Results 11 to 20 of about 75,403 (287)

Evaluating of significance of thyroglobulin (Tg) level in blood as a biomarker of iodine deficiency disorders severity in Uzbekistan

Клиническая и экспериментальная тиреоидология, 2017
Iodine deficiency has serious adverse effects on growth and development of humans, such as mental impairment. It is known, that thyroglobulin level in blood is promising biomarker that can determine iodine deficiency disorders severity in a given region.
Saydiganikhodja I. Ismailov, Murod M. Rashitov, Nusrat A. Alimdjanov, Kamil K. Uzbekov, Muhammadjon Kh. Vakkasov, Timur F. Muratov, Murodjon N. Omildjonov   +6 more
doaj   +3 more sources

Effect of therapeutic radioiodine activity on ablation response in differentiated thyroid cancer patients with cut-off serum thyroglobulin levels after 2 weeks of thyroid hormone withdrawal: a retrospective study [PDF]

Journal of Medicine and Life Science, 2022
This retrospective study aimed to investigate whether there was a difference in the success rate of removal of residual thyroid tissue in patients with the same cutoff serum thyroglobulin (Tg) value―measured 2 weeks after thyroid hormone withdrawal (THW)―
Ji Young Lee, Hee-Sung Song, Young Hwan Kim   +2 more
doaj   +1 more source

A Novel Mutation in the Thyroglobulin Gene Resulting in Neonatal Goiter and Congenital Hypothyroidism in an Eritrean Infant

JCRPE, 2022
Congenital hypothyroidism (CH) due to dyshormonogenesis may occur due to mutations in any of the key genes involved in thyroid hormone biosynthesis (TG, TPO, DUOX2, DUOXA2, SLC5A5, IYD, SLC26A4 and SLC26A7).
Eve Stern, Nadia Schoenmakers, Adeline K. Nicholas, Eran Kassif, Orit Pinhas Hamiel, Yonatan Yeshayahu   +5 more
doaj   +1 more source

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology. [PDF]

FASEB J
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Young C, Arvan P.
europepmc   +2 more sources

Detecting Recurrence Following Lobectomy for Thyroid Cancer: Role of Thyroglobulin and Thyroglobulin Antibodies.

Journal of Clinical Endocrinology and Metabolism, 2020
BACKGROUND The use of thyroglobuin (Tg) and thyroglobulin antibodies (TgAb) for detecting disease recurrence is well validated following total-thyroidectomy and radioiodine. However, limited data is available for patients treated with thyroid lobectomy.
Amit Ritter, A. Mizrachi, G. Bachar, Igor Vainer, I. Shimon, D. Hirsch, T. Diker-Cohen, Hadar Duskin-Bitan, E. Robenshtok   +8 more
semanticscholar   +1 more source

The structure of human thyroglobulin

Nature, 2020
Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates 1 , 2 .
F. Coscia, Ajda Taler-Verčič, V. Chang, L. Sinn, Francis J. O’Reilly, T. Izoré, M. Renko, I. Berger, J. Rappsilber, D. Turk, J. Löwe   +10 more
semanticscholar   +1 more source

Urinary Exosomal Thyroglobulin in Thyroid Cancer Patients With Post-ablative Therapy: A New Biomarker in Thyroid Cancer

Frontiers in Endocrinology, 2020
Background: Most patients with thyroid cancer typically receive thyroidectomy with ablative radioactive iodine therapy. Such patients were followed with thyroid ultrasonography and serial serum thyroglobulin evaluation. Exosomes are nanovesicles secreted
Tse-Ying Huang, Chih-Yuan Wang, Kuen-Yuan Chen, Li-Ting Huang   +3 more
semanticscholar   +1 more source

Prognostic Value of Serum Thyroglobulin and Anti-Thyroglobulin Antibody in Thyroid Carcinoma Patients following Thyroidectomy

Diagnostics, 2021
Well-differentiated thyroid cancer (WDTC) is a malignant head and neck tumor with a very high incidence. Thyroidectomized WDTC patients have been referred to nuclear medicine for radioactive iodine (RAI) ablation therapy and/or annual follow-up with ...
Hashem O. Zahra, Gamal A. Omran, Ahmed G. Gewely, Ahmed Fathy Eldehn, Walied Abdo, Ehab Kotb Elmahallawy, Tarek M. Okda   +6 more
doaj   +1 more source

The Diagnostic Usefulness of ¹³¹I-SPECT/CT at Both Radioiodine Ablation and during Long-Term Follow-Up in Patients Thyroidectomized for Differentiated Thyroid Carcinoma: Analysis of Tissue Risk Factors Ascertained at Surgery and Correlated with Metastasis Appearance

Diagnostics, 2021
131I Single-photon emission computerized tomography/computerized tomography (SPECT/CT) in the management of patients thyroidectomized for differentiated thyroid carcinoma (DTC) was further investigated.
Angela Spanu, Susanna Nuvoli, Andrea Marongiu, Ilaria Gelo, Luciana Mele, Andrea De Vito, Maria Rondini, Giuseppe Madeddu   +7 more
doaj   +1 more source

Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma [PDF]

, 2009
Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma.
Akagi, Tadaatsu, Kobayashi, Keita, Mannami, Tomohiko, Miyake, Takayoshi, Munemasa, Mitsuru, Sakugawa, Sumie Takase, Shinagawa, Katsuji, Tanimoto, Mitsune, Yoshino, Tadashi   +8 more
core   +1 more source