Results 151 to 160 of about 74,876 (285)
Acta Clinica Croatica, 2011 The aim of the study was to determine epidemiological characteristics of thyroid cancer in Dalmatia and Slavonia, to analyze regional differences in its incidence, and to determine whether iodine intake had an impact on the incidence.
Nikola Kolja Poljak +5 more
doaj
Veterinary Radiology &Ultrasound, Volume 67, Issue 4, July 2026.ABSTRACT This report describes a 25‐year‐old, intact male brown bear (Ursus arctos) presenting with weight loss, diarrhea, melena, apathy, and a 12% hematocrit. Ultrasound showed proximal duodenal wall thickening with submucosal cysts and a large, heterogeneous, highly vascularized mass in the descending duodenum, containing small gas pockets and ...
Mariana Giendruczak de Souza +8 more
wiley +1 more source
Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou +10 more
wiley +1 more source
Rare association of papillary carcinoma of thyroid with adult T-cell lymphoma/leukemia
Indian Journal of Pathology and Microbiology, 2010 Papillary carcinoma is the most common malignant tumor of the thyroid, especially in countries with adequate or excess iodine in diet. Many studies indicate that a sizable number of papillary cancer cases occur in a setting of chronic thyroiditis.
Khadilkar Urmila +3 more
doaj
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, Volume 13, Issue 35, 24 June 2026.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Cancer Innovation, Volume 5, Issue 3, June 2026.This study demonstrates multiple primary malignancies (MPMs) occur in 4.01% of gastric cancer patients and most commonly involve the esophagus, colorectum, and lung. Distinct differences are observed between synchronous and metachronous cases. These findings establish a clinical and epidemiological framework to inform future investigations into MPMs in
Guiling Zhu +6 more
wiley +1 more source
The receptor tyrosine kinase RET is a Hsp90 client protein and is degraded upon exposure to 17-AAG.
, 2009 Molecular alterations of the receptor tyrosin kinase RET are involved in the pathogenesis of thyroid cancer. Germline point mutations in the extracellular and intracellular domains of the receptor are responsible of a group of inherited cancer diseases ...
Alfano, Luigi
core
TTK Overexpression: A Negative Prognostic Biomarker in Anaplastic Thyroid Carcinoma
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Given threonine and tyrosine kinase (TTK)'s oncogenic role in various cancers and its understudied status in thyroid cancer, this study investigates TTK expression in thyroid lesions to assess its diagnostic and therapeutic potential. Methods We analyzed differential TTK expression levels using public datasets (n = 143) and clinical
Yan Guo +7 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background The individual prognostic impacts of BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma (PTC) are established, but the clinical significance of their co‐occurrence, especially when assessed preoperatively, requires further elucidation.
Chang Deng +4 more
wiley +1 more source