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CD4+ T cells are essential for the development of destructive thyroiditis induced by anti–PD-1 antibody in thyroglobulin-immunized mice

Science Translational Medicine, 2021
CD4+ T cells are essential for development of thyroiditis induced by anti–PD-1 antibody treatment in thyroglobulin-immunized mice. Adverse events in the thyroid Anti–programmed cell death–1 (PD-1) antibody blockade has revolutionized cancer treatment by ...
Yoshinori Yasuda   +21 more
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Buffalo thyroglobulin

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1991
1. Buffalo thyroglobulin is the major iodoprotein of buffalo thyroid with a sedimentation coefficient of 19 S and an apparent molecular mass of 685 kDa. 2. The protein is rich in iodine (1-2%) and thyroxine bound iodine (75%), unlike thyroglobulins of other mammalian species. 3.
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Thyroglobulin and Thyroglobulin Antibodies

2018
Differentiated thyroid cancer (DTC) is the most common endocrine cancer, and its incidence has increased in recent decades. Initial treatment usually consists of total thyroidectomy followed by ablation of thyroid remnants by iodine-131 depending on post-operative risk stratification. As thyroid cells are assumed to be the only source of thyroglobulin (
Luca Giovanella   +4 more
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Thyroglobulin and thyroglobulin autoantibodies: interpret with care

Endocrine, 2013
A middle-aged lady with a past history of hyperlipidemia presented to our institution with worsening of a lower back pain that has been present for a year. The back pain radiated down her left lower limb and was associated with left foot numbness and nocturnal pain. On examination, a mass was palpated in the left iliac fossa.
Tze Ping Loh   +2 more
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Thyroglobulin and Thyroglobulin Antibodies

2006
Thyroglobulin, an approximately 670-kDa glycopeptide, is the major protein product of thyroid follicular cells; its rate of synthesis is increased by thyrotropin (TSH). After synthesis, it is modified by the attachment of iodine to selected tyrosine residues, which undergo rearrangement to form iodothyronines, particularly thyroxine (T4) and, to a ...
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