Results 31 to 40 of about 45,812 (254)
Cytosolic sequestration of Prep1 influences early stages of T cell development.
PLoS ONE, 2008 ObjectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic ...
Dmitry Penkov +3 more
doaj +1 more source
Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes [PDF]
, 1990 A family of homologous serine esterases designated granzyme A-H and the pore-forming protein perforin are present in cytoplasmic granules of mature peripheral cytolytic T lymphocytes and natural killer cells.
Macdonald, H. Robson +5 more
core +2 more sources
iScience, 2018 Summary: Extracellular signal-regulated kinase (ERK) plays critical roles in T cell development in the thymus. Nevertheless, the dynamics of ERK activity and the role of ERK in regulating thymocyte motility remain largely unknown due to technical ...
Yoshinobu Konishi +9 more
doaj +1 more source
Chemorepulsion and thymocyte emigration [PDF]
Journal of Clinical Investigation, 2002 The possibility that chemorepulsion, or cell migration away from a stimulus, plays a role in the immune system is exciting from both clinical and cell-biological viewpoints. For the clinician, what could be a more satisfying way to treat a cell-mediated immune disease than local application of a chemorepellent?
openaire +2 more sources
Susceptibility of different subsets of immature thymocytes to apoptosis [PDF]
, 1997 In the present study the susceptibility of different subsets of immature rat thymocytes to undergo apoptosis was examined. Unfractionated rat thymocytes were negatively enriched into immature double positive (CD4+CD8+), immature single positive (CD4−CD8 ...
Gerald M Cohen +7 more
core +1 more source
Metabolic regulation of T cell development
Frontiers in Immunology, 2022 T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and posttranslational control of the intrathymic journey of T-cell precursors ...
Mengdi Zhang +7 more
doaj +1 more source
HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression
Retrovirology, 2011 Background Thymic function is altered in HIV infection and characterized by dysregulation of the thymic epithelial network, reduced thymic output and ultimately an impaired naïve T-cell pool.
Young Charlene D, Angel Jonathan B
doaj +1 more source
Neurotransmitters Modulate Intrathymic T-cell Development
Frontiers in Cell and Developmental Biology, 2021 The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues.
Carolina Francelin +14 more
doaj +1 more source
Aldehydes participation in oxidative stress in rat thymocytes in vitro [PDF]
The Ukrainian Biochemical Journal, 2014 A variety of lipid radicals are formed under oxidative stress development. The further oxidation of these radicals leads to formation of numerous aldehydes.
K. О. Tokarchuk, О. V. Zaitseva
doaj +1 more source
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection
eLife, 2021 Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu +13 more
doaj +1 more source