Results 131 to 140 of about 307,196 (302)

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Exploring antigenic variation in autoimmune endocrinopathy

Frontiers in Immunology
Autoimmune disorders develop owing to a misdirected immune response against self-antigen. Genetic studies have revealed that numerous variants in genes encoding immune system proteins are associated with the development of autoimmunity.
Maria Mavridou, Simon H. Pearce, Simon H. Pearce   +2 more
doaj   +1 more source

Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages. [PDF]

, 2015
To elucidate the transcriptional 'landscape' that regulates human lymphoid commitment during postnatal life, we used RNA sequencing to assemble the long non-coding transcriptome across human bone marrow and thymic progenitor cells spanning the earliest ...
Casero, David, Crooks, Gay M, Ha, Vi Luan, Luong, Annie, Parekh, Chintan, Sandoval, Salemiz, Scholes, Jessica, Seet, Christopher S, Zhu, Yuhua   +8 more
core  

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

A comprehensive checklist of Mediterranean wild edible plants: Diversity, traditional uses, and knowledge gaps

PLANTS, PEOPLE, PLANET, EarlyView.
The use of wild edible plants and the traditional knowledge associated with them are rapidly disappearing across the Mediterranean, with serious consequences for biodiversity, cultural heritage, and regional food security. This study compiles and organizes fragmented information to create the first comprehensive catalogue of these plants across the ...
Benedetta Gori, Tiziana Cossu, Hicham El Zein, Udayangani Liu, Tiziana Ulian, Gianluigi Bacchetta   +5 more
wiley   +1 more source

Ethnobotanical insights into the medicinal and food uses of Lamiaceae in the Mediterranean region: A systematic review and meta‐analysis

PLANTS, PEOPLE, PLANET, EarlyView.
For generations, Mediterranean communities have used Lamiaceae or Labiatae plants like rosemary, thyme or mint to care for their health and to enrich their food. By bringing together dispersed knowledge from across the Mediterranean region, our review revealed the continuing relevance of Lamiaceae while also compiling past uses that may hold future ...
Fuencisla Cáceres, Joan Vallès, Teresa Garnatje, Airy Gras   +3 more
wiley   +1 more source

The phytosociology of calcareous grasslands in the British Isles. [PDF]

, 1968
The thesis attempts a broad overall survey and classification according to the Zurich-Montpellier system ofplant sociology, of limestone grassland vegetation in the British Isles The classification is based on some 535 grassland Aufnahmen and 75 ...
Shimwell, David William
core   +1 more source

How does leaf age affect performance? A comparative study of essential oils from young and mature Eucalyptus globulus leaves in crop protection

Pest Management Science, EarlyView.
Leaf age influences metabolomic profiling but not bioactivity of Eucalyptus globulus essential oils. Leaf age affects volatile levels of young and adult E. globulus oils, but not their bioactivity. Young leaf essential oil had higher contents of α‐ and β‐pinene. AEEO had higher levels of 1,8‐cineole and trans‐pinocarveol.
Mafalda Pinto, Cristiano Soares, Ana Cristina Figueiredo, Joana Neto, Pedro A S Sousa, Ana A R M Aguiar, Michele Narduzzi, Chiara Antonelli, Anna Maria Vettraino, Tatiana Andreani, Fernando Tavares, Fernanda Fidalgo   +11 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan, Candace L. Doepker, Gregory P. Brorby   +2 more
wiley   +1 more source