Results 21 to 30 of about 67,295 (252)
Thymocytes can tolerize thymocytes by clonal deletion in vitro [PDF]
International Immunology, 1992 Clonal deletion of thymocytes bearing TCR for self antigens is one major mechanism of T cell tolerance induction. Peptide antigen-induced deletion of thymocytes from alpha beta TCR transgenic mice has been studied using single cell suspension cultures.
Pircher, Hanspeter +3 more
openaire +4 more sources
Journal of Traditional Chinese Medical Sciences, 2018 Objective: To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.), a Chinese medicinal herb used in the treatment of rheumatoid arthritis for centuries in ...
Huifang Deng +8 more
doaj +1 more source
The sensitivity of cells with the various level of NAD(P)H:quinone oxidoreductase 1 to cytotoxic action of quinonimines and α-тоcopherol synthetic derivatives [PDF]
The Ukrainian Biochemical Journal, 2015 The effects of α-tocopherol with shortened to 6 carbon atoms side chain (α-Toc-C6), α-tocopherol succinate (α-TS) and quinonimine 2,6-dichlorophenolindophenol (DCPIP) on DT-diaphorase activity and viability of rat thymocytes, splenocytes and hepatocytes ...
G. V. Petrova, А. V. Parshykov
doaj +1 more source
Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes. [PDF]
, 1995 Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70.
Gelfand, EW +4 more
core +2 more sources
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]
, 2020 The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina +10 more
core +3 more sources
Cell Reports, 2018 Summary: T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly distinct
Anne Gegonne +8 more
doaj +1 more source
Notch signaling during human T cell development [PDF]
, 2012 Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy +97 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2008 Both oxidative stress and endoplasmic reticulum (ER) stress have been implicated in carcinogenesis. It is well documented that cells deficient in the ataxia-telangiectasia mutated (ATM) gene undergo oxidative stress, which is critically involved in ...
Mingshan Yan +6 more
doaj +1 more source
Calcium Signaling Is Impaired in PTEN-Deficient T Cell Acute Lymphoblastic Leukemia
Frontiers in Immunology, 2022 PTEN (Phosphatase and TENsin homolog) is a well-known tumor suppressor involved in numerous types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL). In human, loss-of-function mutations of PTEN are correlated to mature T-ALL expressing a T-
Saran Pankaew +9 more
doaj +1 more source
Murine terminal deoxynucleotidyl transferase: cellular distribution and response to cortisone [PDF]
, 1975 The mouse thymus contains two forms of terminal deoxynucleotidyl transferase (TdT) which are distinguishable by the salt concentration necessary to elute them from a phosphocellulose column, by their distrubtion among the thymocyte subpopulations, and by
Baltimore, David +3 more
core +1 more source