Results 21 to 30 of about 30,095,077 (303)

Asymmetric cell division safeguards memory CD8 T cell development

Cell Reports, 2023
Summary: The strength of T cell receptor (TCR) stimulation and asymmetric distribution of fate determinants are both implied to affect T cell differentiation.
Fabienne Gräbnitz, Dominique Stark, Danielle Shlesinger, Anthony Petkidis, Mariana Borsa, Alexander Yermanos, Andreas Carr, Niculò Barandun, Arne Wehling, Miroslav Balaz, Timm Schroeder, Annette Oxenius   +11 more
doaj   +1 more source

Germline T cell receptor exchange results in physiological T cell development and function

Nature Communications, 2023
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which ...
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes   +10 more
doaj   +1 more source

Neurotransmitters Modulate Intrathymic T-cell Development

Frontiers in Cell and Developmental Biology, 2021
The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues.
Carolina Francelin, Carolina Francelin, Carolina Francelin, Luciana Peixoto Veneziani, Luciana Peixoto Veneziani, Luciana Peixoto Veneziani, Alessandro dos Santos Farias, Alessandro dos Santos Farias, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Wilson Savino, Wilson Savino, Wilson Savino   +14 more
doaj   +1 more source

Multi-omic analyses in immune cell development with lessons learned from T cell development

Frontiers in Cell and Developmental Biology, 2023
Traditionally, flow cytometry has been the preferred method to characterize immune cells at the single-cell level. Flow cytometry is used in immunology mostly to measure the expression of identifying markers on the cell surface, but—with good antibodies ...
Martijn Cordes, Martijn Cordes, Karin Pike-Overzet, Erik B. Van Den Akker, Erik B. Van Den Akker, Erik B. Van Den Akker, Erik B. Van Den Akker, Frank J. T. Staal, Frank J. T. Staal, Frank J. T. Staal, Kirsten Canté-Barrett, Kirsten Canté-Barrett   +11 more
doaj   +1 more source

T-Cell Development: T-cell lineage commitment revisited [PDF]

Current Biology, 1995
Years of controversy about the lineage relationship between alpha beta and gamma delta T cells may at last have been resolved: it now appears that most T cells derive from an identical T-lineage committed precursor.
Boismenu, Richard, Havran, Wendy L.
openaire   +2 more sources

Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]

, 2008
The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg, Habu, S., Holländer, G. A., Hozumi, K., Hirano, K, Mailhos, C, Ken-ichi Hirano, Negishi, N, Saulius Zuklys, Habu, S, Zuklys, S, Yahata, T., Sonoko Habu, Mailhos, C., Georg A. Holländer, Naoko Negishi, Ando, K., Ando, K, Kiyoshi Ando, Holländer, GA, Shima, D. T., Negishi, N., Carolina Mailhos, Hozumi, K, Yahata, T, Shima, DT, Hirano, K., Katsuto Hozumi, Takashi Yahata, David T. Shima, Zuklys, S.   +30 more
core   +1 more source

T Cell Development in the Chicken

Poultry Science, 1994
This review summarizes our current view of gamma delta and alpha beta T cell development in the chicken. In it we emphasize the functional interplay between the gamma delta and alpha beta T cell subpopulations.
Chen, Chen-Lo H., Göbel, Thomas W. F., Kubota, Takayuki, Cooper, Max D.   +3 more
openaire   +3 more sources

Interleukin 7 from maternal milk crosses the intestinal barrier and modulates T-cell development in offspring [PDF]

, 2011
Background Breastfeeding protects against illnesses and death in hazardous environments, an effect partly mediated by improved immune function. One hypothesis suggests that factors within milk supplement the inadequate immune response of the offspring,
Andrew M Prentice, Prentice, Andrew M., Ngom, Pa T., Pa Tamba Ngom, Richard Aspinall, Ngom, Pa Tamba, Prentice, Andrew M, Aspinall, Richard, Andrew M. Prentice   +8 more
core   +2 more sources

Inter-American Development Bank Annual Report 2021: Financial Statements

, 2022
This report is the second of two volumes which together constitute the Inter-American Development Bank\u27s 2021 Annual Report. This report contains the management\u27s discussion and analysis of the Bank\u27s ordinary capital and financial ...
Inter-American Development Bank
core   +1 more source

Uruguay Sustainable Development Report 2021 [PDF]

, 2021
Este informe presenta una edición especial del índice de los ODS y los tableros de control para Uruguay. Uruguay se compara con los países de la OCDE utilizando un conjunto específico de indicadores de los ODS disponibles para estos países.
Inter-American Development Bank
core   +1 more source