Results 51 to 60 of about 48,213 (250)
The thymus and T-cell ontogeny in ballan wrasse (Labrus bergylta) is nutritionally modelled
Frontiers in Immunology, 2023 Marine fish larvae often experience high mortality unrelated to predation during early life stages, and farmed ballan wrasse (Labrus bergylta) is no exception.
Angela Etayo +6 more
doaj +1 more source
Inreased signaling intensity in CD81−/− thymocytes.
, 2012 (a) Deficiency of CD81 or CD9 does not affect T lymphocyte development and thymic cellularity. Thymocytes from B10, CD81−/− and CD9−/− mice were analyzed by multicolor flow cytometry. CD4 vs CD8 contour plots of thymocytes (top row) and lymph node cells (
Emre Deniz (115294) +6 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Is the thymus a target organ in infectious diseases?
Memorias do Instituto Oswaldo Cruz, 1992 The thymus is a central lymphoid organ, in wich T cell precursors differentiale and generate most of the so-called T cell reprtoire. Along with a variety of acute infectious diseases, we and others determined important changes in both microenvironmental ...
Wilson Savino +5 more
doaj +1 more source
Impact of in vitro HIV infection on human thymic regulatory T cell differentiation
Frontiers in Microbiology, 2023 BackgroundThe differentiation and function of immunosuppressive regulatory T cells (Tregs) is dictated by the master transcription factor FoxP3. During HIV infection, there is an increase in Treg frequencies in the peripheral blood and lymphoid tissues ...
Sharada Swaminathan +7 more
doaj +1 more source
Advanced Science, EarlyView.In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang +11 more
wiley +1 more source
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 The death receptor Fas can induce cell death through the extrinsic pathway of apoptosis in a variety of cells, including developing thymocytes. Although Fas-induced cell death has been researched and modeled extensively, most of the studies have been ...
Chang-Feng Chu +4 more
doaj +1 more source
MeV infection of thymocytes in TOC.
, 2013 TOCs from a 1 year-old child were inoculated with Chi-1 or control media at 2×10−4 pfu/cell and the MeV N protein expression in thymocytes was monitored for 6 days.
Luca A. Vricella (306425) +3 more
core +1 more source