Results 111 to 120 of about 136,384 (208)

Arrhythmias associated with immune checkpoint inhibitor therapy—A clinical perspective

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are associated with a growing spectrum of cardiovascular immune‐related adverse events. Among these, arrhythmias represent a rare yet potentially life‐threatening complication. ICI‐induced arrhythmias encompass a wide clinical spectrum, including atrial arrhythmias, conduction ...
Dong Wang, Melanie Ricke‐Hoch, David Duncker, Johann Bauersachs, Dominik Berliner   +4 more
wiley   +1 more source

Evaluation of clinical, morphological and pathohistological characteristics of thymomas: Our ten year experience [PDF]

Archive of Oncology, 2017
Background. Thymomas are rare neoplasms arising from tissue elements of the thymus. The objective of the study was to analyse clinical characteristics of patients with thymoma, as well as morphological and patohistological features of neoplasms. Methods:
Lovrenski Aleksandra, Tegeltija Dragana, Jeličić Ivana, Bijelović Milorad, Đurić Dejan, Panjković Milana   +5 more
doaj  

Inflammation and Thymus Ageing

, 2017
The thymus is primarily responsible for T cell production. However, it begins to recede in size and function, from early in life. This decreased generation of naive T cells during normal thymus ageing, or linked with pathology (i.e. chronic inflammation),
A. Alsharif, Ann P. Chidgey, Lepletier, A, Chidgey, Ann P, A. Lepletier, Alsharif, A   +5 more
core   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

NEDD4 Promotes Hepatocellular Carcinoma Progression Through Ubiquitin‐Dependent Degradation of EPHB6

Cancer Science, EarlyView.
NEDD4 drives K48‐linked polyubiquitination and proteasomal degradation of EPHB6, activating TGF‐beta SMAD2/3 signaling and upregulating EMT markers to promote tumor progression. ABSTRACT Neural precursor cell expressed developmentally down‐regulated 4 (NEDD4) has been implicated in the progression of various human malignancies, including hepatocellular
Guowei Zhang, Mengxuan Ji, Zhiyi Liu, Jiawei Xu, Qinghe Hu, Xue Zhang, Jie Qiu, Kai Wu, Bin Zhang, Yi He, Hengliang Shi   +10 more
wiley   +1 more source

Brain metastases from a thymoma: Case report for a rare secondary localization

Radiology Case Reports
Thymomas are benign epithelial neoplasms originating from the thymus gland and are among the most common primary mediastinal tumors. Malignancy is typically determined by evidence of pathological invasion beyond the capsule, with local invasion being the
Ghassen Gader, Skander Guediche, Ines Moussa, Sinda Ben Zekri, Mohamed Badri, Ahmed Harbaoui, Ihsèn Zammel   +6 more
doaj   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source