Results 31 to 40 of about 48,213 (250)

A novel activity on thymocytes cells exerted by the rattlesnake (Crotalus durissus cumanensis) venom

Biomédica: revista del Instituto Nacional de Salud, 2021
Introduction: The thymus is active mainly during the neonatal and pre-adolescent periods. Objective: To test naïve thymocytes proliferation and monocytes stimulation. Materials and methods: We collected fresh thymus tissue from neonate mice after surgery.
María M. Pulido-Méndez, Elvia Azuaje, Alexis Rodríguez-Acosta   +2 more
doaj   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance. [PDF]

Immunology
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Passos GA, Faça VM, Donadi EA, Masson AP, Coletto CC, Roza GR.   +5 more
europepmc   +2 more sources

Cytosolic sequestration of Prep1 influences early stages of T cell development.

PLoS ONE, 2008
ObjectivePrep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus. We previously reported reduced Pbx2 expression and defective thymocyte maturation in Prep1 hypomorphic ...
Dmitry Penkov, Martina Palazzolo, Anna Mondino, Francesco Blasi   +3 more
doaj   +1 more source

Live-Cell FRET Imaging Reveals a Role of Extracellular Signal-Regulated Kinase Activity Dynamics in Thymocyte Motility

iScience, 2018
Summary: Extracellular signal-regulated kinase (ERK) plays critical roles in T cell development in the thymus. Nevertheless, the dynamics of ERK activity and the role of ERK in regulating thymocyte motility remain largely unknown due to technical ...
Yoshinobu Konishi, Kenta Terai, Yasuhide Furuta, Hiroshi Kiyonari, Takaya Abe, Yoshihiro Ueda, Tatsuo Kinashi, Yoko Hamazaki, Akifumi Takaori-Kondo, Michiyuki Matsuda   +9 more
doaj   +1 more source

Chemorepulsion and thymocyte emigration [PDF]

Journal of Clinical Investigation, 2002
The possibility that chemorepulsion, or cell migration away from a stimulus, plays a role in the immune system is exciting from both clinical and cell-biological viewpoints. For the clinician, what could be a more satisfying way to treat a cell-mediated immune disease than local application of a chemorepellent?
openaire   +2 more sources

RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation [PDF]

European Journal of Immunology, 2002
Thymocyte maturation is controlled by successive developmental checkpoints connected to the acquisition of a functional T cell receptor (TCR). During thymocyte selection, engagement of the TCR regulates the fine balance between death and survival signals.
Sandrine, Guerin, Marie-Laurence, Baron, René, Valero, Magali, Herrant, Patrick, Auberger, Philippe, Naquet   +5 more
openaire   +2 more sources

HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression

Retrovirology, 2011
Background Thymic function is altered in HIV infection and characterized by dysregulation of the thymic epithelial network, reduced thymic output and ultimately an impaired naïve T-cell pool.
Young Charlene D, Angel Jonathan B
doaj   +1 more source

Metabolic regulation of T cell development

Frontiers in Immunology, 2022
T cell development in the thymus is tightly controlled by complex regulatory mechanisms at multiple checkpoints. Currently, many studies have focused on the transcriptional and posttranslational control of the intrathymic journey of T-cell precursors ...
Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao   +7 more
doaj   +1 more source

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Lei, Y., Jeker, L. T., Georg A. Holländer, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Nagasawa, T., Izumi Ohigashi, Ripen, A. M., Ohigashi, I., Takashi Nagasawa, Malefyt Rde, W., Adiratna Mat Ripen, Nitta, Takeshi, Ripen, Adiratna Mat, Bösl, Michael R., Lei, Yu, de Waal Malefyt, Rene, Jeker, Lukas T., Ishimaru, Naozumi, Hayashi, Yoshio, Takahama, Yousuke, Ohigashi, Izumi, Nagasawa, Takashi, Holländer, Georg A.   +35 more
core   +1 more source

Neurotransmitters Modulate Intrathymic T-cell Development

Frontiers in Cell and Developmental Biology, 2021
The existence of a crosstalk between the nervous and immune systems is well established. Neurotransmitters can be produced by immune cells, whereas cytokines can be secreted by cells of nervous tissues.
Carolina Francelin, Carolina Francelin, Carolina Francelin, Luciana Peixoto Veneziani, Luciana Peixoto Veneziani, Luciana Peixoto Veneziani, Alessandro dos Santos Farias, Alessandro dos Santos Farias, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Daniella Arêas Mendes-da-Cruz, Wilson Savino, Wilson Savino, Wilson Savino   +14 more
doaj   +1 more source