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The structure of human thyroglobulin [PDF]
Nature, 2020 Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates1,2. Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is completed by TG proteolysis3.
Francesca Coscia +2 more
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The Properties of Thyroglobulin
Journal of Biological Chemistry, 1966 Abstract All the disulfide bonds of thyroglobulin have been completely reduced with β-mercaptoethanol in urea or guanidine at alkaline pH. The molecular properties of reduced carboxymethylated thyroglobulin have been investigated in aqueous solution by sedimentation velocity, viscosity, difference spectra, optical rotation, polarization of fluorescence,
B. de Crombrugghe +2 more
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Frontiers in Pharmacology, 2018 Trace amine-associated receptor 1 (Taar1) has been suggested as putative receptor of thyronamines. These are aminergic messengers with potential metabolic and neurological effects countering their contingent precursors, the thyroid hormones (THs ...
Vladislav Skripnik +2 more
exaly +3 more sources
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen [PDF]
Communications BiologyThyroid hormones are produced by the thyroid gland and are essential for regulating metabolism, growth and development. Maintenance of circulating thyroid hormone levels within an appropriate range is thus a prerequisite for health.
Yihan Yao +9 more
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Subunit Heterogeneity of Thyroglobulin [PDF]
Journal of Biological Chemistry, 1973 The subunit structure of thyroglobulin has been investigated by gel filtration and polyacrylamide electrophoresis in sodium dodecyl sulfate (SDS) of the native and the S-carboxymethylated proteins. When the thyroglobulins from several species (calf, sheep, pig, man, rat, and guinea pig) were examined by polyacrylamide electrophoresis in SDS in the ...
Mary Jane Spiro
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The Carbohydrate Units of Thyroglobulin
Journal of Biological Chemistry, 1965 Robert G. Spiro
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Impact of 18F-FDG PET/CT on treatment of patients with differentiated thyroid carcinoma, negative 131I whole body scan and elevated serum thyroglobulin [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2022 Objective(s): 18F-FDG PET/CT is increasingly performed in patients with differen-tiated thyroid cancer. The aim of this study was to assess the clinical impact of 18F-FDG PET/CT on the management of patients with differentiated thyroid carcinoma who had ...
Raef Boktor +3 more
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Thyroglobulin value in patients surgically treated for differentiated thyroid carcinoma [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2016 Introduction. Thyroglobulin is composed glycoprotein, and it is synthesized by follicular cells of the thyroid gland. Treatment of differentiated thyroid carcinomas involves total thyroidectomy followed by radioiodine ablation of a potential ...
Mikač Gostimir, Stanković Siniša
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Клиническая и экспериментальная тиреоидология, 2017 Iodine deficiency has serious adverse effects on growth and development of humans, such as mental impairment. It is known, that thyroglobulin level in blood is promising biomarker that can determine iodine deficiency disorders severity in a given region.
Saydiganikhodja I. Ismailov +6 more
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The subunits of thyroglobulin [PDF]
Biochemical Journal, 1970 1. Pig thyroglobulin was reduced with dithiothreitol in the presence of sodium dodecyl sulphate, 8m-urea or 6m-guanidinium chloride. 2. The molecular weights of the reduction products were about 165000. 3. Two stable subunits with molecular weights as low as 35000 and 20000 were separated by Sephadex chromatography after prolonged exposure of the ...
P. A. Charlwood +2 more
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