Results 31 to 40 of about 513,992 (266)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Postpartum thyroid function following LT4 treatment from infertility treatment to delivery in women with subclinical hypothyroidism or high-normal TSH: a retrospective study

BMC Endocrine Disorders
Background Levothyroxine (LT4) therapy is commonly initiated in women undergoing infertility treatment who have high-normal thyroid-stimulating hormone (TSH) levels (HN) or subclinical hypothyroidism (SCH).
Yuka Tsukamoto, Yoh Hidaka, Yoshiko Fukuda, Yuko Wada, Kazuyo Okamoto, Yasuyuki Okamoto   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Perioperative endocrine dynamics in euthyroid versus hyperthyroid patients with Graves’ disease undergoing total thyroidectomy: a prospective cohort study

BMC Surgery
Background Total thyroidectomy is a definitive treatment for Graves’ disease, but perioperative endocrine dynamics may differ depending on preoperative thyroid function.
Hiroyuki Yamashita, Kouichi Yoshimoto, Misa Okamura, Hisakazu Shindo, Yusuke Mori, Kento Katsuyama, Daisuke Tatsushima, Seigo Tachibana, Takashi Fukuda, Atushi Yamaoka, Hiroshi Takahashi, Yuji Nagayama, Shinya Sato   +12 more
doaj   +1 more source

THYROIDISM [PDF]

The American Journal of the Medical Sciences, 1896
n ...
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Trends in influenza and pneumococcal vaccine coverage in Thai patients with type 2 diabetes mellitus 2010–2018: Experience from a tertiary diabetes center in Bangkok

Journal of Clinical & Translational Endocrinology, 2020
Trends in influenza and pneumococcal vaccine coverage in Thai patients with type 2 diabetes mellitus 2010–2018: Experience from a tertiary diabetes center in Bangkok. Background: Routine vaccination is an important part of preventive services in treating
Yotsapon Thewjitcharoen, Siriwan Butadej, Areeya Malidaeng, Nalin Yenseung, Soontaree Nakasatien, Nampetch Lekpittaya, Worawit Kittipoom, Sirinate Krittiyawong, Thep Himathongkam   +8 more
doaj   +1 more source

Thyroid Hemiagenesis Associated with Hashimoto’s Thyroiditis [PDF]

Case Reports in Endocrinology, 2013
Thyroid hemiagenesis is a rare congenital anomaly resulting from failure of one thyroid lobe development. We report a 23-year-old female presented with Hashimoto’s thyroiditis in left lobe, associated with hemiagenesis of right lobe and isthmus which was previously diagnosed as Graves’ hyperthyroidism, but developed further into Hashimoto’s thyroiditis
D. Nsame, A. Chadli, L. Hallab, S. El Aziz, H. El Ghomari, A. Farouqi   +5 more
openaire   +3 more sources