, and transgene construct.(B) Real-time RT-PCR quantitation of v-Bcl-2 expression in transgenic thymocytes (left) and splenocytes (right).(C) Total number of thymocytes in v-Bcl-2 ...
Qiulong Huang (274980) +9 more
core +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang +4 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang +5 more
wiley +1 more source
Spatiotemporal immune heterogeneity and precision immunotherapy for ovarian cancer
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Graphical Highlights Spatiotemporal immune heterogeneity shapes distinct and evolving immune ecosystems in ovarian cancer. Multimodal biomarkers enable biologically informed patient stratification beyond static single‐marker approaches. Precision immunotherapy should match dominant immune barriers across lesions and treatment stages.
Xinfeng Yang +9 more
wiley +1 more source
OT-1 thymocytes overexpressing LYP-W620 show similar antigen sensitivity as non-Tg thymocytes.
, 2014 Freshly isolated OT-1 transgenic thymocytes from TgLYP (black circles), TgLYPC227S (black triangles) or control non-Tg mice (white diamonds) were co-cultured overnight together with RMA cells and the indicated doses of SIINFKL peptide (N4, left panel ...
Sarah Enouz (518790) +14 more
core +1 more source
Organ Medicine, Volume 3, Issue 3, Page 157-170, September 2026.Intestinal obstruction (IO) is an important but underexplored complication following simultaneous pancreas‐kidney transplantation (SPKT) and is associated with considerable morbidity and both clinical and economic burdens. In this single‐center cohort study, perioperative parameters, including demographic characteristics, surgical variables, and ...
Rongxin Chen +7 more
wiley +1 more source