Results 261 to 270 of about 343,899 (350)

Mitochondrial control of ciliary gene expression and structure in striatal neurons

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen   +5 more
wiley   +1 more source

Preclinical Evaluation of the Safety of the Dedicated Gel for Gel Immersion Endoscopy With Gastrointestinal Perforation and Peritoneal Leakage

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Gel immersion endoscopic mucosal resection or endoscopic submucosal dissection has been developed as an alternative to saline immersion therapeutic endoscopy. However, in cases of gastrointestinal perforation, gel may leak from the lumen into the peritoneal cavity, and the safety of such events remains unclarified.
Atsushi Ohata   +5 more
wiley   +1 more source

A Thymus-Independent Artificial Organoid System Supports Complete Thymopoiesis from Rhesus Macaque-Derived Hematopoietic Stem and Progenitor Cells. [PDF]

open access: yesBiomedicines
Wilde C   +8 more
europepmc   +1 more source

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

open access: yesJOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump   +8 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang   +7 more
wiley   +1 more source

A Novel Cell‐Penetrating Lipopeptide for DNA Binding, Self‐Assembly, and Delivery Into HeLa and Pluripotent Stem Cells

open access: yesJournal of Peptide Science, Volume 32, Issue 3, March 2026.
A lipopeptide is designed that contains an epitope from simian virus T‐antigen (SV40T, PKKKRKV) conjugated to an N‐terminal palmitoyl (C16‐) moiety, which acts as a cell‐penetrating lipopeptide, with additional aggregation propensity conferred by the lipid chain. The lipopeptide enables DNA delivery into the cytoplasm and nucleus.
Lucas R. de Mello   +6 more
wiley   +1 more source

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