Results 61 to 70 of about 262,172 (291)

New Morphological Ideas of the Participation of the Thymus Gland in the Processes of Immunity

, 2023
The thymus (thymus gland) is the central organ of T-lymphocytopoesis, the formation of T-lymphocyte progenitor cells and a number of thymic hormones takes place in it.
Sh .R.Davronova
core  

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Comparative sonographic measurement of the fetal thymus size in singleton and twin pregnancies

Journal of Perinatal Medicine
The aim of this study was to compare the size of the thymus gland of healthy fetuses in twin and singleton pregnancies using the thymic-thoracic ratio (TTR). As a second objective, the TTR difference between monochorionic and dichorionic twin thymus size
Kuper Anna-Lena, Schmitz Ralf, Oelmeier Kathrin, De Santis Chiara, Willy Daniela, Braun Janina, Kerschke Laura, Möllers Mareike   +7 more
doaj   +1 more source

THEME: THE THYMUS GLAND AS AN ORGAN OF THE ENDOCRINE SYSTEM. PHYSIOLOGY OF THE THYMUS

, 2021
Views on the hormonal role of the thymus gland in the body have undergone significant changes depending on the level of our knowledge about its structure and functions.
Ismatova Iroda Farkhadovna, Burkhanova Dilovar Sadridinovna   +1 more
core  

Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]

, 1999
Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Downing, James E. G., Brucker, Cosima, Mentlein, Rolf, Kendall, Marion D., Head, Gail M.   +4 more
core   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

MAPA: A Semantic Network Framework for Functional Module Discovery and Interpretation in Multi‐Omics Data

Advanced Science, EarlyView.
MAPA transforms complex multi‐omics data into biologically coherent functional modules by integrating pathway information with molecular interaction networks. Retrieval‐augmented large language models then generate structured, literature‐informed interpretations.
Yifei Ge, Feifan Zhang, Yijiang Liu, Chao Jiang, Peng Gao, Nguan Soon Tan, Sai Zhang, Yuchen Shen, Qianyi Zhou, Xin Zhou, Xiao Wang, Fangqing Zhao, Chuchu Wang, Xiaotao Shen   +13 more
wiley   +1 more source

Histopathological Changes of Two Antigens Prepared from Methicillin-Resistant Staphylococcus aureus in Rats

مجلة علوم ذي قار, 2020
The aim of the present study was to determine the effect of two prepared antigens fromMethicillin-resistantStaphylococcus aureus (MRSA), whichincluded crude alpha toxin (Hla) and heat inactivate bacterial suspension (HIBS)  in rats through the ...
Zainab Dakhil Degaim, Wafaa Sadoon Shani, Saad Salman Hamim   +2 more
doaj  

Thymus gland and thymic dysfunctions in children [PDF]

Romanian Journal of Pediatrics
The thymus is the organ that has gained significant awareness in the last two centuries, being considered the main donor of cells for the lymphatic system, much like the bone marrow is the donor of cells for the cardiovascular system.
Tamara Turcanu, Elena Dolapciu
doaj   +1 more source