Results 111 to 120 of about 41,566 (244)
EFFECT OF IONIZING RADIATION ON THE PYRIDINE NUCLEOTIDES OF THYMOCYTES [PDF]
, 1963 The pyridine nucleotides of thymocytes have been examined following irradiation of the cells in vivo or in vitro. NAD was found to constitute about 95% of the total oxidized pyridine nucleotides in thymocytes while the level of NADH2was found to be very ...
J. F. Scaife
core +1 more source
Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance
Immunology, EarlyView.Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos +5 more
wiley +1 more source
OT-1 thymocytes overexpressing LYP-W620 show similar antigen sensitivity as non-Tg thymocytes. [PDF]
, 2014 Freshly isolated OT-1 transgenic thymocytes from TgLYP (black circles), TgLYPC227S (black triangles) or control non-Tg mice (white diamonds) were co-cultured overnight together with RMA cells and the indicated doses of SIINFKL peptide (N4, left panel ...
Sarah Enouz (518790) +14 more
core +1 more source
Autoimmunity and Periodontitis
Journal of Periodontal Research, EarlyView.In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga +2 more
wiley +1 more source
Comparative 3‐Year Allograft Outcomes for Recipients of Kidneys From SARS‐CoV‐2 NAT‐Positive Donors
Transplant Infectious Disease, EarlyView.In this retrospective single‐center study of 220 kidney transplants from SARS‐CoV‐2 NAT+, NAT+ with COVID as cause of death (CoV‐COD) and NATneg donors, we found no significant difference in rejection or kidney pathologies at 1 year, and death, graft loss, or eGFR at 3 years by CoV‐donor status.
Christine E. Koval +5 more
wiley +1 more source
Recipient–Donor Sex Combinations and Posttransplant Infections: A Swiss Transplant Cohort Study
Transplant Infectious Disease, EarlyView.In this cohort study of 5033 patients, only the recipient sex, in particularly kidney recipients, was independently associated with an increased risk of infections, when compared to males. These findings indicate that recipient–donor sex combination does not influence short‐term solid organ transplantation outcome.
Christian T. J. Magyar +16 more
wiley +1 more source
Thymic epithelial cells provide Wnt signals to developing thymocytes [PDF]
, 2003 Interactions with thymic stromal cells are known to be critical for the development of T cells from progenitors entering the thymus, yet the molecular mechanisms of stromal cell function remain poorly understood. Accumulating evidence has highlighted the
Pongracz, J +4 more
core +1 more source
Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era
Transplant Infectious Disease, EarlyView.ABSTRACT Background Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center. Methods We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023.
Lana Hasan +6 more
wiley +1 more source