Results 131 to 140 of about 136,384 (208)

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

open access: yesAdvanced Science, Volume 13, Issue 61, 3 November 2026.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng   +13 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3902-3913, November 2026.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub   +3 more
wiley   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

open access: yes, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Travis, W.   +7 more
core  

Adaptive Immunity in Marsupials

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 9, Page 913-932, November 2026.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol   +2 more
wiley   +1 more source

Phytochemical characteristics and nutraceutical properties of Thymus sp.

open access: yes
openQuesto lavoro si propone di analizzare le principali proprietà biologiche e terapeutiche del genere Thymus, appartenente alla famiglia delle Lamiaceae. Il Thymus, con circa 215 specie, è noto per la sua ricchezza di composti bioattivi come timolo e
BALBONI, GRETA MARIA
core  

Complete Surgical Resection of Rare Solitary Anterior Mediastinal Metastasis From Ovarian Clear Cell Carcinoma

open access: yesRespirology Case Reports, Volume 14, Issue 11, November 2026.
Here, we report an extremely rare case of a solitary anterior mediastinal metastasis from ovarian clear cell carcinoma. The lesion was successfully managed with complete R0 surgical resection via median sternotomy. In patients with a history of ovarian clear cell carcinoma, aggressive surgical intervention should be considered for isolated thoracic ...
Teruhisa Chiba   +6 more
wiley   +1 more source

Nonlinear Aging of the Human TCR Repertoire Is Influenced by Sex, CMV, and Cancer

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
Aging is associated with a nonlinear decline in peripheral blood TCR repertoire diversity, with an accelerated decline after ~50 years, while sex, CMV infection, and cancer further shape TCR diversity. The age‐associated decrease in diversity was accompanied by shifts in clonal and T cell subtype composition.
Naja Lange   +9 more
wiley   +1 more source

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

open access: yesAging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

Limiting dilution analysis of alloantigen-reactive T lymphocytes. VI. Ontogeny of cytolytic T lymphocyte precursors in the thymus

open access: yes, 1981
The ontogeny of development of precursors of cytolytic T lymphocytes (CTL-P) in the murine thymus has been investigated. Fetal or newborn thymocytes harvested from C57BL/6 mice were cultured with irradiated allogeneic (DBA/2) spleen cells in limiting ...
MacDonald, H. R.   +2 more
core   +1 more source

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