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The structure of human thyroglobulin [PDF]

Nature, 2020
Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates1,2. Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is completed by TG proteolysis3.
Francesca Coscia, Ajda Taler-verči, Veronica T Chang   +2 more
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Thyroglobulin and thyroglobulin autoantibodies: interpret with care

Endocrine, 2013
A middle-aged lady with a past history of hyperlipidemia presented to our institution with worsening of a lower back pain that has been present for a year. The back pain radiated down her left lower limb and was associated with left foot numbness and nocturnal pain. On examination, a mass was palpated in the left iliac fossa.
Shih Ling Kao, Tze Ping Loh, Hui Wen Chong   +2 more
openaire   +2 more sources

THE MEASUREMENT OF SERUM THYROGLOBULIN IN THE PRESENCE OF THYROGLOBULIN ANTIBODIES

Clinical Endocrinology, 1981
SUMMARYIn a significant proportion of patients with thyroid disorders, thyroglobulin antibodies (TgAb) invalidate double‐antibody radioimmunoassays (RIA) for thyroglobulin (Tg). A modified RIA procedure for determining serum Tg in the presence of TgAb, is described. Two measurements are made on each sample.
L. A. W. Ayoub, D. Pearson, J. G. Ratcliffe   +2 more
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Thyroglobulin and Thyroglobulin Antibodies

2006
Thyroglobulin, an approximately 670-kDa glycopeptide, is the major protein product of thyroid follicular cells; its rate of synthesis is increased by thyrotropin (TSH). After synthesis, it is modified by the attachment of iodine to selected tyrosine residues, which undergo rearrangement to form iodothyronines, particularly thyroxine (T4) and, to a ...
D. Robert Dufour, D. Robert Dufour, D. Robert Dufour   +2 more
openaire   +2 more sources

Thyroglobulin and Thyroglobulin Antibodies

2018
Differentiated thyroid cancer (DTC) is the most common endocrine cancer, and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131 depending on post-operative risk stratification. As thyroid cells are assumed to be the only source of thyroglobulin (
Renato Tozzoli, Ulla Feldt-Rasmussen, Luca Giovanella, Camilla Schalin-Jäntti, Federica D'Aurizio   +4 more
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Monoclonal Antibodies to Human Thyroglobulin as Probes for Thyroglobulin Structure*

Endocrinology, 1987
A panel of monoclonal antibodies (mAbs) against human thyroglobulin (hTg) was obtained by somatic fusion of the nonsecreting myeloma cell line P3X66 Ag8/0 and spleen cells of Balb/c mice immunized with purified hTg. Antibody secreting clones were selected by solid phase enzyme immunoassay and analyzed for cross-reaction with Tg from several animal ...
Ruud Theunissen, K. Kok, J. J. M. De Vijlder, P. J. C. Van Breda Vriesman, M. De Baets   +4 more
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Phosphorylation of 19S Thyroglobulin

1988
Thyroglobulin (TG), one of the largest known eukaryotic proteins (Mr 660.000, sedimentation coefficient 19S), plays a central role in thyroid hormonogenesis. TG presents several characteristics of special interest: (i) it represents the major biosynthetic product of thyroid follicular cell1; (ii) under denaturing conditions it can be dissociated into ...
Tassi V., Liguoro D., Consiglio E., ACQUAVIVA, ANGELA MARIA   +3 more
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Thyroglobulins of cyclostomes and an elasmobranch

General and Comparative Endocrinology, 1975
Abstract As part of a study of the biosynthesis and physicochemical properties of primitive vertebrate thyroglobulins, the thyroid-containing tissues of Pacific hagfish (Eptatretus stouti) and of Pacific lamprey (Entosphenus tridentatus), and thyroid glands of Pacific dogfish (Squalus suckleyi) were used.
Aubrey Gorbman, Aubrey Gorbman, Marie-France Montfort, Marie-France Montfort, Marcel Rolland, Marcel Rolland, Serge Lissitzky, Serge Lissitzky, Shintaro Suzuki, Shintaro Suzuki   +9 more
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The crystal packing of thyroglobulin

Journal of Molecular Biology, 1968
Abstract The molecular packing in 19 s thyroglobulin crystals has been examined using shadowed, positively stained and negatively stained preparations. Crystallizing thyroglobulin molecules first form polymers which are right-handed helices with an average pitch of 228 A having four molecules per turn.
Louis W. Labaw, J.E. Rall
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Buffalo thyroglobulin

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991
1. Buffalo thyroglobulin is the major iodoprotein of buffalo thyroid with a sedimentation coefficient of 19 S and an apparent molecular mass of 685 kDa. 2. The protein is rich in iodine (1-2%) and thyroxine bound iodine (75%), unlike thyroglobulins of other mammalian species. 3.
openaire   +2 more sources