Results 141 to 150 of about 42,066 (191)
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Thyroglobulin and thyroglobulin autoantibodies: interpret with care
Endocrine, 2013A middle-aged lady with a past history of hyperlipidemia presented to our institution with worsening of a lower back pain that has been present for a year. The back pain radiated down her left lower limb and was associated with left foot numbness and nocturnal pain. On examination, a mass was palpated in the left iliac fossa.
Tze Ping Loh +2 more
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Thyroglobulin-like Antigens in a Goiter with Impaired Thyroglobulin Biosynthesis
The Journal of Clinical Endocrinology & Metabolism, 1974A human congenital goiter has been shown to contain minute amounts of TG-like immunoreactive material (1). The subcellular distribution of the TG-like antigens after differential centrifugation of the homogenate and digitonin solubilization of the particulate fractions has been studied by means of a RIA of TG: 61% of the antigens were found in the ...
Bernal, Juan, Obregón, María Jesús
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Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991
1. Buffalo thyroglobulin is the major iodoprotein of buffalo thyroid with a sedimentation coefficient of 19 S and an apparent molecular mass of 685 kDa. 2. The protein is rich in iodine (1-2%) and thyroxine bound iodine (75%), unlike thyroglobulins of other mammalian species. 3.
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1. Buffalo thyroglobulin is the major iodoprotein of buffalo thyroid with a sedimentation coefficient of 19 S and an apparent molecular mass of 685 kDa. 2. The protein is rich in iodine (1-2%) and thyroxine bound iodine (75%), unlike thyroglobulins of other mammalian species. 3.
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Phosphorylation of 19S Thyroglobulin
1988Thyroglobulin (TG), one of the largest known eukaryotic proteins (Mr 660.000, sedimentation coefficient 19S), plays a central role in thyroid hormonogenesis. TG presents several characteristics of special interest: (i) it represents the major biosynthetic product of thyroid follicular cell1; (ii) under denaturing conditions it can be dissociated into ...
Tassi V. +3 more
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Thyroglobulin and Thyroglobulin Antibodies
2006Thyroglobulin, an approximately 670-kDa glycopeptide, is the major protein product of thyroid follicular cells; its rate of synthesis is increased by thyrotropin (TSH). After synthesis, it is modified by the attachment of iodine to selected tyrosine residues, which undergo rearrangement to form iodothyronines, particularly thyroxine (T4) and, to a ...
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Thyroglobulin and anti-thyroglobulin assays in thyroid cancer monitoring
Clinical Biochemistry, 2009To compare four methods for thyroglobulin (Tg) quantitation and three methods for detection and quantitation of thyroglobulin antibodies (Tg-Ab). We also wanted to explore the premise that thyroglobulin antibodies, as determined by commercially available assays, interfere with thyroglobulin assays in a predictable way.Split sample method comparisons ...
John, Krahn, Tom, Dembinski
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Monoclonal Antibodies to Human Thyroglobulin as Probes for Thyroglobulin Structure*
Endocrinology, 1987A panel of monoclonal antibodies (mAbs) against human thyroglobulin (hTg) was obtained by somatic fusion of the nonsecreting myeloma cell line P3X66 Ag8/0 and spleen cells of Balb/c mice immunized with purified hTg. Antibody secreting clones were selected by solid phase enzyme immunoassay and analyzed for cross-reaction with Tg from several animal ...
M H, De Baets +4 more
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Thyroglobulins of cyclostomes and an elasmobranch
General and Comparative Endocrinology, 1975Abstract As part of a study of the biosynthesis and physicochemical properties of primitive vertebrate thyroglobulins, the thyroid-containing tissues of Pacific hagfish (Eptatretus stouti) and of Pacific lamprey (Entosphenus tridentatus), and thyroid glands of Pacific dogfish (Squalus suckleyi) were used.
S, Suzuki +4 more
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The crystal packing of thyroglobulin
Journal of Molecular Biology, 1968Abstract The molecular packing in 19 s thyroglobulin crystals has been examined using shadowed, positively stained and negatively stained preparations. Crystallizing thyroglobulin molecules first form polymers which are right-handed helices with an average pitch of 228 A having four molecules per turn.
L W, Labaw, J E, Rall
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