Results 91 to 100 of about 45,812 (254)

Thymocyte migration and emigration

Immunology Letters
Hematopoietic precursors (HPCs) entering into the thymus undergo a sequential process leading to the generation of a variety of T cell subsets. This developmental odyssey unfolds in distinct stages within the thymic cortex and medulla, shaping the landscape of T cell receptor (TCR) expression and guiding thymocytes through positive and negative ...
Qingyue Tong, Liyu Yao, Mengting Su, Yong-Guang Yang, Liguang Sun   +4 more
openaire   +2 more sources

Prospective Study of Targeted Busulfan–Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Genetic Rare Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Objectives Genetic rare diseases (GRDs), including chronic granulomatous disease, familial hemophagocytic lymphohistiocytosis, and congenital neutropenia, often require hematopoietic stem cell transplantation (HSCT) as the only curative option.
Bo Kyung Kim, Kyung Taek Hong, Jung Yoon Choi, Hyun Jin Park, Kyung‐Sang Yu, In‐Jin Jang, Hyoung Jin Kang   +6 more
wiley   +1 more source

Transient overexpression of CD4 enhances allelic exclusion of T-cell receptor (TCR) alpha chains and promotes positive selection of class II-restricted TCR-transgenic thymocytes. [PDF]

, 1998
CD4 contributes to antigen recognition of T cells by binding to class II MHC molecules. There is heterogeneity in expression of CD4 coreceptor among CD4+CD8+ thymocytes.
Mueller, Christoph, Munthe, Ludvig A, Bogen, Bjarne, Dembic, Zlatko, Schenck, Karl   +4 more
core   +1 more source

Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development

Frontiers in Immunology, 2019
The thymus plays a fundamental role in establishing and maintaining central and peripheral tolerance and defects in thymic architecture or AIRE expression result in the development of autoreactive lymphocytes.
Genni Enza Marcovecchio, Genni Enza Marcovecchio, Ileana Bortolomai, Ileana Bortolomai, Francesca Ferrua, Francesca Ferrua, Francesca Ferrua, Elena Fontana, Elena Fontana, Luisa Imberti, Erika Conforti, Donato Amodio, Donato Amodio, Sonia Bergante, Giulia Macchiarulo, Giulia Macchiarulo, Veronica D'Oria, Francesca Conti, Silvia Di Cesare, Georgia Fousteri, Adriano Carotti, Alessandro Giamberti, Pietro Luigi Poliani, Luigi D. Notarangelo, Caterina Cancrini, Caterina Cancrini, Anna Villa, Anna Villa, Marita Bosticardo, Marita Bosticardo   +29 more
doaj   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

N3/LacZ reporter expression in DN3 thymocytes.

, 2013
(A) Lin- DN thymocytes from N3LacZ/LacZ and N3+/+ mice were loaded with FDG and stained with anti-CD25-APC, anti-CD71-biotin, and anti-CD117-APCCy7 followed by Avidin-PECy5.
Greg Chang (344389), Paul E. Kowalski (344388), Keli Xu (344386), Philaretos C. Kousis (344387), Joanne Tan (344385), Sean E. Egan (344391), Sara Suliman (344384), Cynthia Guidos (344393)   +7 more
core   +1 more source

Fas Modulation of Apoptosis during Negative Selection of Thymocytes [PDF]

, 1996
A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell ...
Jacobson, Bruce A., Finn, Patricia W., Ju, Sherte, Perkins, David L., Wang, Yunsheng, Castro, Januario E., Listman, James A., Lopez, Peter A.   +7 more
core   +1 more source

Long‐term efficacy and safety of romiplostim plus immunosuppressive therapy as first‐line treatment in patients with aplastic anaemia: 2‐year interim analysis of observational study of two clinical trials

British Journal of Haematology, EarlyView.
Jong Wook Lee, Kohei Hosokawa, Jun Ho Jang, Naoshi Obara, Masashi Sawa, Kensuke Usuki, Gaku Oshikawa, Masahiro Kizaki, Koji Nagafuji, Ting‐An Lin, Hitoshi Hanamoto, Yeung‐Chul Mun, Toshiro Kawakita, Kazunori Imada, June‐Won Cheong, Sung‐Soo Park, Takayuki Tabayashi, Masaru Gamou, Kenta Murotani, Hirohito Yamazaki   +19 more
wiley   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Real‐world evidence on the safety and effectiveness of thrombopoietin receptor agonists in aplastic anaemia: A descriptive study using Japanese hospital administrative data

British Journal of Haematology, EarlyView.
Kayoko Mizuno, Yutaka Shimazu, Toshiki Fukasawa, Satoru Ito, Yukihiro Nishio, Mami Shimizu, Koji Kawakami   +6 more
wiley   +1 more source