Results 51 to 60 of about 14,074 (215)

Thyroid Function and Anti-thyroid Antibodies in Pediatric Anti-NMDAR Encephalitis

Frontiers in Neurology, 2021
Objective: Recent studies found that changes of thyroid antibodies (ATAbs), thyroid hormone, and non-thyroidal illness syndrome (NTIS) characterized by thyroid hormone inactivation with low triiodothyronine and high reverse triiodothyronine followed by ...
Lianfeng Chen, Wenlin Wu, Yang Tian, Yiru Zeng, Chi Hou, Haixia Zhu, Kelu Zheng, Yani Zhang, Yuanyuan Gao, Bingwei Peng, Sida Yang, Xiuying Wang, Shuyao Ning, Yinting Liao, Haisheng Lin, Kaili Shi, Xiaojing Li, Wen-Xiong Chen   +17 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Tissue-Specific Posttranslational Modification Allows Functional Targeting of Thyrotropin

Cell Reports, 2014
Thyroid-stimulating hormone (TSH; thyrotropin) is a glycoprotein secreted from the pituitary gland. Pars distalis-derived TSH (PD-TSH) stimulates the thyroid gland to produce thyroid hormones (THs), whereas pars tuberalis-derived TSH (PT-TSH) acts on the
Keisuke Ikegami, Xiao-Hui Liao, Yuta Hoshino, Hiroko Ono, Wataru Ota, Yuka Ito, Taeko Nishiwaki-Ohkawa, Chihiro Sato, Ken Kitajima, Masayuki Iigo, Yasufumi Shigeyoshi, Masanobu Yamada, Yoshiharu Murata, Samuel Refetoff, Takashi Yoshimura   +14 more
doaj   +1 more source

Detection of macro-thyrotropinaemia in patients with Hashimotos thyroiditis and subclinical hypothyroidism

Медицинская иммунология, 2020
The level of thyroid stimulating hormone is one of the diagnostic indicators of thyroid function. In subclinical hypothyroidism, its concentration in the blood serum increases, while the level of thyroid hormones remains normal.
E. M. Biktagirova, G. R. Vagapova, G. P. Semakov, N. I. Zolotoverkchova, T. A. Nevzorova, I. A. Andrianova, N. G. Evtyugina, N. I. Akberova, A. N. Khisamutdinov, Z. I. Abramova   +9 more
doaj   +1 more source

The Relationship of Thyroid Nodules with Total Serum IgE Level and Metabolic Parameters in Patients with Hashimoto Thyroiditis

İstanbul Medical Journal, 2021
Introduction:The literature demonstrates elevated immunoglobulin E (IgE) levels in autoimmune thyroid diseases and their relationship with allergic diseases.
İdris Kalkan, Hanife Usta Atmaca, Feray Akbaş   +2 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Hyperthyroidism from autoimmune thyroiditis in a man with type 1 diabetes mellitus: a case report

Journal of Medical Case Reports, 2011
Introduction The presentation, diagnosis, clinical course and treatment of a man with hyperthyroidism secondary to autoimmune thyroiditis in the setting of type 1 diabetes mellitus has not previously been described.
Hirsch Irl B, Amory John K
doaj   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Slow evolution of non-familial autoimmune polyglandular syndrome type II in a 54-year-old female, first presenting with Addison’s disease, then Hashimoto’s thyroiditis, which then transitioned to Graves’ disease and then the development of type 1 diabetes

European Journal of Case Reports in Internal Medicine
Background: Autoimmune polyglandular syndrome type II (APS-II) is a rare disorder defined by primary adrenal insufficiency in combination with autoimmune thyroid disease and/or type 1 diabetes mellitus.
Ghayda’ E’leimat, Thuy Hao Nguyen, Hemant Thawani   +2 more
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source