Results 31 to 40 of about 30,095,077 (303)
MOLECULAR GENETICS OF T CELL DEVELOPMENT [PDF]
Annual Review of Immunology, 2005 ▪ Abstract T cell development is guided by a complex set of transcription factors that act recursively, in different combinations, at each of the developmental choice points from T-lineage specification to peripheral T cell specialization. This review describes the modes of action of the major T-lineage-defining transcription factors and the signal ...
Rothenberg, Ellen V., Taghon, Tom
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Metabolic regulation of regulatory T cell development and function [PDF]
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Marelli-Berg, F +7 more
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Inter-American Development Bank Group Climate Change Action Plan 2021-2025 [PDF]
, 2021 The Climate Change Action Plan describes the IDB Groups progress since 2016 to support the regions need for low-carbon and climate-resilient development finance and its plan to raise climate ambition continuously in the region.
Inter-American Development Bank
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Cytokines in T-cell development
Immunology Today, 1991 The thymus provides a unique environment for the development of T cells, supporting both precursor cell proliferation and differentiation. The control of these processes is unknown but they may be mediated by cytokines, or other soluble factors, or by interactions with specific elements of the thymic stroma.
S R, Carding, A C, Hayday, K, Bottomly
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The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity. [PDF]
, 2015 Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells.
Lau, Ching-In +18 more
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T cell receptor signaling for γδT cell development
Inflammation and Regeneration, 2019 T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are composed of different sets of somatically ...
Ryunosuke Muro +2 more
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eLife, 2022 The ability to proliferate is a common feature of most T-cell populations. However, proliferation follows different cell-cycle dynamics and is coupled to different functional outcomes according to T-cell subsets.
Jérémy Argenty +7 more
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Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
Experimental and Molecular Medicine, 2020 Immunology: The signals that turn on T cells Researchers are unravelling the molecular signaling pathways that activate T cells, white blood cells which play a central role in the immune response. Sung-Gyoo Park and colleagues at the Gwangju Institute of
Jeong-Ryul Hwang +3 more
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PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling
Frontiers in Immunology, 2020 Arginine methylation is a post-translational modification that regulates many biological processes. However, the role of arginine methylation in immune cells is not well studied.
Yukinori Tanaka +4 more
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Diacylglycerol kinases in T cell tolerance and effector function
Frontiers in Cell and Developmental Biology, 2016 Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA.
Shelley S Chen +2 more
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