Results 101 to 110 of about 79,494 (311)

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Contemporary challenges to iodine status and nutrition: the role of foods, dietary recommendations, fortification and supplementation [PDF]

, 2018
Iodine deficiency (ID) in women of childbearing age remains a global public health concern, mainly through its impact on fetal and infant neurodevelopment.
Bouga, M., Combet, E., Lean, M.E.J.
core   +1 more source

How sensitive (second-generation) thyroglobulin measurement is changing paradigms for monitoring patients with differentiated thyroid cancer, in the absence or presence of thyroglobulin autoantibodies

Current Opinion in Endocrinology, Diabetes & Obesity, 2014
Purpose of reviewTo discuss new insights regarding how sensitive (second-generation) thyroglobulin immunometric assays (Tg2GIMAs), (functional sensitivities ⩽0.10 &mgr;g/L) necessitate different approaches for postoperative thyroglobulin monitoring of ...
C. Spencer, J. Lopresti, S. Fatemi
semanticscholar   +1 more source

The spectrum of breast in situ papillary carcinomas with invasion and invasive breast carcinomas with papillary features: an overview of histological subtypes and diagnostic challenges

Histopathology, EarlyView.
Invasive breast carcinomas with papillary features (IBCP) comprise diverse subtypes with variable architecture, histopathology, and clinical behaviour. This review outlines evolving classification, diagnostic criteria, and treatment implications, highlighting challenges in distinguishing in situ from invasive lesions. Standardised diagnostic approaches
Emad A Rakha, Puay Hoon Tan, Wendy A Raymond   +2 more
wiley   +1 more source

Elevated serum thyroglobulin levels as a marker of reversible hypothyroidism in patients with end-stage renal disease due to chronic glomerulonephritis

Cogent Medicine, 2017
Difference in thyroid function depending on the etiology of end-stage renal disease (ESRD) was evaluated in 124 Japanese patients on haemodialysis (HD) due to either chronic glomerulonephritis (CGN, n = 82) or lifestyle related systemic disease (non-CGN,
Toru Sanai, Ken Okamura, Shuichi Rikitake, Tsuyoshi Takashima, Motoaki Miyazono, Yuji Ikeda, Takanari Kitazono   +6 more
doaj   +1 more source

Comparative evaluation of two automated immunoassays for serum thyroglobulin quantification [PDF]

Kosin Medical Journal
Background We evaluated the clinical performance of in vitro diagnostic devices for quantifying thyroglobulin (Tg), which is a key marker for monitoring and treating thyroid dysfunction.
Kyoung Ho Roh, Hyunyong Hwang
doaj   +1 more source

Serum thyroglobulin (Tg) monitoring of patients with differentiated thyroid cancer using sensitive (second-generation) immunometric assays can be disrupted by false-negative and false-positive serum thyroglobulin autoantibody misclassifications.

Journal of Clinical Endocrinology and Metabolism, 2014
CONTEXT Reliable thyroglobulin (Tg) autoantibody (TgAb) detection before Tg testing for differentiated thyroid cancer (DTC) is critical when TgAb status (positive/negative) is used to authenticate sensitive second-generation immunometric assay ((2G)IMA ...
C. Spencer, I. Petrovic, S. Fatemi, J. Lopresti   +3 more
semanticscholar   +1 more source

Systemic Disease Associations of Oral Lichenoid Disease: A Retrospective Case–Control Study

Oral Diseases, EarlyView.
ABSTRACT Objective To analyze the association between oral lichen planus (OLP), oral lichenoid lesions (OLL), and other comorbidities. Material and Methods A case–control study of 205 OLP, 96 OLL patients, and 301 age‐ and sex‐matched controls from Kuopio University Hospital was performed.
Mari Vehviläinen, Tuomas Selander, Tuula Salo, Maria Siponen   +3 more
wiley   +1 more source

Indicadores genómicos y fenotípicos para calidad de la carne en bovinos Charolais de México Indicadores genómicos e fenotípicos na qualidade da carne do gado Charolês no México Genomic and phenotypic beef quality indicators of Charolais cattle in México

Revista Colombiana de Ciencias Pecuarias, 2012
La terneza y el marmoreo son características poligénicas e indicadoras de calidad en la carne bovina. Uno de los genes relacionados con la terneza en la carne es el gen de µ-calpaína (CAPN), en el cual se han identificado dos polimorfismos CAPN316 ...
Carmen Y Muñoz Mejía, Gaspar M Parra Bracamonte, Ana M Sifuentes Rincón, Juan C Martínez González, Luis A López Bustamante, Williams A Vera, Xochitl F de la Rosa Reyna   +6 more
doaj  

Diagnostic role of FNA cytology in the evaluation of cervical lymph nodes in thyroid cancers: Combined evaluation of thyroglobulin in eluate from FNA cytology [PDF]

, 2023
Pietro Tralongo, Carmine Bruno, Federica Policardo, Federica Vegni, Angela Feraco, Angela Carlino, Giulia Ferraro, Domenico Milardi, Elena Navarra, Alfredo Pontecorvi, Celestino Pio Lombardi, Marco Raffaelli, Luigi Maria Larocca, Liron Pantanowitz, Esther Diana Rossi   +14 more
openalex   +1 more source