Results 191 to 200 of about 208,657 (313)

The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer

Cancer Science, EarlyView.
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley   +1 more source

Developmental Dynamics of Bioactive Compound Accumulation During Vegetative Growth in Thymus daenensis Čelak. [PDF]

Chem Biodivers
Bakhshy E, Zarinkamar F, Nazari M.
europepmc   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

Expression of Rate-Limiting Enzymes of Melatonin Synthesis in Several Extrapineal Organs During Pregnancy in Ewes. [PDF]

Biomolecules
Xu Y, Hou H, Yang Y, Gao D, Zhang L, Yang L.   +5 more
europepmc   +1 more source

Hematopoietic Antigen Presenting Cells Fine-Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells. [PDF]

Eur J Immunol
Wang Y, Lam TT, Ochiai S, Larson AR, Matthews DB, McWilliam HEG, Kaisho T, Lahoud MH, Villadangos JA, Diehl GE, Ronchese F, Pellicci DG, Chong MMW.   +12 more
europepmc   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment. [PDF]

Front Immunol
Fraszczak J, Obwegs D, Arman K, Muralt T, Thurairajah B, Mallet Gauthier È, King IL, Melichar HJ, Sagar, Möröy T.   +9 more
europepmc   +1 more source

Diagnostic Options in Graves' or Non‐Graves' Thyrotoxicosis: A Review for Clinical Practice

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Distinguishing Graves' disease (GD) from the other causes of thyrotoxicosis is essential for appropriate management. The clinical phenotype of GD has evolved over time and is currently more heterogenous and milder than in the past. Consequently, the differential diagnosis of thyrotoxicosis is often challenging.
Lorenzo Scappaticcio, Pierpaolo Trimboli, Paola Caruso, Chiara Porcellini, Daniela Forestiere, Maria Ida Maiorino, Katherine Esposito, Giuseppe Bellastella   +7 more
wiley   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Robotic-Assisted Extended Thymus Carcinoma Resection With Unilateral Total Pleurectomy and Hyperthermic Intrathoracic Chemotherapy (HITOC). [PDF]

Case Rep Surg
Kröplin MA, Keller P, Eckstein N, Menghesha H, Feodorovici P, Buermann J, Schmidt J, Zalepugas D.   +7 more
europepmc   +1 more source