Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
IL-7R-Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation. [PDF]
Liao Y +21 more
europepmc +1 more source
From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger +3 more
wiley +1 more source
Optimized detection of caspase-6 activation in a murine inflammation model to inform neurodegenerative disease therapies. [PDF]
Sagarbarria I +6 more
europepmc +1 more source
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 260-263, March 2025.
Celeste M. Boesjes +7 more
wiley +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
Integrative transcriptomic and proteomic profiling reveals altered thymocyte development and microenvironment remodeling during natural thymic atrophy. [PDF]
Lin W +6 more
europepmc +1 more source
We compiled the first checklist of wild bees in Doñana Protected Area, documenting 385 species, including three vulnerable and one endangered species listed in the Red List. Bee species exhibit diverse floral preferences, highlighting the need to incorporate plant–pollinator interactions and the role of plants in conservation and management strategies ...
Francisco P. Molina +3 more
wiley +1 more source
Modulatory Effect of the Alfalfa Polysaccharide Fraction II on Cyclophosphamide-Induced Immunosuppression in Mice. [PDF]
Li F +7 more
europepmc +1 more source
Fluoride‐Free Mouthwashes Available Over‐The‐Counter in the US‐An Overview
ABSTRACT Purpose Fluoride‐free mouthwashes (FFM) are commonly used by patients for a variety of cosmetic and/or therapeutic reasons. The purpose of this study was to investigate the composition and purposes of FFM available over‐the‐counter in the US.
Astrid C. Valdivia‐Tapia +3 more
wiley +1 more source

