Results 341 to 350 of about 395,029 (382)
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Physiological Reviews, 2002
This review focuses on recent advances in the structure-function relationships of thyroid-stimulating hormone (TSH) and its receptor. TSH is a member of the glycoprotein hormone family constituting a subset of the cystine-knot growth factor superfamily.
Bruce D. Weintraub +3 more
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This review focuses on recent advances in the structure-function relationships of thyroid-stimulating hormone (TSH) and its receptor. TSH is a member of the glycoprotein hormone family constituting a subset of the cystine-knot growth factor superfamily.
Bruce D. Weintraub +3 more
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Endocrinology and Metabolism Clinics of North America, 2009
The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and is also one of the major autoantigens for the autoimmune thyroid diseases. We review the post-translational processing, multimerization, and intramolecular cleavage of TSHR, all of which may modulate its signal transduction.
Terry F. Davies +3 more
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The thyroid-stimulating hormone receptor (TSHR) has a central role in thyrocyte function and is also one of the major autoantigens for the autoimmune thyroid diseases. We review the post-translational processing, multimerization, and intramolecular cleavage of TSHR, all of which may modulate its signal transduction.
Terry F. Davies +3 more
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Artifactual elevation of thyroid-stimulating hormone
The American Journal of Medicine, 1991A clinically euthyroid patient was found to have a normal serum thyroxine level and an elevated plasma thyrotropin (TSH) level measured by fluoroimmunoassay. Thyroid hormone therapy failed to suppress the TSH level. The TSH level was unresponsive to thyrotropin-releasing hormone (TRH) administration, alpha-subunits of pituitary glycoproteins were ...
Marion M. Brooks +3 more
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Journal of Endocrinology, 1984
ABSTRACT Previous studies have shown that freezing and thawing of human thyroid homogenates releases a water-soluble substance which reversibly binds to TSH-receptor antibodies. This substance has been designated long-acting thyroid stimulator absorbing activity (LAA).
B. Rees Smith, E. Davies Jones
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ABSTRACT Previous studies have shown that freezing and thawing of human thyroid homogenates releases a water-soluble substance which reversibly binds to TSH-receptor antibodies. This substance has been designated long-acting thyroid stimulator absorbing activity (LAA).
B. Rees Smith, E. Davies Jones
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Pituitary thyroid-stimulating hormone and thyroid-stimulating immunoglobulins
1976Thyroid function can be stimulated by several macromolecules, including pituitary thyroid-stimulating hormone (TSH), human chorionic thyrotrophin (HCT), human molar thyrotophin (HMT) and a population of thyroid-stimulating immunoglobulins. This paper attempts to review concisely the properties of these thyroid stimulators.
B. R. Smith, R. Hall
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A MODIFIED BIOASSAY FOR THYROID-STIMULATING HORMONE AND LONG-ACTING THYROID STIMULATOR [PDF]
Journal of Endocrinology, 1974 SUMMARY After iodine depletion of mice, the time needed for the bioassay of long-acting thyroid stimulator (LATS) and thyroid-stimulating hormone (TSH) can be shortened to allow the completion of two assays per week. Suppression of mouse TSH with 0·1 μg tri-iodothyronine was necessary in the TSH assay and with 5 μg thyroxine in the LATS assay ...
J. Nutt, F. Clark, K. Humphreys
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1994
A glycopeptide (M.Wt. 32 kDa) containing approximately 16% carbohydrate, secreted by the thyrotrophs of the anterior pituitary.
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A glycopeptide (M.Wt. 32 kDa) containing approximately 16% carbohydrate, secreted by the thyrotrophs of the anterior pituitary.
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Interference in thyroid‐stimulating hormone determination
European Journal of Clinical Investigation, 2010Eur J Clin Invest 2010; 40 (8): 756–758AbstractBackground Thyroid‐stimulating hormone (TSH) measurement plays a major role in the diagnosis of thyroid disorders. Despite the good quality of immunochemical tests measuring TSH levels, the presence of interfering substances can sometimes alter the TSH results.Design We reported the case of a 79‐year‐old
Luca Giovanella +6 more
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Crystallization of Bovine Thyroid Stimulating Hormone
Endocrinology, 1967Bovine thyroid stimulating hormone was extracted with ammonium sulfate solutions of decreasing concentrations. Crystals of the hormone separated upon storage of the extracts at room temperature. (Endocrinology 80: 203, 1967)
William B. Jakoby, Peter G. Condliffe
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Thyroid-stimulating hormone pituitary adenomas
Journal of Neurosurgery, 2008Object Thyroid-stimulating hormone (TSH)–secreting pituitary adenomas are rare, representing < 2% of all pituitary adenomas. Methods The authors conducted a retrospective analysis of patients with TSH-secreting or clinically silent TSH-immunostaining pituitary tumors among all pituitary adenomas followed at their institution between 1987 and 2003.
John L.D. Atkinson +3 more
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