Results 11 to 20 of about 30,095,077 (303)

T Cell Development in Culture [PDF]

Immunity, 2002
The T cell compartment is continuously replenished by a renewable source of stem cells. In the adult, bone marrow-derived stem cells seed the thymus and initiate a developmental program that requires a series of incompletely understood signals that are normally provided by the thymus. Failure to recapitulate this process in simple in vitro cultures has
Lehar, Sophie M, Bevan, Michael J
openaire   +4 more sources

WBP1L regulates hematopoietic stem cell function and T cell development [PDF]

Frontiers in Immunology
WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood ...
Imtissal Krayem, Srdjan Grusanovic, Iris Duric, Iris Duric, Nataliia Pavliuchenko, Petr Danek, Petr Danek, Simon Borna, Jarmila Sekeresova Kralova, Tereza Skopcova, Jana Pokorna, Meritxell Alberich-Jorda, Meritxell Alberich-Jorda, Tomas Brdicka   +13 more
doaj   +2 more sources

Essential cell-intrinsic requirement for GMDS in T cell development [PDF]

Frontiers in Immunology
Fucosylation, a type of glycosylation, is the attachment of a fucose to N-glycans, O-glycans and glycolipids, and is critical for the post-translational regulation of many essential pathways.
Mehmet Yabas, Mehmet Yabas, Carla M. Roots, T. Daniel Andrews, Matt A. Field, Matt A. Field, Christopher C. Goodnow, Christopher C. Goodnow, Christopher C. Goodnow, Anselm Enders   +9 more
doaj   +2 more sources

Enhancers in T Cell development and malignant lesions [PDF]

Cell Death Discovery
Enhancers constitute a vital category of cis-regulatory elements with a Mediator complex within DNA sequences, orchestrating gene expression by activating promoters.
Tong Zhang, Lin Zou
doaj   +2 more sources

Investigating the roles of the alternative Isoforms of the preTCR alpha (pTα) chain in T cell development [PDF]

, 2010
PhDThe pre-T cell receptor (preTCR) is required for αβ T cell development and hence efficient adaptive immunity. Composed of a rearranged TCRβ chain paired with the invariant preTCR α chain (pTα), it drives immature thymocytes through the “β-selection ...
Mahtani-Patching, Juliet L
core   +4 more sources

PB1703: MODELING T-CELL DEVELOPMENT AND T-ALL INITIATION [PDF]

HemaSphere, 2023
Advaita M Dick, Erika Tsingos, Narges Aghaallaei, Julia Skokowa, Baubak Bajoghli   +4 more
doaj   +2 more sources

A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments

Frontiers in Immunology, 2020
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic ...
Christelle Harly, Christelle Harly, Christelle Harly, Devin Kenney, Yueqiang Wang, Yueqiang Wang, Yi Ding, Yongge Zhao, Parirokh Awasthi, Avinash Bhandoola   +9 more
doaj   +1 more source

Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation

Frontiers in Immunology, 2022
The LAT transmembrane adaptor is essential to transduce intracellular signals triggered by the TCR. Phosphorylation of its four C-terminal tyrosine residues (136, 175, 195, and 235 in mouse LAT) recruits several proteins resulting in the assembly of the ...
Mikel M. Arbulo-Echevarria, Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Inmaculada Vico-Barranco, Fanghui Zhang, Fanghui Zhang, Luis M. Fernandez-Aguilar, Luis M. Fernandez-Aguilar, Martyna Chotomska, Isaac Narbona-Sánchez, Isaac Narbona-Sánchez, Lichen Zhang, Bernard Malissen, Bernard Malissen, Yinming Liang, Enrique Aguado, Enrique Aguado   +16 more
doaj   +1 more source

Inter-American Development Bank Sustainability Report 2019 [PDF]

, 2020
Sustainability is a core element of the IDBs work. Long-term economic growth, and the reduction of poverty and inequality in Latin America and the Caribbean depend on development that is economically, financially, environmentally, socially, and ...
Inter-American Development Bank
core   +1 more source

T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development

Cell Reports, 2020
Summary: T cell factor 1 (Tcf1) promotes the central memory CD8+ T (TCM) cell differentiation and stemness in lymphoid tissues after systemic infections.
Jingxia Wu, Alaa Madi, Alessa Mieg, Agnes Hotz-Wagenblatt, Nina Weisshaar, Sicong Ma, Kerstin Mohr, Tilo Schlimbach, Marvin Hering, Helena Borgers, Guoliang Cui   +10 more
doaj   +1 more source