eLife, 2019 CD4 and CD8 T cells are vital components of the immune system. We found that histone deacetylase 3 (HDAC3) is critical for the development of CD4 T cells, as HDAC3-deficient DP thymocytes generate only CD8SP thymocytes in mice.
Rachael Laura Philips +8 more
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PLoS ONE, 2011 BackgroundAfter positive selection, the newly generated single positive (SP) thymocytes migrate to the thymic medulla, where they undergo negative selection to eliminate autoreactive T cells and functional maturation to acquire immune competence and ...
Fei Teng +12 more
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A novel activity on thymocytes cells exerted by the rattlesnake (Crotalus durissus cumanensis) venom
Biomédica: revista del Instituto Nacional de Salud, 2021 Introduction: The thymus is active mainly during the neonatal and pre-adolescent periods. Objective: To test naïve thymocytes proliferation and monocytes stimulation. Materials and methods: We collected fresh thymus tissue from neonate mice after surgery.
María M. Pulido-Méndez +2 more
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Cytosolic sequestration of Prep1 influences early stages of T cell development.
PLoS ONE, 2008 ObjectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic ...
Dmitry Penkov +3 more
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Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]
, 2017 Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling +4 more
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Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]
, 2008 The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie +8 more
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iScience, 2018 Summary: Extracellular signal-regulated kinase (ERK) plays critical roles in T cell development in the thymus. Nevertheless, the dynamics of ERK activity and the role of ERK in regulating thymocyte motility remain largely unknown due to technical ...
Yoshinobu Konishi +9 more
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T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development. [PDF]
PLoS ONE, 2014 Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer.
Archna Sharma +2 more
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Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection [PDF]
, 2013 Conventional and regulatory T cells develop in the thymus where they are exposed to samples of self-peptide MHC (pMHC) ligands. This probabilistic process selects for cells within a range of responsiveness that allows the detection of foreign antigen ...
Bains, Iren +3 more
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HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression
Retrovirology, 2011 Background Thymic function is altered in HIV infection and characterized by dysregulation of the thymic epithelial network, reduced thymic output and ultimately an impaired naïve T-cell pool.
Young Charlene D, Angel Jonathan B
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