Results 1 to 10 of about 20,777 (115)

Metabolic regulation of T cell development

Frontiers in Immunology, 2022
T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and posttranslational control of the intrathymic journey of T-cell precursors ...
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao   +7 more
doaj   +3 more sources

Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions

Cells, 2023
T cells expressing chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for TCR-mediated T cell activation ...
Julia Sajman, Oren Yakovian, Naamit Unger Deshet, Shaked Almog, Galit Horn, Tova Waks, Anat Globerson Levin, Eilon Sherman   +7 more
doaj   +1 more source

Search, identification, and curation of cell and gene therapy product regulations using augmented intelligent systems

Frontiers in Medicine, 2023
BackgroundManually keeping up-to-date with regulations such as directives, guidance, laws, and ordinances related to cell and gene therapy is a labor-intensive process. We used machine learning (ML) algorithms to create an augmented intelligent system to
William Schaut, Akash Shrivastav, Srikanth Ramakrishnan, Robert Bowden   +3 more
doaj   +1 more source

ATPase Thorase Deficiency Causes α-Synucleinopathy and Parkinson’s Disease-like Behavior

Cells, 2022
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases and is pathologically characterized by α-synucleinopathy, which is harmful to dopaminergic neurons.
Fei Gao, Han Zhang, Jia Yang, Menghua Cai, Qi Yang, Huaishan Wang, Yi Xu, Hui Chen, Yu Hu, Wei He, Jianmin Zhang   +10 more
doaj   +1 more source

Application of light based, non-thermal techniques to determine physico-chemical characteristics, pungency and aflatoxin levels of dried red chilli pods (Capsicum annuum)

Journal of Agriculture and Food Research, 2023
Aflatoxin contamination is a significant barrier in the international trade of major spices like chilli, aniseed, and pepper. Hence, it is crucial to develop effective aflatoxin decontamination management strategies to enhance the export potential of ...
Najma Kalathil, Nirmal Thirunavookarasu, Kavitha Lakshmipathy, D.V. Chidanand, Mahendran Radhakrishnan, N. Baskaran   +5 more
doaj   +1 more source

TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease

Cells, 2022
Background: the 18-kDa translocator protein (TSPO) is a mitochondrial outer membrane protein, and its expression tends to increase in response to inflammatory stimulation, rapidly. However, the role of TSPO in inflammation and pyroptosis is not yet clear.
Xue Zhang, Jingyi Han, Yi Xu, Menghua Cai, Fei Gao, Jiajia Han, Dongdong Wang, Yi Fu, Hui Chen, Wei He, Jianmin Zhang   +10 more
doaj   +1 more source

A doppelgänger of T cell development [PDF]

Cell Cycle, 2016
No abstract ...
Harly, Christelle, Bhandoola, Avinash
openaire   +4 more sources

Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage

Frontiers in Immunology, 2020
One of the main consequences of thymus aging is the decrease in naïve T cell output. This condition accelerates at the onset of puberty, and presents as a major clinical complication for cancer patients who require cytoablative therapy. Specifically, the
Michael Ly Hun, Kahlia Wong, Josephine Rahma Gunawan, Abdulaziz Alsharif, Kylie Quinn, Ann P. Chidgey   +5 more
doaj   +1 more source

Protein ubiquitination in T cell development

Frontiers in Immunology, 2022
As an important form of posttranslational modification, protein ubiquitination regulates a wide variety of biological processes, including different aspects of T cell development and differentiation.
Ting Zhong, Kang Lei, Xiaoxi Lin, Zhiguo Xie, Shuoming Luo, Zhiguang Zhou, Bin Zhao, Xia Li   +7 more
doaj   +1 more source

Aire and T cell development [PDF]

Current Opinion in Immunology, 2011
In the thymus, developing T cells that react against self-antigens with high affinity are deleted in the process of negative selection. An essential component of this process is the display of self-antigens, including those whose expression are usually restricted to specific tissues, to developing T cells within the thymus.
Mark S, Anderson, Maureen A, Su
openaire   +2 more sources