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The structure of human thyroglobulin [PDF]

open access: yesNature, 2020
Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in ...
Francesca Coscia   +2 more
exaly   +11 more sources

Is thyroglobulin a reliable biomarker of differentiated thyroid cancer in patients treated by lobectomy? A systematic review and meta-analysis

open access: yesClinical Chemistry and Laboratory Medicine, 2022
Objectives The prognostic role of thyroglobulin in predicting recurrence in differentiated thyroid cancer (DTC) patients treated by lobectomy is controversial.
Luca Giovanella
exaly   +2 more sources

Effect of Thyroglobulin Autoantibodies on the Metabolic Clearance of Serum Thyroglobulin [PDF]

open access: yesThyroid, 2018
In order to establish whether thyroglobulin autoantibodies (TgAb) influence the metabolic clearance of thyroglobulin (Tg) in humans, serum Tg and TgAb were correlated shortly after radioiodine (Samples were collected from 30 consecutive patients undergoingTg was detectable in all patients at day 0.
Latrofa F   +7 more
openaire   +5 more sources

Urinary Exosomal Thyroglobulin in Thyroid Cancer Patients With Post-ablative Therapy: A New Biomarker in Thyroid Cancer

open access: yesFrontiers in Endocrinology, 2020
Background: Most patients with thyroid cancer typically receive thyroidectomy with ablative radioactive iodine therapy. Such patients were followed with thyroid ultrasonography and serial serum thyroglobulin evaluation. Exosomes are nanovesicles secreted
Chih-yuan Wang   +2 more
exaly   +2 more sources

The Properties of Thyroglobulin

open access: hybridJournal of Biological Chemistry, 1966
Abstract All the disulfide bonds of thyroglobulin have been completely reduced with β-mercaptoethanol in urea or guanidine at alkaline pH. The molecular properties of reduced carboxymethylated thyroglobulin have been investigated in aqueous solution by sedimentation velocity, viscosity, difference spectra, optical rotation, polarization of fluorescence,
B. de Crombrugghe   +2 more
openalex   +4 more sources

Subunit Heterogeneity of Thyroglobulin [PDF]

open access: hybridJournal of Biological Chemistry, 1973
The subunit structure of thyroglobulin has been investigated by gel filtration and polyacrylamide electrophoresis in sodium dodecyl sulfate (SDS) of the native and the S-carboxymethylated proteins. When the thyroglobulins from several species (calf, sheep, pig, man, rat, and guinea pig) were examined by polyacrylamide electrophoresis in SDS in the ...
Mary Jane Spiro
openalex   +3 more sources

Thyroglobulin measurement in fine‐needle aspiration biopsy of metastatic lymph nodes after rhTSH stimulation

open access: yesHead and Neck, 2013
Thyroglobulin measurement in the washout of the needle used in fine‐needle aspiration cytology (FNAC) has been proposed for the early detection of lymph node metastasis both in patients with or without serum thyroglobulin antibodies; however, up to now ...
Carlo Cappelli, Maurizio Castellano
exaly   +2 more sources

Canonical TSH Regulation of Cathepsin-Mediated Thyroglobulin Processing in the Thyroid Gland of Male Mice Requires Taar1 Expression

open access: yesFrontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Vladislav Skripnik   +2 more
exaly   +3 more sources

A Mathematical Model of Thyroid Disease Response to Radiotherapy [PDF]

open access: yesMathematics 2021, 9(19), 2365, 2021
We present a mechanistic biomathematical model of molecular radiotherapy of thyroid disease. The general model consists of a set of differential equations describing the dynamics of different populations of thyroid cells with varying degrees of damage caused by radiotherapy (undamaged cells, sub-lethally damaged cells, doomed cells, and dead cells), as
arxiv   +1 more source

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