Results 31 to 40 of about 41,566 (244)

Flow cytometry analysis of thymocytes. [PDF]

, 2013
Thymocytes were characterized by their forward (FSC) and side scattering (SSC) properties(A). Thymocytes were gated by their CD3+ expression and SSC characteristics (B) in CD3 High(gate F), CD3 low (gate G), CD3 neg (gate H). Dot plots CD3 High DP and SP
Francesca Sabbatini (359364), Monica Airoldi (364480), Ivana Marventano (364476), Daria Trabattoni (34837), Giulio Ferrario (358106), Mario Clerici (34848), Marina Saresella (364475), Fabio Zanini (364478), Andrea Gori (62770), Fabio Franzetti (359366), Alessandra Bandera (340441), Giulia Marchetti (131632), Alessandro Soria (316154)   +12 more
core   +1 more source

The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytes.

PLoS ONE, 2011
BackgroundAfter positive selection, the newly generated single positive (SP) thymocytes migrate to the thymic medulla, where they undergo negative selection to eliminate autoreactive T cells and functional maturation to acquire immune competence and ...
Fei Teng, Yubin Zhou, Rong Jin, Yu Chen, Xiaoyan Pei, Yuanfeng Liu, Jie Dong, Wei Wang, Xuewen Pang, Xiaoping Qian, Wei-Feng Chen, Yu Zhang, Qing Ge   +12 more
doaj   +1 more source

Inreased signaling intensity in CD81−/− thymocytes. [PDF]

, 2012
(a) Deficiency of CD81 or CD9 does not affect T lymphocyte development and thymic cellularity. Thymocytes from B10, CD81−/− and CD9−/− mice were analyzed by multicolor flow cytometry. CD4 vs CD8 contour plots of thymocytes (top row) and lymph node cells (
Emre Deniz (115294), Meral Ilcim Ozlu (115290), Safak Isil Cevik (115279), Nazli Keskin (115283), Uygar Halis Tazebay (115298), Serkan Belkaya (115286), Batu Erman (115303)   +6 more
core   +1 more source

Cytosolic sequestration of Prep1 influences early stages of T cell development.

PLoS ONE, 2008
ObjectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic ...
Dmitry Penkov, Martina Palazzolo, Anna Mondino, Francesco Blasi   +3 more
doaj   +1 more source

Susceptibility of different subsets of immature thymocytes to apoptosis [PDF]

, 1997
In the present study the susceptibility of different subsets of immature rat thymocytes to undergo apoptosis was examined. Unfractionated rat thymocytes were negatively enriched into immature double positive (CD4+CD8+), immature single positive (CD4−CD8 ...
Gerald M Cohen, Snowden, Roger, Roger Snowden, Sten Orrenius, Orrenius, Sten, Chow, Sek C, Sek C Chow, Cohen, Gerald M   +7 more
core   +1 more source

Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility

iScience, 2018
Summary: Extracellular signal-regulated kinase (ERK) plays critical roles in T cell development in the thymus. Nevertheless, the dynamics of ERK activity and the role of ERK in regulating thymocyte motility remain largely unknown due to technical ...
Yoshinobu Konishi, Kenta Terai, Yasuhide Furuta, Hiroshi Kiyonari, Takaya Abe, Yoshihiro Ueda, Tatsuo Kinashi, Yoko Hamazaki, Akifumi Takaori-Kondo, Michiyuki Matsuda   +9 more
doaj   +1 more source

ADAM8^−/− thymi have increased numbers of thymocytes. [PDF]

, 2013
Numbers of (A) early thymic progenitors (ETP: DN1 ckit+), (B) DN thymocytes, (C) DP thymocytes, (D) CD4 and CD8 thymocytes, (E) semi and late mature CD4 thymocytes and (F) semi and late mature CD8 thymocytes in wt and ADAM8−/− thymi.
Klaus Gossens (376981), Silvia Naus (361705), Georg A. Holländer (79665), Hermann J. Ziltener (361706)   +3 more
core   +1 more source

Chemorepulsion and thymocyte emigration [PDF]

Journal of Clinical Investigation, 2002
The possibility that chemorepulsion, or cell migration away from a stimulus, plays a role in the immune system is exciting from both clinical and cell-biological viewpoints. For the clinician, what could be a more satisfying way to treat a cell-mediated immune disease than local application of a chemorepellent?
openaire   +2 more sources

Early growth response gene-2 (Egr-2) regulates the development of B and T cells [PDF]

, 2011
The study was supported by Arthritis Research UK. Copyright @ 2011 Li et al.BACKGROUND: Understanding of how transcription factors are involved in lymphocyte development still remains a challenge.
Miao, T, Wang Ping, Zhu, B, Zhu Bo, Alistair L. J. Symonds, Symonds, A L J, Mengya Liu, Liu, M, Liu, MY, Raymond, MV, Wang, P, Liu Mengya, Symonds, ALJ, Suling Li, Miao Tizong, Li Suling, Alistair L J Symonds, Li, SL, Tizong Miao, Ping Wang, Symonds Alistair L. J., Meera V. Raymond, Meera V Raymond, Raymond, M, Raymond Meera V., Miao, TZ, Li, S, Bo Zhu   +27 more
core   +1 more source

Metabolic regulation of T cell development

Frontiers in Immunology, 2022
T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and posttranslational control of the intrathymic journey of T-cell precursors ...
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao   +7 more
doaj   +1 more source